Abnormal Development - Hypoxia - Revision history

Z8600021 at 23:41, 3 December 2019

2019-12-03T23:41:41Z

← Older revision		Revision as of 09:41, 4 December 2019
Line 73:		Line 73:
	{{#pmid:22241888}}		{{#pmid:22241888}}

			{{#pmid:17963271}}
	===Articles===		===Articles===

Z8600021 at 23:35, 3 December 2019

2019-12-03T23:35:05Z

← Older revision		Revision as of 09:35, 4 December 2019
Line 19:		Line 19:
	\|-bgcolor="F5FAFF"		\|-bgcolor="F5FAFF"
	\|		\|


			* '''Early Gestational Hypoxia and Adverse Developmental Outcomes'''{{#pmid:29105381\|PMID29105381}} "Hypoxia is a normal and essential part of embryonic development. However, this state may leave the embryo vulnerable to damage when oxygen supply is disturbed. Embryofetal response to hypoxia is dependent on duration and depth of hypoxia, as well as developmental stage. Early postimplantation rat embryos were resilient to hypoxia, with many surviving up to 1.5 hr of uterine clamping, while most mid-gestation embryos were dead after 1 hour of clamping. Survivors were small and many had a range of defects, principally terminal transverse limb reduction defects. Similar patterns of malformations occurred when embryonic hypoxia was induced by maternal hypoxia, interruption of uteroplacental flow, or perfusion and embryonic bradycardia. There is good evidence that high altitude pregnancies are associated with smaller babies and increased risk of some malformations, but these results are complicated by increased risk of pre-eclampsia. Early onset pre-eclampsia itself is associated with small for dates and increased risk of atrio-ventricular septal defects. Limb defects have clearly been associated with chorionic villus sampling, cocaine, and misoprostol use. Similar defects are also observed with increased frequency among fetuses who are homozygous for thalassemia. Drugs that block the potassium current, whether as the prime site of action or as a side effect, are highly teratogenic in experimental animals. They induce embryonic bradycardia, hypoxia, hemorrhage, and blisters, leading to transverse limb defects as well as craniofacial and cardiovascular defects. While evidence linking these drugs to birth defects in humans is not compelling, the reason may methodological rather than biological."

	* '''Clinical, genetic and environmental factors associated with congenital vertebral malformations'''{{#pmid:23653580\|PMID23653580}} "Congenital vertebral malformations (CVM) pose a significant health problem because they can be associated with spinal deformities, such as congenital {{scoliosis}} and kyphosis, in addition to various syndromes and other congenital malformations. ... Maternal diabetes during pregnancy most commonly contributes to the occurrence of CVM, followed by other factors such as hypoxia and anticonvulsant medications."		* '''Clinical, genetic and environmental factors associated with congenital vertebral malformations'''{{#pmid:23653580\|PMID23653580}} "Congenital vertebral malformations (CVM) pose a significant health problem because they can be associated with spinal deformities, such as congenital {{scoliosis}} and kyphosis, in addition to various syndromes and other congenital malformations. ... Maternal diabetes during pregnancy most commonly contributes to the occurrence of CVM, followed by other factors such as hypoxia and anticonvulsant medications."
	\|}		\|}

Z8600021 at 23:31, 3 December 2019

2019-12-03T23:31:27Z

← Older revision		Revision as of 09:31, 4 December 2019
Line 26:		Line 26:
	\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}		\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}

	Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Fetal+Hypoxia ''Fetal Hypoxia''] \| [http://www.ncbi.nlm.nih.gov/pubmed/?term=Maternal+Hypoxia ''Maternal Hypoxia'']		Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Fetal+Hypoxia ''Fetal Hypoxia''] \| [http://www.ncbi.nlm.nih.gov/pubmed/?term=Maternal+Hypoxia ''Maternal Hypoxia''] \| [http://www.ncbi.nlm.nih.gov/pubmed/?term=Developmental+Hypoxia ''Developmental Hypoxia''] \|

	\|}		\|}
			{\| class="wikitable mw-collapsible mw-collapsed"
			! Older papers
			\|-
			\| {{Older papers}}
			\|}
	==Musculoskeletal Effects==		==Musculoskeletal Effects==
	[[File:Axial_skeleton.jpg\|thumb\|Axial Skeleton]]		[[File:Axial_skeleton.jpg\|thumb\|Axial Skeleton]]

Z8600021 at 01:54, 7 March 2019

2019-03-07T01:54:09Z

← Older revision		Revision as of 11:54, 7 March 2019
Line 5:		Line 5:
	Hypoxia (hypoxiation or anoxemia) is the condition of reduced oxygen content. Postnatally, environmental hypoxia can effect the function/survival of many systems, while prenatal hypoxia (including birth) has been shown to have many detrimental effects for the growing fetus/neonate. It should be noted that normal prenatal development typically occurs in an environment that is hypoxic compared to the maternal or postnatal environment. The hypoxia discussed here refers to reduced maternal oxygen or fetal hypoxia below that occurring in normal development. Exposure to altitude hypoxia normally results in physiological responses that act to preserve maternal and fetal oxygenation.		Hypoxia (hypoxiation or anoxemia) is the condition of reduced oxygen content. Postnatally, environmental hypoxia can effect the function/survival of many systems, while prenatal hypoxia (including birth) has been shown to have many detrimental effects for the growing fetus/neonate. It should be noted that normal prenatal development typically occurs in an environment that is hypoxic compared to the maternal or postnatal environment. The hypoxia discussed here refers to reduced maternal oxygen or fetal hypoxia below that occurring in normal development. Exposure to altitude hypoxia normally results in physiological responses that act to preserve maternal and fetal oxygenation.

	Maternal smoking, in addition to vasoconstriction, has associated carbon monoxide inhalation that has also been suggested to interfere with delivery of oxygen to the fetus. (More? [[Abnormal Development - Smoking\|Smoking]])

	Historically, hypoxia was identified in growing mice and rats as influencing the growth of caudal vertebrae.~~<ref name=PMID4783417><pubmed>~~4783417~~</pubmed>~~\| ~~[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1271598/pdf/janat00310-0067.pdf PDF]</ref>~~ More recently hypoxia has now been shown to influence many different developing systems including neural, heart and skeletal systems.		Maternal {{smoking}}, in addition to vasoconstriction, has associated carbon monoxide inhalation that has also been suggested to interfere with delivery of oxygen to the fetus. (More? {{Smoking}})


			Historically, hypoxia was identified in growing mice and rats as influencing the growth of caudal vertebrae.{{#pmid:4783417\|PMID4783417}} More recently hypoxia has now been shown to influence many different developing systems including neural, heart and skeletal systems.


Line 24:		Line 26:
	\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}		\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}

	Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Fetal+Hypoxia ''Fetal Hypoxia'']		Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Fetal+Hypoxia ''Fetal Hypoxia''] \| [http://www.ncbi.nlm.nih.gov/pubmed/?term=Maternal+Hypoxia ''Maternal Hypoxia'']

	~~<pubmed limit=5>Fetal Hypoxia</pubmed>~~

	~~Search term:~~ [http://www.ncbi.nlm.nih.gov/pubmed/?term=Maternal+Hypoxia ''Maternal Hypoxia'']

	~~<pubmed limit=5>Maternal Hypoxia</pubmed>~~
	\|}		\|}

Line 38:		Line 35:


	:'''Links:''' ~~[[Musculoskeletal_System_-_Axial_Skeleton_Development\|~~Axial ~~Skeleton Development]]~~		:'''Links:''' {{Axial skeleton}}

	==Cardiac Effects==		==Cardiac Effects==

Z8600021 at 01:52, 7 March 2019

2019-03-07T01:52:34Z

← Older revision		Revision as of 11:52, 7 March 2019
Line 17:		Line 17:
	\|-bgcolor="F5FAFF"		\|-bgcolor="F5FAFF"
	\|		\|
	* '''Clinical, genetic and environmental factors associated with congenital vertebral malformations'''{{#pmid:23653580\|PMID23653580}} "Congenital vertebral malformations (CVM) pose a significant health problem because they can be associated with spinal deformities, such as congenital scoliosis and kyphosis, in addition to various syndromes and other congenital malformations. ... Maternal diabetes during pregnancy most commonly contributes to the occurrence of CVM, followed by other factors such as hypoxia and anticonvulsant medications."		* '''Clinical, genetic and environmental factors associated with congenital vertebral malformations'''{{#pmid:23653580\|PMID23653580}} "Congenital vertebral malformations (CVM) pose a significant health problem because they can be associated with spinal deformities, such as congenital {{scoliosis}} and kyphosis, in addition to various syndromes and other congenital malformations. ... Maternal diabetes during pregnancy most commonly contributes to the occurrence of CVM, followed by other factors such as hypoxia and anticonvulsant medications."
	\|}		\|}
	{\| class="wikitable mw-collapsible mw-collapsed"		{\| class="wikitable mw-collapsible mw-collapsed"

Z8600021 at 12:16, 19 March 2018

2018-03-19T12:16:40Z

← Older revision		Revision as of 22:16, 19 March 2018
Line 17:		Line 17:
	\|-bgcolor="F5FAFF"		\|-bgcolor="F5FAFF"
	\|		\|
	* '''Clinical, genetic and environmental factors associated with congenital vertebral malformations'''~~<ref name=PMID23653580><pubmed>~~23653580~~</pubmed>~~\| ~~[http://www.karger.com/Article/FullText/345329 Mol Syndromol.]</ref>~~ "Congenital vertebral malformations (CVM) pose a significant health problem because they can be associated with spinal deformities, such as congenital scoliosis and kyphosis, in addition to various syndromes and other congenital malformations. ... Maternal diabetes during pregnancy most commonly contributes to the occurrence of CVM, followed by other factors such as hypoxia and anticonvulsant medications."		* '''Clinical, genetic and environmental factors associated with congenital vertebral malformations'''{{#pmid:23653580\|PMID23653580}} "Congenital vertebral malformations (CVM) pose a significant health problem because they can be associated with spinal deformities, such as congenital scoliosis and kyphosis, in addition to various syndromes and other congenital malformations. ... Maternal diabetes during pregnancy most commonly contributes to the occurrence of CVM, followed by other factors such as hypoxia and anticonvulsant medications."
	\|}		\|}
	{\| class="wikitable mw-collapsible mw-collapsed"		{\| class="wikitable mw-collapsible mw-collapsed"
	! More recent papers		! More recent papers
	\|-		\|-
	\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}		\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}
Line 56:		Line 56:

	===Reviews===		===Reviews===
	~~<pubmed></pubmed>~~		{{#pmid:25009498}}
	~~<pubmed>25009498</pubmed>~~
	~~<pubmed>~~23627456~~</pubmed>~~		{{#pmid:23627456}}
	~~<pubmed>~~23034156~~</pubmed>~~
	~~<pubmed>~~22724609~~</pubmed>~~		{{#pmid:23034156}}
	~~<pubmed>~~22244654~~</pubmed>~~
	~~<pubmed>~~22241888~~</pubmed>~~		{{#pmid:22724609}}

			{{#pmid:22244654}}

			{{#pmid:22241888}}

	===Articles===		===Articles===
	~~<pubmed></pubmed>~~
	~~<pubmed></pubmed>~~


	===Search Pubmed===		===Search Pubmed===
Line 78:		Line 79:

	* Victor Chang Cardiac Research Institute - [http://www.victorchang.org.au/home/our-research/faculty-detail/?faculty_name=prof-sally-dunwoodie-2&division_name=development-stem-cell-biology Dunwoodie Lab]		* Victor Chang Cardiac Research Institute - [http://www.victorchang.org.au/home/our-research/faculty-detail/?faculty_name=prof-sally-dunwoodie-2&division_name=development-stem-cell-biology Dunwoodie Lab]

	~~----~~

	{{Environmental}}		{{Environmental}}

Z8600021 at 02:51, 28 August 2014

2014-08-28T02:51:20Z

← Older revision		Revision as of 12:51, 28 August 2014
Line 5:		Line 5:
	Hypoxia (hypoxiation or anoxemia) is the condition of reduced oxygen content. Postnatally, environmental hypoxia can effect the function/survival of many systems, while prenatal hypoxia (including birth) has been shown to have many detrimental effects for the growing fetus/neonate. It should be noted that normal prenatal development typically occurs in an environment that is hypoxic compared to the maternal or postnatal environment. The hypoxia discussed here refers to reduced maternal oxygen or fetal hypoxia below that occurring in normal development. Exposure to altitude hypoxia normally results in physiological responses that act to preserve maternal and fetal oxygenation.		Hypoxia (hypoxiation or anoxemia) is the condition of reduced oxygen content. Postnatally, environmental hypoxia can effect the function/survival of many systems, while prenatal hypoxia (including birth) has been shown to have many detrimental effects for the growing fetus/neonate. It should be noted that normal prenatal development typically occurs in an environment that is hypoxic compared to the maternal or postnatal environment. The hypoxia discussed here refers to reduced maternal oxygen or fetal hypoxia below that occurring in normal development. Exposure to altitude hypoxia normally results in physiological responses that act to preserve maternal and fetal oxygenation.

			Maternal smoking, in addition to vasoconstriction, has associated carbon monoxide inhalation that has also been suggested to interfere with delivery of oxygen to the fetus. (More? [[Abnormal Development - Smoking\|Smoking]])

	Historically, hypoxia was identified in growing mice and rats as influencing the growth of caudal vertebrae.<ref name=PMID4783417><pubmed>4783417</pubmed>\| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1271598/pdf/janat00310-0067.pdf PDF]</ref> More recently hypoxia has now been shown to influence many different developing systems including neural, heart and skeletal systems.		Historically, hypoxia was identified in growing mice and rats as influencing the growth of caudal vertebrae.<ref name=PMID4783417><pubmed>4783417</pubmed>\| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1271598/pdf/janat00310-0067.pdf PDF]</ref> More recently hypoxia has now been shown to influence many different developing systems including neural, heart and skeletal systems.

Z8600021 at 02:44, 28 August 2014

2014-08-28T02:44:25Z

← Older revision		Revision as of 12:44, 28 August 2014
Line 3:		Line 3:
	==Introduction==		==Introduction==
	[[File:Placenta_oxygen_exchange_levels.jpg\|thumb\|alt=Image of normal human oxygen exchange levels\|Human normal oxygen exchange levels.]]		[[File:Placenta_oxygen_exchange_levels.jpg\|thumb\|alt=Image of normal human oxygen exchange levels\|Human normal oxygen exchange levels.]]
	Hypoxia (hypoxiation or anoxemia) is the condition of reduced oxygen content. Postnatally environmental hypoxia can effect the function/survival of many systems, while prenatal hypoxia has been shown to have many detrimental effects for the growing fetus. It should be noted that normal prenatal development typically occurs in an environment that is hypoxic compared to the maternal or postnatal environment. The hypoxia discussed here refers to reduced maternal oxygen or fetal hypoxia below that occurring in normal development.		Hypoxia (hypoxiation or anoxemia) is the condition of reduced oxygen content. Postnatally, environmental hypoxia can effect the function/survival of many systems, while prenatal hypoxia (including birth) has been shown to have many detrimental effects for the growing fetus/neonate. It should be noted that normal prenatal development typically occurs in an environment that is hypoxic compared to the maternal or postnatal environment. The hypoxia discussed here refers to reduced maternal oxygen or fetal hypoxia below that occurring in normal development. Exposure to altitude hypoxia normally results in physiological responses that act to preserve maternal and fetal oxygenation.

Z8600021 at 02:41, 28 August 2014

2014-08-28T02:41:37Z

← Older revision		Revision as of 12:41, 28 August 2014
Line 55:		Line 55:

	===Reviews===		===Reviews===
			<pubmed></pubmed>
			<pubmed>25009498</pubmed>
			<pubmed>23627456</pubmed>
			<pubmed>23034156</pubmed>
			<pubmed>22724609</pubmed>
			<pubmed>22244654</pubmed>
			<pubmed>22241888</pubmed>

	===Articles===		===Articles===

Z8600021 at 02:26, 28 August 2014

2014-08-28T02:26:03Z

← Older revision		Revision as of 12:26, 28 August 2014
Line 2:		Line 2:
	{{Educational Warning}}		{{Educational Warning}}
	==Introduction==		==Introduction==
	Hypoxia (hypoxiation or anoxemia) is the condition of reduced oxygen content. Postnatally environmental hypoxia can effect the function/survival of many systems, while prenatal hypoxia has been shown to have many detrimental effects for the growing fetus.		[[File:Placenta_oxygen_exchange_levels.jpg\|thumb\|alt=Image of normal human oxygen exchange levels\|Human normal oxygen exchange levels.]]
			Hypoxia (hypoxiation or anoxemia) is the condition of reduced oxygen content. Postnatally environmental hypoxia can effect the function/survival of many systems, while prenatal hypoxia has been shown to have many detrimental effects for the growing fetus. It should be noted that normal prenatal development typically occurs in an environment that is hypoxic compared to the maternal or postnatal environment. The hypoxia discussed here refers to reduced maternal oxygen or fetal hypoxia below that occurring in normal development.


	Historically, hypoxia was identified in growing mice and rats as influencing the growth of caudal vertebrae.<ref name=PMID4783417><pubmed>4783417</pubmed>\| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1271598/pdf/janat00310-0067.pdf PDF]</ref> More recently hypoxia has now been shown to influence many different developing systems including neural, heart and skeletal systems.		Historically, hypoxia was identified in growing mice and rats as influencing the growth of caudal vertebrae.<ref name=PMID4783417><pubmed>4783417</pubmed>\| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1271598/pdf/janat00310-0067.pdf PDF]</ref> More recently hypoxia has now been shown to influence many different developing systems including neural, heart and skeletal systems.