2012 Group Project 3 - Revision history

Z8600021: Protected "2012 Group Project 3" ([edit=sysop] (indefinite) [move=sysop] (indefinite))

2012-10-05T08:31:39Z

Protected "2012 Group Project 3" ([edit=sysop] (indefinite) [move=sysop] (indefinite))

← Older revision	Revision as of 18:31, 5 October 2012
(No difference)

Z3332337: /* FGF signalling and genes */

2012-10-05T03:30:38Z

FGF signalling and genes

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	{\|		{\|
	\| [[File:Figure 1 Spry1-2.jpeg\|160px\|thumb\|Location and Number of CVP]]		\| [[File:Figure 1 Spry1-2.jpeg\|160px\|thumb\|Location and Number of CVP]]
	\| [[File:CVP of WT(top) and DKO(bottom) mice with H&E and SEM.png\|thumb\|]]		\| [[File:CVP of WT(top) and DKO(bottom) mice with H&E and SEM.png\|thumb\|CVP of WT(top) and DKO(bottom) mice with H&E and SEM]]

	\|-		\|-

Z3332337: /* FGF signalling and genes */

2012-10-05T03:29:49Z

FGF signalling and genes

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	By knocking out ''Spry'' genes using mice which had both ''Spry1'' and ''Spry2'' knocked out showed that the number of CVP doubled. However, when Fibroblast [[#Glossary \|'''Growth Factor''']] gene ("Fgf10") was absent, the number of CVP was significantly reduced, if not completely absent. The correlation between ''Spry1/2'' and ''Fgf10'' is that ''Spry1/2'' antagonizes "Fgf10" to limit the size of the CVP progenitor placode. Exclusive expression of ''Fgf10'' in the [[#Glossary \|'''mesenchyme''']] is necessary for the formation of CVP.		By knocking out ''Spry'' genes using mice which had both ''Spry1'' and ''Spry2'' knocked out showed that the number of CVP doubled. However, when Fibroblast [[#Glossary \|'''Growth Factor''']] gene ("Fgf10") was absent, the number of CVP was significantly reduced, if not completely absent. The correlation between ''Spry1/2'' and ''Fgf10'' is that ''Spry1/2'' antagonizes "Fgf10" to limit the size of the CVP progenitor placode. Exclusive expression of ''Fgf10'' in the [[#Glossary \|'''mesenchyme''']] is necessary for the formation of CVP.

Z3332337: /* FGF signalling and genes */

2012-10-05T03:27:51Z

FGF signalling and genes

← Older revision		Revision as of 13:27, 5 October 2012
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	{\|		{\|
	\| [[File:Figure 1 Spry1-2.jpeg\|160px\|thumb\|]]		\| [[File:Figure 1 Spry1-2.jpeg\|160px\|thumb\|Location and Number of CVP]]
	\| [[File:CVP of WT(top) and DKO(bottom) mice with H&E and SEM.png\|thumb\|]]		\| [[File:CVP of WT(top) and DKO(bottom) mice with H&E and SEM.png\|thumb\|]]

	\|-		\|-
	\| <center>~~[[Location and Number of CVP]]~~</center>		\| <center></center>
	\| <center>~~[[CVP of WT(top) and DKO(bottom) mice with H&E and SEM]]~~</center>		\| <center></center>

	\|}		\|}

Z3332337: /* FGF signalling and genes */

2012-10-05T03:25:04Z

FGF signalling and genes

← Older revision		Revision as of 13:25, 5 October 2012
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	{\|		{\|
	\| [[File:Figure 1 Spry1-2.jpeg\|160px\|]]		\| [[File:Figure 1 Spry1-2.jpeg\|160px\|thumb\|]]
	\| [[File:CVP of WT(top) and DKO(bottom) mice with H&E and SEM.png]]		\| [[File:CVP of WT(top) and DKO(bottom) mice with H&E and SEM.png\|thumb\|]]

	\|-		\|-
	\| <center>[[Location and Number of CVP]]</center>		\| <center>[[Location and Number of CVP]]</center>
	\| <center>[[CVP of WT(top) and DKO(bottom) mice with H&E and SEM~~.png~~]]</center>		\| <center>[[CVP of WT(top) and DKO(bottom) mice with H&E and SEM]]</center>

	\|}		\|}

Z3332337: /* Current Research */

2012-10-05T03:18:55Z

Current Research

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	Above it is discussed that taste buds are derived from neurogenic endoderm, but there is the idea that taste buds are derived from the local lingual epithelium. Stone, et al 1995 <pubmed>7892199</pubmed></ref> put forth this view using transgenic X chromosome-inactivation mosiac mice. These female mice have half their cells expressing Beta-galactosidase and the other half inactive Beta-galactosidase. The active cells would be expressed as blue, the inactive cells red. Additionally, this trait was inheritable to daughter cells.		Above it is discussed that taste buds are derived from neurogenic endoderm, but there is the idea that taste buds are derived from the local lingual epithelium. Stone, et al 1995 <ref><pubmed>7892199</pubmed></ref> put forth this view using transgenic X chromosome-inactivation mosiac mice. These female mice have half their cells expressing Beta-galactosidase and the other half inactive Beta-galactosidase. The active cells would be expressed as blue, the inactive cells red. Additionally, this trait was inheritable to daughter cells.

	This method was used to show that cell populations which contained only blue or red cells could have progenitor cells migrate in. If the progenitor cell had the same colour, then it would be from the same origin. If not, a different progenitor origin. They found that the cells are likely to originate from local epithelium due to local tissue interactions. However, it was also found that lingual epithelium which had the potential for form taste buds were not necessarily from ectodermal or endodermal origins.		This method was used to show that cell populations which contained only blue or red cells could have progenitor cells migrate in. If the progenitor cell had the same colour, then it would be from the same origin. If not, a different progenitor origin. They found that the cells are likely to originate from local epithelium due to local tissue interactions. However, it was also found that lingual epithelium which had the potential for form taste buds were not necessarily from ectodermal or endodermal origins.

Z3332337: /* Current Research */

2012-10-05T03:17:44Z

Current Research

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	[[File:Developing_tongue_histology_001.jpg\|right\|thumb\|200px\|HIstological stain of a developing rat tongue]]		[[File:Developing_tongue_histology_001.jpg\|right\|thumb\|200px\|HIstological stain of a developing rat tongue]]


			'''Controversial View of Origins of Taste Cells'''


			Above it is discussed that taste buds are derived from neurogenic endoderm, but there is the idea that taste buds are derived from the local lingual epithelium. Stone, et al 1995 <pubmed>7892199</pubmed></ref> put forth this view using transgenic X chromosome-inactivation mosiac mice. These female mice have half their cells expressing Beta-galactosidase and the other half inactive Beta-galactosidase. The active cells would be expressed as blue, the inactive cells red. Additionally, this trait was inheritable to daughter cells.

			This method was used to show that cell populations which contained only blue or red cells could have progenitor cells migrate in. If the progenitor cell had the same colour, then it would be from the same origin. If not, a different progenitor origin. They found that the cells are likely to originate from local epithelium due to local tissue interactions. However, it was also found that lingual epithelium which had the potential for form taste buds were not necessarily from ectodermal or endodermal origins.

	==Glossary==		==Glossary==

Z3332337: /* FGF signalling and genes */

2012-10-05T02:32:23Z

FGF signalling and genes

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	\|-		\|-
	\| <center>[[~~Figure 1 Spry1-2.jpeg~~]]</center>		\| <center>[[Location and Number of CVP]]</center>
	\| <center>[[CVP of WT(top) and DKO(bottom) mice with H&E and SEM.png]]</center>		\| <center>[[CVP of WT(top) and DKO(bottom) mice with H&E and SEM.png]]</center>

Z3330795: /* External Links */

2012-10-05T00:42:27Z

External Links

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	{{External Links}}		{{External Links}}

	1.[http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2012;volume=3;issue=1;spage=23;epage=23;aulast=Manjila]		1.http://www.surgicalneurologyint.com/article.asp?issn=2152-7806;year=2012;volume=3;issue=1;spage=23;epage=23;aulast=Manjila

	2.[http://embryology.med.unsw.edu.au/embryology/index.php?title=2012_Group_Project_4]		2.http://embryology.med.unsw.edu.au/embryology/index.php?title=2012_Group_Project_4

	3.[http://www.webmd.com/oral-health/picture-of-the-tongue]		3.http://www.webmd.com/oral-health/picture-of-the-tongue

	4.[http://www.tutorvista.com/content/biology/biology-iv/nervous-coordination/tongue-structure.php#parts-of-tongue]		4.http://www.tutorvista.com/content/biology/biology-iv/nervous-coordination/tongue-structure.php#parts-of-tongue

	5.[http://www.cf.ac.uk/biosi/staffinfo/jacob/teaching/sensory/taste.html]		5.http://www.cf.ac.uk/biosi/staffinfo/jacob/teaching/sensory/taste.html

	--[[User:Z8600021\|Mark Hill]] 00:19, 5 October 2012 (EST) There should be text with these links.		--[[User:Z8600021\|Mark Hill]] 00:19, 5 October 2012 (EST) There should be text with these links.

Z3330795: /* Adult Tongue and Taste Buds – Structure and Function */

2012-10-05T00:38:56Z

Adult Tongue and Taste Buds – Structure and Function

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	'''Structure'''		'''Structure'''

	The tongue is located on the floor of the oral cavity, It is a muscular structure with sensory ~~units crowning~~. The tongue is divided into an anterior two thirds and a posterior one third. These regions are divided by a V-shaped groove at the back of the tongue (sulcus terminalis). The anterior two thirds of the tongue is covered by stratified squamous epithelium, It contains a roughened surface and has projections called papillae ~~that vary in shape and number~~.		The tongue is located on the floor of the oral cavity, It is a muscular structure with sensory cells found on the surface. The tongue is divided into an anterior two thirds and a posterior one third. These regions are divided by a V-shaped groove at the back of the tongue (sulcus terminalis). The anterior two thirds of the tongue is covered by stratified squamous epithelium, It contains a roughened surface and has projections called papillae.

	[http://www.webmd.com/oral-health/picture-of-the-tongue]		[http://www.webmd.com/oral-health/picture-of-the-tongue]
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	Taste and smell overlap when humans experience flavour, flavour involves an interaction of taste, smell, texture and temperature, where taste is only a portion of this interaction. when the brain interprets a flavour, contribution from other senses has a significant role in identification. In conclusion Taste and Smell in combination with other senses help develop a sensory interpretation called flavour.[http://www.entnet.org/HealthInformation/smellTaste.cfm]		Taste and smell overlap when humans experience flavour, flavour involves an interaction of taste, smell, texture and temperature, where taste is only a portion of this interaction. when the brain interprets a flavour, contribution from other senses has a significant role in identification. In conclusion Taste and Smell in combination with other senses help develop a sensory interpretation called flavour.[http://www.entnet.org/HealthInformation/smellTaste.cfm]
	[[File:Human smelling.jpg\|500px\|centre]]		[[File:Human smelling.jpg\|500px\|centre]]


	== Human Weekly Development - Two Prominent Studies ==		== Human Weekly Development - Two Prominent Studies ==