ANAT2341 Lab 6 - Revision history

Z3485617 at 03:01, 11 Haziran 2020

2020-06-11T03:01:36Z

← Older revision		Revision as of 14:01, 11 Haziran 2020
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	\| width=185px valign=top\| [[File:Kirsty Walters.jpg\|180px]]		\| width=185px valign=top\| [[File:Kirsty Walters.jpg\|180px]]

	[https://research.unsw.edu.au/people/dr-kirsty-walters Dr ~~Kitsty~~ Walters]		[https://research.unsw.edu.au/people/dr-kirsty-walters Dr Kirsty Walters]

	\| Dr Kirsty Walters is a Senior Lecturer in Women’s and Children’s Health at the University of New South Wales (UNSW), Sydney, specialising in the field of female reproduction and ovarian function.		\| Dr Kirsty Walters is a Senior Lecturer in Women’s and Children’s Health at the University of New South Wales (UNSW), Sydney, specialising in the field of female reproduction and ovarian function.

Z3485617 at 03:00, 11 Haziran 2020

2020-06-11T03:00:39Z

← Older revision		Revision as of 14:00, 11 Haziran 2020
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	Dr Walters’ research involves using customized genetic mouse models in combination with clinical samples and trials to dissect out the fundamental mechanisms regulating female reproduction and polycystic ovary syndrome (PCOS). In particular, her research has focused on understanding the role androgens play in regulating female fertility and PCOS. Findings from this research will identify therapeutic targets for improved treatment of female infertility and the wide range of health issues associated with PCOS, including obesity, insulin resistance, type 2 diabetes and cardiovascular risk.		Dr Walters’ research involves using customized genetic mouse models in combination with clinical samples and trials to dissect out the fundamental mechanisms regulating female reproduction and polycystic ovary syndrome (PCOS). In particular, her research has focused on understanding the role androgens play in regulating female fertility and PCOS. Findings from this research will identify therapeutic targets for improved treatment of female infertility and the wide range of health issues associated with PCOS, including obesity, insulin resistance, type 2 diabetes and cardiovascular risk.
	\|}		\|}

	~~[[Media:Slides_for_Dr_K_Walters_embryology_lecture_2018_31.8.18.pdf\|'''Walters Lecture Slides''']]~~

	'''An Introduction to Polycystic Ovary Syndrome (PCOS)'''		'''An Introduction to Polycystic Ovary Syndrome (PCOS)'''

Z3485617 at 02:31, 1 November 2019

2019-11-01T02:31:10Z

← Older revision		Revision as of 13:31, 1 November 2019
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	~~== 2. Guest Lecturer~~ - Dr Kirsty Walters==		GUEST LECTURER - Dr Kirsty Walters

	{\|		{\|
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	[[Media:Slides_for_Dr_K_Walters_embryology_lecture_2018_31.8.18.pdf\|'''Walters Lecture Slides''']]		[[Media:Slides_for_Dr_K_Walters_embryology_lecture_2018_31.8.18.pdf\|'''Walters Lecture Slides''']]

	==An Introduction to Polycystic Ovary Syndrome (PCOS)==		'''An Introduction to Polycystic Ovary Syndrome (PCOS)'''

	<html5media width="600" height="400">https://www.youtube.com/embed/NhyYZCBq5A8</html5media>		<html5media width="600" height="400">https://www.youtube.com/embed/NhyYZCBq5A8</html5media>

	==Polycystic Ovary Syndrome Mouse Model==		'''Polycystic Ovary Syndrome Mouse Model'''
	{{#pmid:28320971}}		{{#pmid:28320971}}

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	\|}		\|}

	==Role of Androgens in the Ovary==		'''Role of Androgens in the Ovary'''
	{{#pmid:28687450}}		{{#pmid:28687450}}

	:"It has been well established for decades that androgens, namely {{testosterone}} (T) plays an important role in female reproductive physiology as the precursor for oestradiol (E2). However, in the last decade a direct role for androgens, acting via the androgen receptor (AR), in female reproductive function has been confirmed. Deciphering the specific roles of androgens in ovarian function has been hindered as complete androgen resistant females cannot be generated by natural breeding. In addition, androgens can be converted into estrogens which has caused confusion when interpreting findings from pharmacological studies, as observed effects could have been mediated via the AR or estrogen receptor. The creation and analysis of genetic {{mouse}} models with global and cell-specific disruption of the Ar gene, the sole mediator of pure androgenic action, has now allowed the elucidation of a role for AR-mediated androgen actions in the regulation of normal and pathological ovarian function. This review aims to summarize findings from clinical, animal, pharmacological and novel genetic AR mouse models to provide an understanding of the important roles androgens play in the {{ovary}}, as well as providing insights into the human implications of these roles."		:"It has been well established for decades that androgens, namely {{testosterone}} (T) plays an important role in female reproductive physiology as the precursor for oestradiol (E2). However, in the last decade a direct role for androgens, acting via the androgen receptor (AR), in female reproductive function has been confirmed. Deciphering the specific roles of androgens in ovarian function has been hindered as complete androgen resistant females cannot be generated by natural breeding. In addition, androgens can be converted into estrogens which has caused confusion when interpreting findings from pharmacological studies, as observed effects could have been mediated via the AR or estrogen receptor. The creation and analysis of genetic {{mouse}} models with global and cell-specific disruption of the Ar gene, the sole mediator of pure androgenic action, has now allowed the elucidation of a role for AR-mediated androgen actions in the regulation of normal and pathological ovarian function. This review aims to summarize findings from clinical, animal, pharmacological and novel genetic AR mouse models to provide an understanding of the important roles androgens play in the {{ovary}}, as well as providing insights into the human implications of these roles."

	==References==		'''References'''

	{{#pmid:29635226}}		{{#pmid:29635226}}

Z3485617 at 02:29, 1 November 2019

2019-11-01T02:29:54Z

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	PRACTICAL CLASS PROGRAM:		PRACTICAL CLASS PROGRAM:

	• Weekly Quiz + revision (15 minutes)		* Weekly Quiz + revision (15 minutes)
	• Practical class activities (45 minutes)		* Practical class activities (45 minutes)
	• Guest Lecture by A/Prof Kirsty Walters		* Guest Lecture by A/Prof Kirsty Walters
	• Practical Class Revision (15 minutes)		* Practical Class Revision (15 minutes)

	PRACTICAL CLASS ACTIVITIES		PRACTICAL CLASS ACTIVITIES
	1. Virtual embryo dissections		* Virtual embryo dissections
	2. SmartSparrow module		* SmartSparrow module
	3. Specimens of human birth abnormalities		* Specimens of human birth abnormalities

	LEARNING OBJECTIVES:		LEARNING OBJECTIVES:
	• Understand development of the reproductive system.		* Understand development of the reproductive system.
	• Understand development of the renal system.		* Understand development of the renal system.
	• Understand the developmental basis of abnormalities associated with placental development and the reproductive and urinary systems.		* Understand the developmental basis of abnormalities associated with placental development and the reproductive and urinary systems.

Z3485617 at 02:28, 1 November 2019

2019-11-01T02:28:55Z

← Older revision		Revision as of 13:28, 1 November 2019
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			PRACTICAL CLASS PROGRAM:

	== 1. ~~QUIZ ==~~		• Weekly Quiz + revision (15 minutes)
			• Practical class activities (45 minutes)
			• Guest Lecture by A/Prof Kirsty Walters
			• Practical Class Revision (15 minutes)

			PRACTICAL CLASS ACTIVITIES
			1. Virtual embryo dissections
			2. SmartSparrow module
			3. Specimens of human birth abnormalities

			LEARNING OBJECTIVES:
			• Understand development of the reproductive system.
			• Understand development of the renal system.
			• Understand the developmental basis of abnormalities associated with placental development and the reproductive and urinary systems.

Z8600021: /* References */

2019-07-16T00:37:25Z

References

← Older revision		Revision as of 11:37, 16 July 2019
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	'''Dihydrotestosterone''' - The hormonally active form of testosterone (male sex hormone) produced by enzyme (5-alpha reductase) conversion. In the male embryo, this can occur in the genital skin which then supports external genital development. In the adult, this conversion occurs in a number of different tissues. A known treatment for prostate cancer include 5-alpha reductase inhibitors.		'''Dihydrotestosterone''' - The hormonally active form of testosterone (male sex hormone) produced by enzyme (5-alpha reductase) conversion. In the male embryo, this can occur in the genital skin which then supports external genital development. In the adult, this conversion occurs in a number of different tissues. A known treatment for prostate cancer include 5-alpha reductase inhibitors.
	\|}		\|}

			==Role of Androgens in the Ovary==
			{{#pmid:28687450}}

			:"It has been well established for decades that androgens, namely {{testosterone}} (T) plays an important role in female reproductive physiology as the precursor for oestradiol (E2). However, in the last decade a direct role for androgens, acting via the androgen receptor (AR), in female reproductive function has been confirmed. Deciphering the specific roles of androgens in ovarian function has been hindered as complete androgen resistant females cannot be generated by natural breeding. In addition, androgens can be converted into estrogens which has caused confusion when interpreting findings from pharmacological studies, as observed effects could have been mediated via the AR or estrogen receptor. The creation and analysis of genetic {{mouse}} models with global and cell-specific disruption of the Ar gene, the sole mediator of pure androgenic action, has now allowed the elucidation of a role for AR-mediated androgen actions in the regulation of normal and pathological ovarian function. This review aims to summarize findings from clinical, animal, pharmacological and novel genetic AR mouse models to provide an understanding of the important roles androgens play in the {{ovary}}, as well as providing insights into the human implications of these roles."

	==References==		==References==

Z8600021: /* 2. Guest Lecturer - Dr Kirsty Walters */

2018-09-03T03:37:56Z

2. Guest Lecturer - Dr Kirsty Walters

← Older revision		Revision as of 14:37, 3 September 2018
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	\|}		\|}

	[[Media:Slides_for_Dr_K_Walters_embryology_lecture_2018_31.8.18.pdf\|Walters Lecture Slides]]		[[Media:Slides_for_Dr_K_Walters_embryology_lecture_2018_31.8.18.pdf\|'''Walters Lecture Slides''']]

	==An Introduction to Polycystic Ovary Syndrome (PCOS)==		==An Introduction to Polycystic Ovary Syndrome (PCOS)==

Z3485617 at 01:43, 31 August 2018

2018-08-31T01:43:02Z

← Older revision		Revision as of 12:43, 31 August 2018
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	Dr Walters’ research involves using customized genetic mouse models in combination with clinical samples and trials to dissect out the fundamental mechanisms regulating female reproduction and polycystic ovary syndrome (PCOS). In particular, her research has focused on understanding the role androgens play in regulating female fertility and PCOS. Findings from this research will identify therapeutic targets for improved treatment of female infertility and the wide range of health issues associated with PCOS, including obesity, insulin resistance, type 2 diabetes and cardiovascular risk.		Dr Walters’ research involves using customized genetic mouse models in combination with clinical samples and trials to dissect out the fundamental mechanisms regulating female reproduction and polycystic ovary syndrome (PCOS). In particular, her research has focused on understanding the role androgens play in regulating female fertility and PCOS. Findings from this research will identify therapeutic targets for improved treatment of female infertility and the wide range of health issues associated with PCOS, including obesity, insulin resistance, type 2 diabetes and cardiovascular risk.
	\|}		\|}

			[[Media:Slides_for_Dr_K_Walters_embryology_lecture_2018_31.8.18.pdf\|Walters Lecture Slides]]

	==An Introduction to Polycystic Ovary Syndrome (PCOS)==		==An Introduction to Polycystic Ovary Syndrome (PCOS)==

Z8600021: /* 2. Guest Lecturer - Dr Kirsty Walters */

2018-07-19T05:20:56Z

2. Guest Lecturer - Dr Kirsty Walters

← Older revision		Revision as of 16:20, 19 July 2018
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	== 2. Guest Lecturer - Dr Kirsty Walters==		== 2. Guest Lecturer - Dr Kirsty Walters==

	{\|		{\|
	\| width=185px valign=top\| [[File:Kirsty Walters.jpg\|180px]]		\| width=185px valign=top\| [[File:Kirsty Walters.jpg\|180px]]
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	\| Dr Kirsty Walters is a Senior Lecturer in Women’s and Children’s Health at the University of New South Wales (UNSW), Sydney, specialising in the field of female reproduction and ovarian function.		\| Dr Kirsty Walters is a Senior Lecturer in Women’s and Children’s Health at the University of New South Wales (UNSW), Sydney, specialising in the field of female reproduction and ovarian function.



	Background:		Background:

	Dr Walters was awarded her PhD in 2005 from Edinburgh University, Scotland, and was then recruited by the ANZAC Research Institute (ARI) to undertake a post-doctoral position investigating the role androgens play in regulating female reproduction and physiology. In February 2016 the UNSW recruited her to head up the Ovarian Biology Laboratory based in the Wallace Wurth, which forms part of the world-leading biomedical precinct at UNSW.		Dr Walters was awarded her PhD in 2005 from Edinburgh University, Scotland, and was then recruited by the ANZAC Research Institute (ARI) to undertake a post-doctoral position investigating the role androgens play in regulating female reproduction and physiology. In February 2016 the UNSW recruited her to head up the Ovarian Biology Laboratory based in the Wallace Wurth, which forms part of the world-leading biomedical precinct at UNSW.



	Research interests:		Research interests:

Z8600021: /* 2. Guest Lecturer - Dr Kirsty Walters */

2018-07-19T05:20:37Z

2. Guest Lecturer - Dr Kirsty Walters

← Older revision		Revision as of 16:20, 19 July 2018
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	== 2. Guest Lecturer - Dr Kirsty Walters==		== 2. Guest Lecturer - Dr Kirsty Walters==
	{\|		{\|
	\| width=185px\| [[File:Kirsty Walters.jpg\|180px]]		\| width=185px valign=top\| [[File:Kirsty Walters.jpg\|180px]]

	[https://research.unsw.edu.au/people/dr-kirsty-walters Dr Kitsty Walters]		[https://research.unsw.edu.au/people/dr-kirsty-walters Dr Kitsty Walters]