Detailed Cardiac - Systemic Venous Sinus - Revision history

Z8600021 at 08:00, 16 April 2018

2018-04-16T08:00:10Z

← Older revision		Revision as of 19:00, 16 April 2018
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	In the [[Chicken Development\|chicken model]], this region develops at the junction between the splanchnic and somatic mesoderm.~~<ref name=~~PMID21779373~~><pubmed>21779373</pubmed> [http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022055 PLoS One]</ref>~~		In the [[Chicken Development\|chicken model]], this region develops at the junction between the splanchnic and somatic mesoderm.{{#pmid:21779373\|PMID21779373}}

	==Some Recent Findings==		==Some Recent Findings==
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	* '''Development of the pulmonary vein and the systemic venous sinus: an interactive 3D overview'''~~<ref name=~~PMID21779373~~><pubmed>21779373</pubmed> [http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022055 PLoS One]</ref>~~ "we present a 3D study of the developing venous pole in the chicken embryo, showing our results in a novel interactive fashion, which permits the reader to form an independent opinion. We clarify how the pulmonary vein separates from a greater vascular plexus within the splanchnic mesoderm. The systemic venous sinus, in contrast, develops at the junction between the splanchnic and somatic mesoderm."		* '''Development of the pulmonary vein and the systemic venous sinus: an interactive 3D overview'''{{#pmid:21779373\|PMID21779373}} "we present a 3D study of the developing venous pole in the chicken embryo, showing our results in a novel interactive fashion, which permits the reader to form an independent opinion. We clarify how the pulmonary vein separates from a greater vascular plexus within the splanchnic mesoderm. The systemic venous sinus, in contrast, develops at the junction between the splanchnic and somatic mesoderm."

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Z8600021: /* Expansion of the Atrioventricular Canal */

2017-03-09T03:34:00Z

Expansion of the Atrioventricular Canal

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	The heart with tricuspid atresia, like double inlet left ventricle, is also functionally univentricular. Other variants of hearts with double inlet and absent atrioventricular connection can have the right ventricle as the dominant ventricular chamber, implying excessive expansion of the atrioventricular canal, and hence later timing of the process disturbing normal morphological development. The lesions illustrated with the atrioventricular junctions, representing the remnants of the embryonic atrioventricular canal, connecting only with the morphologically left ventricle, nonetheless, serve to show the importance of appreciating the timing of the various events occurring during cardiac development. In the settings with univentricular connection to the dominant left ventricle, the insult must have occurred within the initial five weeks of human development. On very rare occasions, it is also possible to find double inlet to a truly solitary ventricle. This implies failure of ballooning of the apical ventricular components, with the insult presumably occurring even earlier than the one producing double inlet left ventricle.		The heart with tricuspid atresia, like double inlet left ventricle, is also functionally univentricular. Other variants of hearts with double inlet and absent atrioventricular connection can have the right ventricle as the dominant ventricular chamber, implying excessive expansion of the atrioventricular canal, and hence later timing of the process disturbing normal morphological development. The lesions illustrated with the atrioventricular junctions, representing the remnants of the embryonic atrioventricular canal, connecting only with the morphologically left ventricle, nonetheless, serve to show the importance of appreciating the timing of the various events occurring during cardiac development. In the settings with univentricular connection to the dominant left ventricle, the insult must have occurred within the initial five weeks of human development. On very rare occasions, it is also possible to find double inlet to a truly solitary ventricle. This implies failure of ballooning of the apical ventricular components, with the insult presumably occurring even earlier than the one producing double inlet left ventricle.

	~~==Expansion of the Atrioventricular Canal==~~
	As indicated above, the next crucial event in cardiac development is rightward expansion of the atrioventricular canal. It was rightward shift of the systemic venous tributaries that brought all the blood from the developing embryo back to the right half of the common atrial chamber. The rightward expansion of the atrioventricular canal, occurring during the latter half of the [[Week 5\|fifth week]] of development in the human, and early on [[:Category:Mouse E11.5\|E11.5]] in the mouse, now brings the cavity of the right atrium into direct continuity with the right ventricle, and thus produces the right ventricular inlet component (Figure 12).

	~~<div id="Fig12"></div>~~
	~~[[File:Anderson2016-fig12a.jpg\|400px]][[File:Anderson2016-fig12b.jpg\|400px]]~~

	'''Fig. 12.''' The left hand image is from an episcopic dataset prepared from a developing mouse embryo early on [[:Category:Mouse E11.5\|E11.5]]. The section is taken in so-called “four chamber” plane. The atrioventricular canal has expanded rightward so that the right atrium is now in direct continuity (white arrow) with the developing right ventricle (RV). There has also been growth of the primary atrial septum, with the primary foramen now seen between its leading edge, which is capped by mesenchyme, and the cranial margin of the inferior atrioventricular (AV) cushions. Note that there is also a space between the caudal edge of the cushion and the crest of the muscular ventricular septum. This is the reorientated embryonic interventricular foramen. The right hand panel is a histological section, again taken in the so-called “four chamber plane”, from a human embryo at [[Carnegie stage 16\|Carnegie stage 16]], representing the end of the fifth week of development. As can be seen, it is directly comparable with the situation as shown in the mouse heart. The section in the human heart is taken between the atrioventricular cushions, which have yet to fuse at this stage of development. This shows that there is a large defect, well described as an atrioventricular septal defect, through which all four cardiac chambers are in free communication.

	==References==		==References==

Z8600021 at 03:32, 9 March 2017

2017-03-09T03:32:12Z

← Older revision		Revision as of 14:32, 9 March 2017
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	==Remodelling of the Venous Tributaries==		==Remodelling of the Venous Tributaries==
			[[File:Robert Anderson.jpg\|thumb\|150px\|alt=Robert Anderson\|Robert H. Anderson]]
	By [[Contributors#Prof_Robert_Anderson\|Robert H. Anderson]]		By [[Contributors#Prof_Robert_Anderson\|Robert H. Anderson]]

Z8600021: /* Formation and Subsequent Remodelling of the Tributaries of the Systemic Venous Sinus */

2017-02-18T19:25:32Z

Formation and Subsequent Remodelling of the Tributaries of the Systemic Venous Sinus

← Older revision		Revision as of 06:25, 19 February 2017
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	=Formation and Subsequent Remodelling of the Tributaries of the Systemic Venous Sinus=		=Formation and Subsequent Remodelling of the Tributaries of the Systemic Venous Sinus=

	The systemic venous sinus is also called the "sinus venosus"~~. A~~ thin walled cavity, forming the input to developing heart which has 3 venous inputs (vitelline vein, umbilical vein, common cardinal vein). Later in heart development this structure gets incorporated into the wall of the future right atrium. The sinuatrial orifice, is the opening between the sinus venosus and right atrium which has two valve leaflets to prevent backflow of blood. The sinus venarum, is the smooth-walled portion of the adult right atrium; originally the left horn of the sinus venous.		The systemic venous sinus, also called the "sinus venosus", is a thin walled cavity forming the input to developing heart which has 3 venous inputs (vitelline vein, umbilical vein, common cardinal vein). Later in heart development this structure gets incorporated into the wall of the future right atrium. The sinuatrial orifice, is the opening between the sinus venosus and right atrium which has two valve leaflets to prevent backflow of blood. The sinus venarum, is the smooth-walled portion of the adult right atrium; originally the left horn of the sinus venous.

Z8600021 at 19:16, 18 February 2017

2017-02-18T19:16:51Z

← Older revision		Revision as of 06:16, 19 February 2017
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	=Formation and Subsequent Remodelling of the Tributaries of the Systemic Venous Sinus=		=Formation and Subsequent Remodelling of the Tributaries of the Systemic Venous Sinus=

	The systemic venous sinus is also called the "sinus venosus". A thin walled cavity, forming the input to developing heart which has 3 venous inputs (vitelline vein, umbilical vein, common cardinal vein). Later in heart development this structure gets incorporated into the wall of the future right atrium.		The systemic venous sinus is also called the "sinus venosus". A thin walled cavity, forming the input to developing heart which has 3 venous inputs (vitelline vein, umbilical vein, common cardinal vein). Later in heart development this structure gets incorporated into the wall of the future right atrium. The sinuatrial orifice, is the opening between the sinus venosus and right atrium which has two valve leaflets to prevent backflow of blood. The sinus venarum, is the smooth-walled portion of the adult right atrium; originally the left horn of the sinus venous.

Z8600021 at 19:15, 18 February 2017

2017-02-18T19:15:05Z

← Older revision		Revision as of 06:15, 19 February 2017
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	Search: [https://www.ncbi.nlm.nih.gov/pubmed/?term=Anderson%20RH%5BAuthor%5D&cauthor=true&cauthor_uid=28011797 PubMed - Anderson RH]		Search: [https://www.ncbi.nlm.nih.gov/pubmed/?term=Anderson%20RH%5BAuthor%5D&cauthor=true&cauthor_uid=28011797 PubMed - Anderson RH]
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	{{Detailed Heart Links}}		{{Detailed Heart Links}}
	=Formation and Subsequent Remodelling of the Tributaries of the Systemic Venous Sinus=		=Formation and Subsequent Remodelling of the Tributaries of the Systemic Venous Sinus=

	The systemic venous sinus is also called the "sinus venosus". In the [[Chicken Development\|chicken model]] this region develops at the junction between the splanchnic and somatic mesoderm.<ref name=PMID21779373><pubmed>21779373</pubmed> [http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022055 PLoS One]</ref>		The systemic venous sinus is also called the "sinus venosus". A thin walled cavity, forming the input to developing heart which has 3 venous inputs (vitelline vein, umbilical vein, common cardinal vein). Later in heart development this structure gets incorporated into the wall of the future right atrium.


			In the [[Chicken Development\|chicken model]], this region develops at the junction between the splanchnic and somatic mesoderm.<ref name=PMID21779373><pubmed>21779373</pubmed> [http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022055 PLoS One]</ref>

	==Some Recent Findings==		==Some Recent Findings==

Z8600021 at 19:13, 18 February 2017

2017-02-18T19:13:01Z

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	=Formation and Subsequent Remodelling of the Tributaries of the Systemic Venous Sinus=		=Formation and Subsequent Remodelling of the Tributaries of the Systemic Venous Sinus=

			The systemic venous sinus is also called the "sinus venosus". In the [[Chicken Development\|chicken model]] this region develops at the junction between the splanchnic and somatic mesoderm.<ref name=PMID21779373><pubmed>21779373</pubmed> [http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022055 PLoS One]</ref>

	==Some Recent Findings==		==Some Recent Findings==
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	* <ref name=~~PMID~~><pubmed></pubmed></ref>		* '''Development of the pulmonary vein and the systemic venous sinus: an interactive 3D overview'''<ref name=PMID21779373><pubmed>21779373</pubmed> [http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022055 PLoS One]</ref> "we present a 3D study of the developing venous pole in the chicken embryo, showing our results in a novel interactive fashion, which permits the reader to form an independent opinion. We clarify how the pulmonary vein separates from a greater vascular plexus within the splanchnic mesoderm. The systemic venous sinus, in contrast, develops at the junction between the splanchnic and somatic mesoderm."

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	{\| class="wikitable mw-collapsible mw-collapsed"		{\| class="wikitable mw-collapsible mw-collapsed"
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	==Remodelling of the Venous Tributaries==		==Remodelling of the Venous Tributaries==

Z8600021 at 18:59, 18 February 2017

2017-02-18T18:59:52Z

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	<pubmed limit=5>Systemic Venous Sinus Development</pubmed>		<pubmed limit=5>Systemic Venous Sinus Development</pubmed>


			Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Coronary+Sinus+Development ''Coronary Sinus Development'']

			<pubmed limit=5>Coronary Sinus Development</pubmed>

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Z8600021 at 18:55, 18 February 2017

2017-02-18T18:55:31Z

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	{{Detailed Heart Links}}		{{Detailed Heart Links}}
	=Formation and Subsequent Remodelling of the Tributaries of the Systemic Venous Sinus=		=Formation and Subsequent Remodelling of the Tributaries of the Systemic Venous Sinus=

	~~By [[Contributors#Prof_Robert_Anderson\|Robert H. Anderson]]~~


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	<pubmed limit=5>Systemic Venous Sinus Development</pubmed>		<pubmed limit=5>Systemic Venous Sinus Development</pubmed>
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	==Remodelling of the Venous Tributaries==		==Remodelling of the Venous Tributaries==
			By [[Contributors#Prof_Robert_Anderson\|Robert H. Anderson]]

	Further development of the atrial chambers, which occurs concomitant with the process of ballooning, requires remodeling of the venous channels which bring the blood back to the heart. There are three such sets of venous tributaries.They bring blood from the embryo, the yolk sac, and the placenta, respectively. The three sets unify to form the so-called sinus horns, which then drain to the initial atrial part of the heart tube. At the initial stages, when the blood enters the atrial component of the heart on each side through the so-called sinus horns, there is minimal formation of the lungs, so there are no pulmonary veins. It is the systemic venous return, therefore, which enters both sides of the atrial part of the tube. This part of the tube, moreover, remains connected to the body of the embryo through a stalk, known as the dorsal mesocardium. The dorsal mesocardium is bordered by two prominences known as the pulmonary ridges. The connection with the pharyngeal mesenchyme through the heart stalk will eventually, subsequent to the development of vascular channels within the lung buds, function as the portal of entry for the pulmonary vein (Figure 4).		Further development of the atrial chambers, which occurs concomitant with the process of ballooning, requires remodeling of the venous channels which bring the blood back to the heart. There are three such sets of venous tributaries.They bring blood from the embryo, the yolk sac, and the placenta, respectively. The three sets unify to form the so-called sinus horns, which then drain to the initial atrial part of the heart tube. At the initial stages, when the blood enters the atrial component of the heart on each side through the so-called sinus horns, there is minimal formation of the lungs, so there are no pulmonary veins. It is the systemic venous return, therefore, which enters both sides of the atrial part of the tube. This part of the tube, moreover, remains connected to the body of the embryo through a stalk, known as the dorsal mesocardium. The dorsal mesocardium is bordered by two prominences known as the pulmonary ridges. The connection with the pharyngeal mesenchyme through the heart stalk will eventually, subsequent to the development of vascular channels within the lung buds, function as the portal of entry for the pulmonary vein (Figure 4).

Z8600021 at 18:55, 18 February 2017

2017-02-18T18:55:04Z

← Older revision		Revision as of 05:55, 19 February 2017
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	By [[Contributors#Prof_Robert_Anderson\|Robert H. Anderson]]		By [[Contributors#Prof_Robert_Anderson\|Robert H. Anderson]]


			==Some Recent Findings==
			{\|
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			* <ref name=PMID><pubmed></pubmed></ref>
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			{\| class="wikitable mw-collapsible mw-collapsed"
			! More recent papers
			\|-
			\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}

			Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Systemic+Venous+Sinus+Development ''Systemic Venous Sinus Development'']

			<pubmed limit=5>Systemic Venous Sinus Development</pubmed>
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	==Remodelling of the Venous Tributaries==		==Remodelling of the Venous Tributaries==