2016 Group Project 2 - Revision history

Z8600021 at 23:32, 6 August 2018

2018-08-06T23:32:51Z

← Older revision		Revision as of 09:32, 7 August 2018
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	===References===		===References===
	<references/>		<references/>


			[[Category:Notch]]

Z8600021: Protected "2016 Group Project 2" ([Edit=Allow only administrators] (indefinite) [Move=Allow only administrators] (indefinite))

2016-10-27T23:07:10Z

Protected "2016 Group Project 2" ([Edit=Allow only administrators] (indefinite) [Move=Allow only administrators] (indefinite))

← Older revision	Revision as of 09:07, 28 October 2016
(No difference)

Z3462474: /* Non-canonical pathway */

2016-10-27T10:35:50Z

Non-canonical pathway

← Older revision		Revision as of 20:35, 27 October 2016
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	{\| class="pretty table"		{\| class="pretty table"
	\|-		\|-bgcolor="CEDFF2"
	\| colspan="5" align="center" \| <big>Examples of Non-Canonical Notch Signalling</big> <small>(adapted from Table 1<ref name="PMID22397947"/>)		\| colspan="5" align="center" \| <big>Examples of Non-Canonical Notch Signalling</big> <small>(adapted from Table 1<ref name="PMID22397947"/>)
	\|- align="center"		\|- align="center" bgcolor="CEDFF2"
	\| width="75" \| '''Species'''		\| width="75" \| '''Species'''
	\| width="300" \| '''Cell type'''		\| width="300" \| '''Cell type'''
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	\| '''Function'''		\| '''Function'''
	\| '''Interacting molecule/signalling pathway'''		\| '''Interacting molecule/signalling pathway'''
	\|-		\|-bgcolor="F5FAFF"
	\| Human		\| Human
	\| Human embryonic stem cells (''in vitro'')		\| Human embryonic stem cells (''in vitro'')
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	\| Negative regulation of Wnt signalling		\| Negative regulation of Wnt signalling
	\| Active β-catenin/Wnt signalling		\| Active β-catenin/Wnt signalling
	\|-		\|-bgcolor="F5FAFF"
	\| T-cells		\| T-cells
	\| CSL		\| CSL
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	\| HES1 activation and MCK inhibition		\| HES1 activation and MCK inhibition
	\| HES1 and MCK		\| HES1 and MCK
	\|-		\|-bgcolor="F5FAFF"
	\| Skin progenitor cells		\| Skin progenitor cells
	\| CSL		\| CSL
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	\| Slug expression		\| Slug expression
	\| Slug		\| Slug
	\|-		\|-bgcolor="F5FAFF"
	\| Frog		\| Frog
	\| Embryo		\| Embryo
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	\| Negative regulation of Wnt signalling		\| Negative regulation of Wnt signalling
	\| Active β-catenin/Wnt signalling		\| Active β-catenin/Wnt signalling
	\|-		\|-bgcolor="F5FAFF"
	\| CSL		\| CSL
	\| Inhibition of ligand function		\| Inhibition of ligand function
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	\| Muscle precursor selection		\| Muscle precursor selection
	\| Wnt signalling		\| Wnt signalling
	\|-		\|-bgcolor="F5FAFF"
	\| Embryo		\| Embryo
	\| CSL		\| CSL

Z5015014: /* Non-canonical pathway */

2016-10-27T09:42:57Z

Non-canonical pathway

← Older revision		Revision as of 19:42, 27 October 2016
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	\| β-catenin/Wnt signalling		\| β-catenin/Wnt signalling
	\|-		\|-
	\| rowspan="4" \| Fly		\| rowspan="5" \| Fly
	\| Wing primordium		\| rowspan="2" \| Wing primordium
	\| Ligand, ~~CSL<br>~~CSL		\| Ligand, CSL
	\| Negative regulation of Wnt signalling~~<br>Inhibition of ligand function~~		\| Negative regulation of Wnt signalling
	\| Active β-catenin/Wnt signalling~~<br>~~Serrate		\| Active β-catenin/Wnt signalling
			\|-
			\| CSL
			\| Inhibition of ligand function
			\| Serrate
	\|-		\|-
	\| Muscle progenitor cells		\| Muscle progenitor cells

Z3462474: /* Want to Read More About Notch? */

2016-10-27T09:41:41Z

Want to Read More About Notch?

← Older revision		Revision as of 19:41, 27 October 2016
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	\|}		\|}
	{\| class="wikitable mw-collapsible mw-collapsed"		{\| class="wikitable mw-collapsible mw-collapsed"
	! <big>Notch ~~Modulation~~ for ~~Therapy~~</big>		! <big>Notch modulation for therapy</big>
	\|-		\|-
	\|As you would have read in the [[#Abnormalities in Notch signalling\| Abnormalities in Notch Signalling]] section, Notch can play different roles in cancer development. An interesting review further elucidates that modulation of Notch signalling is actually being investigated as a potential target for cancer therapy:<br><br>		\|As you would have read in the [[#Abnormalities in Notch signalling\| Abnormalities in Notch Signalling]] section, Notch can play different roles in cancer development. An interesting review further elucidates that modulation of Notch signalling is actually being investigated as a potential target for cancer therapy:<br><br>

Z5015014: /* History */

2016-10-27T09:37:45Z

History

← Older revision		Revision as of 19:37, 27 October 2016
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	\| 1917		\| 1917
	\| First allele of ''Notch'' is identified by Thomas Hunt Morgan<ref>Morgan, T. H. (1917). The theory of the gene. ''The American Naturalist'', 51(609), 513-544.</ref>		\| First allele of ''Notch'' is identified by Thomas Hunt Morgan<ref>Morgan, T. H. (1917). The theory of the gene. ''The American Naturalist'', 51(609), 513-544.</ref>
	\|-bgcolor="FAF5FF"		\|-bgcolor="FAF5FF"
	\|-
	\| 1930s		\| 1930s
	\| Donald F. Poulson conducts research into the involvement of ''Notch'' in development.<ref><pubmed>16588136</pubmed></ref>		\| Donald F. Poulson conducts research into the involvement of ''Notch'' in development.<ref><pubmed>16588136</pubmed></ref>
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	\| An investigation by W.J. Welshons confirmed that the locus of Notch is contained within the 3C7 band of the X chromosome.<ref><pubmed>13635554</pubmed></ref>		\| An investigation by W.J. Welshons confirmed that the locus of Notch is contained within the 3C7 band of the X chromosome.<ref><pubmed>13635554</pubmed></ref>
	\|-bgcolor="FAF5FF"		\|-bgcolor="FAF5FF"
	\|-
	\| 1983		\| 1983
	\| DNA sequences belonging to the Notch locus cloned and determined that RNA is required for the function of the wild type Notch. Further insight developed into the function of Notch and its role in differentiation and regeneration.<ref><pubmed>6403942</pubmed></ref>		\| DNA sequences belonging to the Notch locus cloned and determined that RNA is required for the function of the wild type Notch. Further insight developed into the function of Notch and its role in differentiation and regeneration.<ref><pubmed>6403942</pubmed></ref>
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	\| 1986		\| 1986
	\| The molecular analysis and sequence of the Notch locus was determined by Michael W. Young and his team. A relationship was identified between the protein encoded by the major Notch transcript and mammalian clotting and growth factors.<ref><pubmed>3097517</pubmed></ref>		\| The molecular analysis and sequence of the Notch locus was determined by Michael W. Young and his team. A relationship was identified between the protein encoded by the major Notch transcript and mammalian clotting and growth factors.<ref><pubmed>3097517</pubmed></ref>
	\|-bgcolor="FAF5FF"		\|-bgcolor="FAF5FF"
	\|-
	\| 1989		\| 1989
	\| Neurogenic loci "Delta" and "Mastermind" identified and research conducted to search for genes which may have an interaction with the Notch protein. It was confirmed that mutations in these loci will affect neurogenesis.<ref><pubmed>2338245</pubmed></ref>		\| Neurogenic loci "Delta" and "Mastermind" identified and research conducted to search for genes which may have an interaction with the Notch protein. It was confirmed that mutations in these loci will affect neurogenesis.<ref><pubmed>2338245</pubmed></ref>
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	\| 2012		\| 2012
	\| The Notch ligand Jag1 was expressed in PA6 cells and showed demonstrated that the ability for the cells to differentiate was interrupted by the Notch signalling inhibition pathway. <ref><pubmed>22558462</pubmed></ref>		\| The Notch ligand Jag1 was expressed in PA6 cells and showed demonstrated that the ability for the cells to differentiate was interrupted by the Notch signalling inhibition pathway. <ref><pubmed>22558462</pubmed></ref>
	\|-		\|-bgcolor="FAF5FF"
	\| 2014		\| 2014
	\| Breakthrough in the applications of the Notch signalling pathway. Evidence emerged showing an association between the Notch signalling pathway and gastric cancer and found that Notch1 and Notch2 pathways have been activated in gastric cancer.<ref><pubmed>25083094</pubmed></ref>		\| Breakthrough in the applications of the Notch signalling pathway. Evidence emerged showing an association between the Notch signalling pathway and gastric cancer and found that Notch1 and Notch2 pathways have been activated in gastric cancer.<ref><pubmed>25083094</pubmed></ref>

Z5015014: /* Non-canonical pathway */

2016-10-27T09:34:32Z

Non-canonical pathway

@@ Line 67: / Line 67: @@
 Recent research has shown that Notch signalling plays crucial roles for cellular differentiation during development through γ-secretase-dependent intramembrane proteolysis followed by transcription of target genes. Hayashi et al. (2016) uncovered a ligand-dependent but γ-secretase-independent, non-canonical Notch signalling involved in presynaptic protein expression in postmitotic neurons.<ref name="PMID27040987"><pubmed>27040987</pubmed></ref>
 <br><br>
 ====Transcriptional regulation of Notch signalling====

Z5015014: /* Summary of Functions of Proteins Involved in Notch Signalling (adapted from Table 117761886) */

2016-10-27T09:00:10Z

Summary of Functions of Proteins Involved in Notch Signalling (adapted from Table 117761886)

← Older revision		Revision as of 19:00, 27 October 2016
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	</quiz>		</quiz>

	===Summary of Functions of Proteins Involved in Notch Signalling <small>(adapted from Table 1<ref name="PMID17761886"><pubmed>17761886</pubmed></ref>)</small>===		===Summary of Functions of Proteins Involved in Notch Signalling <small>(adapted from Table 1<ref name="PMID17761886">As reviewed by <pubmed>17761886</pubmed></ref>)</small>===
	{\| class="pretty table"		{\| class="pretty table"
	\|-bgcolor="a3bfb1"		\|-bgcolor="a3bfb1"

Z5015014: fixed a duplicate reference

2016-10-27T08:56:52Z

fixed a duplicate reference

← Older revision		Revision as of 18:56, 27 October 2016
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	<br><br>		<br><br>

	[[File:Notch animals.png\|thumb\|450px\|right\|alt=Animals Whose Developmental Processes are Affected by Notch.\|'''Animals Whose Developmental Processes are Affected by Notch.''' This is a simplified representation of a few examples of the animals (Drosophila flies<ref name=PMID21447553><pubmed>21447553</pubmed></ref>, C. elegans<ref name=PMID18599512><pubmed>18599512</pubmed></ref>, and the zebrafish<ref><pubmed>23840804</pubmed></ref>) in which development is influenced by the Notch signalling pathway, and their scientific names.]]		[[File:Notch animals.png\|thumb\|450px\|right\|alt=Animals Whose Developmental Processes are Affected by Notch.\|'''Animals Whose Developmental Processes are Affected by Notch.''' This is a simplified representation of a few examples of the animals (Drosophila flies<ref name=PMID21447553><pubmed>21447553</pubmed></ref>, C. elegans<ref name=PMID18599512><pubmed>18599512</pubmed></ref>, and the zebrafish<ref name="PMID23840804"><pubmed>23840804</pubmed></ref>) in which development is influenced by the Notch signalling pathway, and their scientific names.]]

	====''Drosophila melanogaster''====		====''Drosophila melanogaster''====
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	'''(The Zebrafish)'''		'''(The Zebrafish)'''

	The expression of Notch in the myogenic region and apical ectodermal ridge (AER) of the developing zebrafish fin is similar to what has been observed in developing chicken and mouse limbs, which shows how highly conserved the role of Notch signalling is in the development of appendages in vertebrates. During zebrafish embryogenesis, the timing and positioning of fin formation are dependent on Notch signalling. Notch is also involved in the actual processes of fin formation, such as AER signalling, chondrogenic differentiation, and myogenesis. In zebrafish embryos with defective Notch signalling, it was observed that the skeletal muscle fibres were thin and fragmented and the structure of the sarcomeres was significantly compromised. <ref name="PMID23840804"~~><pubmed>23840804<~~/~~pubmed></ref~~>		The expression of Notch in the myogenic region and apical ectodermal ridge (AER) of the developing zebrafish fin is similar to what has been observed in developing chicken and mouse limbs, which shows how highly conserved the role of Notch signalling is in the development of appendages in vertebrates. During zebrafish embryogenesis, the timing and positioning of fin formation are dependent on Notch signalling. Notch is also involved in the actual processes of fin formation, such as AER signalling, chondrogenic differentiation, and myogenesis. In zebrafish embryos with defective Notch signalling, it was observed that the skeletal muscle fibres were thin and fragmented and the structure of the sarcomeres was significantly compromised. <ref name="PMID23840804"/>

	{\| class="wikitable mw-collapsible mw-collapsed"		{\| class="wikitable mw-collapsible mw-collapsed"
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	-   Caenorhabditis elegans		-   Caenorhabditis elegans
	+   Danio rerio		+   Danio rerio
	\|\| Remember, it was observed in one study that the skeletal muscle fibres of zebrafish (Danio rerio) were thin and fragmented and the structure of their sarcomeres were significantly compromised.<ref~~><pubmed>23840804<~~/~~pubmed></ref~~>		\|\| Remember, it was observed in one study that the skeletal muscle fibres of zebrafish (Danio rerio) were thin and fragmented and the structure of their sarcomeres were significantly compromised.<ref name="PMID23840804"/>
	</quiz>		</quiz>

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	[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159580/ '''Not(ch) just development: Notch signalling in the adult brain.''']		[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159580/ '''Not(ch) just development: Notch signalling in the adult brain.''']

	This review explains that the Notch signalling pathway, which is so often regarded as a major molecular player in development, actually has important functions related to neural cells in the adult. As you would have read in the [[#Abnormalities in Notch signalling\| Abnormalities in Notch Signalling]] section, Notch abnormalities are involved in a number of diseases, which underlines its importance in maintaining adult brain function. Some highlights of this review are: Figure 2 provides a schematic representation of precise roles Notch activation can play in the adult brain; explanations of the ways that Notch influences brain plasticity; and the discussion of conflicting results of studies exploring the role of Notch in stroke recovery.<ref name=PMID21505516><pubmed>21505516</pubmed></ref>		This review explains that the Notch signalling pathway, which is so often regarded as a major molecular player in development, actually has important functions related to neural cells in the adult. As you would have read in the [[#Abnormalities in Notch signalling\| Abnormalities in Notch Signalling]] section, Notch abnormalities are involved in a number of diseases, which underlines its importance in maintaining adult brain function. Some highlights of this review are: Figure 2 provides a schematic representation of precise roles Notch activation can play in the adult brain; explanations of the ways that Notch influences brain plasticity; and the discussion of conflicting results of studies exploring the role of Notch in stroke recovery.<ref name=PMID21505516>As reviewed by <pubmed>21505516</pubmed></ref>
	\|}		\|}
	{\| class="wikitable mw-collapsible mw-collapsed"		{\| class="wikitable mw-collapsible mw-collapsed"

Z5014803 at 08:42, 27 October 2016

2016-10-27T08:42:24Z

← Older revision		Revision as of 18:42, 27 October 2016
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	\| 2012		\| 2012
	\| The Notch ligand Jag1 was expressed in PA6 cells and showed demonstrated that the ability for the cells to differentiate was interrupted by the Notch signalling inhibition pathway. <ref><pubmed>22558462</pubmed></ref>		\| The Notch ligand Jag1 was expressed in PA6 cells and showed demonstrated that the ability for the cells to differentiate was interrupted by the Notch signalling inhibition pathway. <ref><pubmed>22558462</pubmed></ref>
			\|-
			\| 2014
			\| Breakthrough in the applications of the Notch signalling pathway. Evidence emerged showing an association between the Notch signalling pathway and gastric cancer and found that Notch1 and Notch2 pathways have been activated in gastric cancer.<ref><pubmed>25083094</pubmed></ref>
	\|}		\|}