Abnormal Development - Lassa Virus - Revision history

Z8600021 at 03:40, 8 September 2015

2015-09-08T03:40:06Z

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	<div style="background:#F5FFFA; border: 1px solid #CEF2E0; padding: 1em; margin: auto; width: 95%; float:left;"><div style="margin:0;background-color:#cef2e0;font-family:sans-serif;font-size:120%;font-weight:bold;border:1px solid #a3bfb1;text-align:left;color:#000;padding-left:0.4em;padding-top:0.2em;padding-bottom:0.2em;">Notice - Mark Hill</div>Currently this page is only a template and will be updated (this notice removed when completed).</div>		{{Header}}

	==Introduction==		==Introduction==
	[[File:Lassa_virus.jpg\|thumb\|Lassa virus]]		[[File:Lassa_virus.jpg\|thumb\|Lassa virus]]

S8600021: /* References */

2011-11-04T00:55:51Z

References

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 * '''Lassa hemorrhagic fever in a late term pregnancy from northern Sierra Leone with a positive maternal outcome: case report'''<ref><pubmed>21843352</pubmed></ref> "Herein we present the first comprehensive rapid diagnosis and real time characterization of an acute hemorrhagic LF case at KGH LFW. This case report focuses on a third trimester pregnant Sierra Leonean woman from the historically non-endemic Northern district of Tonkolili who survived the illness despite fetal demise. Employed in this study were newly developed recombinant LASV Antigen Rapid Test cassettes and dipstick lateral flow immunoassays (LFI) that enabled the diagnosis of LF within twenty minutes of sample collection. Deregulation of overall homeostasis, significant hepatic and renal system involvement, and immunity profiles were extensively characterized during the course of hospitalization. Rapid diagnosis, prompt treatment with a full course of intravenous (IV) ribavirin, IV fluids management, and real time monitoring of clinical parameters resulted in a positive maternal outcome despite admission to the LFW seven days post onset of symptoms, fetal demise, and a natural still birth delivery."
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 ==References==

S8600021: /* Some Recent Findings */

2011-11-04T00:43:50Z

Some Recent Findings

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	* '''Emerging trends in Lassa Fever: redefining the role of immunoglobulin M and inflammation in diagnosing acute infection'''<ref><pubmed>22023795</pubmed></ref> "Only Lassa virus (LASV) viremia assessed by Ag-capture immunoassay, nucleic acid detection or virus isolation should be used to diagnose acute LASV infection in West Africans. LASV-specific IgM serostatus cannot be considered a diagnostic marker of acute Lassa fever (LF) in suspected cases living in endemic areas of West Africa. By applying these criteria, we identified a dysregulated metabolic and pro-inflammatory response profile conferring a poor prognosis in acute LF. In addition to suggesting that the current diagnostic paradigm for acute LF should be reconsidered, these studies present new opportunities for therapeutic interventions based on potential prognostic markers in LF."		* '''Emerging trends in Lassa Fever: redefining the role of immunoglobulin M and inflammation in diagnosing acute infection'''<ref><pubmed>22023795</pubmed></ref> "Only Lassa virus (LASV) viremia assessed by Ag-capture immunoassay, nucleic acid detection or virus isolation should be used to diagnose acute LASV infection in West Africans. LASV-specific IgM serostatus cannot be considered a diagnostic marker of acute Lassa fever (LF) in suspected cases living in endemic areas of West Africa. By applying these criteria, we identified a dysregulated metabolic and pro-inflammatory response profile conferring a poor prognosis in acute LF. In addition to suggesting that the current diagnostic paradigm for acute LF should be reconsidered, these studies present new opportunities for therapeutic interventions based on potential prognostic markers in LF."
			* '''Lassa hemorrhagic fever in a late term pregnancy from northern Sierra Leone with a positive maternal outcome: case report'''<ref><pubmed>21843352</pubmed></ref> "Herein we present the first comprehensive rapid diagnosis and real time characterization of an acute hemorrhagic LF case at KGH LFW. This case report focuses on a third trimester pregnant Sierra Leonean woman from the historically non-endemic Northern district of Tonkolili who survived the illness despite fetal demise. Employed in this study were newly developed recombinant LASV Antigen Rapid Test cassettes and dipstick lateral flow immunoassays (LFI) that enabled the diagnosis of LF within twenty minutes of sample collection. Deregulation of overall homeostasis, significant hepatic and renal system involvement, and immunity profiles were extensively characterized during the course of hospitalization. Rapid diagnosis, prompt treatment with a full course of intravenous (IV) ribavirin, IV fluids management, and real time monitoring of clinical parameters resulted in a positive maternal outcome despite admission to the LFW seven days post onset of symptoms, fetal demise, and a natural still birth delivery."
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S8600021: /* Some Recent Findings */

2011-11-04T00:40:33Z

Some Recent Findings

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			* '''Emerging trends in Lassa Fever: redefining the role of immunoglobulin M and inflammation in diagnosing acute infection'''<ref><pubmed>22023795</pubmed></ref> "Only Lassa virus (LASV) viremia assessed by Ag-capture immunoassay, nucleic acid detection or virus isolation should be used to diagnose acute LASV infection in West Africans. LASV-specific IgM serostatus cannot be considered a diagnostic marker of acute Lassa fever (LF) in suspected cases living in endemic areas of West Africa. By applying these criteria, we identified a dysregulated metabolic and pro-inflammatory response profile conferring a poor prognosis in acute LF. In addition to suggesting that the current diagnostic paradigm for acute LF should be reconsidered, these studies present new opportunities for therapeutic interventions based on potential prognostic markers in LF."
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S8600021: /* Some Recent Findings */

2011-11-04T00:37:25Z

Some Recent Findings

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	==References==		==References==

S8600021 at 00:36, 4 November 2011

2011-11-04T00:36:20Z

← Older revision		Revision as of 10:36, 4 November 2011
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	==Introduction==		==Introduction==
	Lassa virus is a member of the virus family Arenaviridae, a single-stranded RNA virus. The virus is the causative agent of a hemorrhagic fever and can be transmitted between species (zoonotic). Discovered in 1969 when two missionary nurses died in Nigeria and today still occurs mainly in West Africa.		[[File:Lassa_virus.jpg\|thumb\|Lassa virus]]

			Lassa virus is a member of the virus family ''Arenaviridae'', a single-stranded RNA virus. The virus is the causative agent of a hemorrhagic fever and can be transmitted between species (zoonotic). Discovered in 1969 when two missionary nurses died in Nigeria and today still occurs mainly in West Africa.

	Death rates are high for women in the third trimester of pregnancy. Fetal death (95%) occurs in uterus of infected pregnant mothers.		Death rates are high for women in the third trimester of pregnancy. Fetal death (95%) occurs in uterus of infected pregnant mothers.

S8600021: Created page with "

2011-11-04T00:34:55Z

Created page with "<div style="background:#F5FFFA; border: 1px solid #CEF2E0; padding: 1em; margin: auto; width: 95%; float:left;"><div style="margin:0;background-color:#cef2e0;font-family:sans-ser..."

New page
<div style="background:#F5FFFA; border: 1px solid #CEF2E0; padding: 1em; margin: auto; width: 95%; float:left;"><div style="margin:0;background-color:#cef2e0;font-family:sans-serif;font-size:120%;font-weight:bold;border:1px solid #a3bfb1;text-align:left;color:#000;padding-left:0.4em;padding-top:0.2em;padding-bottom:0.2em;">Notice - Mark Hill</div>Currently this page is only a template and will be updated (this notice removed when completed).</div>

==Introduction==
Lassa virus is a member of the virus family Arenaviridae, a single-stranded RNA virus. The virus is the causative agent of a hemorrhagic fever and can be transmitted between species (zoonotic). Discovered in 1969 when two missionary nurses died in Nigeria and today still occurs mainly in West Africa.

Death rates are high for women in the third trimester of pregnancy. Fetal death (95%) occurs in uterus of infected pregnant mothers.

:{{Viral Links}}

==Some Recent Findings==
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==References==

<references/>

===Reviews===

<pubmed></pubmed>

===Articles===

===Search Pubmed===

June 2010

'''Search Pubmed:''' [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=Lassa%20Virus Lassa Virus] |
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== External Links ==
{{External Links}}

* [http://www.idsociety.org/Index.aspx Infectious Disease Society of America] (IDSA)

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[[Category:Abnormal Development]] [[Category:Environmental Abnormalities]] [[Category:Virus]]