2010 Lecture 14 - Revision history

Z3283213: /* Cellular origins of the limb */

2010-09-13T11:35:57Z

Cellular origins of the limb

← Older revision		Revision as of 22:35, 13 September 2010
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	[http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=dbio&part=A3941&rendertype=figure&id=A3956 Hox genes and dynamic patterning of the limb]		[http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=dbio&part=A3941&rendertype=figure&id=A3956 Hox genes and dynamic patterning of the limb]

	=Cellular origins of the limb=		==Cellular origins of the limb==

	===Limb cartilage and bone===		===Limb cartilage and bone===

Z3283213: /* Limb Buds */

2010-09-13T07:33:23Z

Limb Buds

← Older revision		Revision as of 18:33, 13 September 2010
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	* Limbs are initially undifferentiated mesenchyme (mesoderm) with an epithelial (ectoderm) covering.		* Limbs are initially undifferentiated mesenchyme (mesoderm) with an epithelial (ectoderm) covering.
	* Blood vessels then begin forming, the largest (marginal vein) is adjacent to tip of the limbbud.		* Blood vessels then begin forming, the largest (marginal vein) is adjacent to tip of the limbbud.
			* Positioning of the limbs is distant from final location

	==Upper and Lower Limb==		==Upper and Lower Limb==

Z3283213 at 07:26, 13 September 2010

2010-09-13T07:26:10Z

← Older revision		Revision as of 18:26, 13 September 2010
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	* familial predisposition female predominance		* familial predisposition female predominance
	* Growth of femoral head, acetabulum and innominate bone are delayed until the femoral head fits firmly into the acetabulum		* Growth of femoral head, acetabulum and innominate bone are delayed until the femoral head fits firmly into the acetabulum

			[http://embryology.med.unsw.edu.au/Notes/skmus72.htm limb abnormalities]

	===Maternal===		===Maternal===

Z3283213 at 07:22, 13 September 2010

2010-09-13T07:22:00Z

← Older revision		Revision as of 18:22, 13 September 2010
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	* familial predisposition female predominance		* familial predisposition female predominance
	* Growth of femoral head, acetabulum and innominate bone are delayed until the femoral head fits firmly into the acetabulum		* Growth of femoral head, acetabulum and innominate bone are delayed until the femoral head fits firmly into the acetabulum


	===Maternal===		===Maternal===
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	===Genetic===		===Genetic===
	[[File:Trisomy21_hand.jpg\|thumb]]		* Trisomy 21 - Downs syndrome [[File:Trisomy21_hand.jpg\|thumb]]
	* Human Gene Mutations - mutation of any of the patterning genes will result in limb abnormalities		* Human Gene Mutations - mutation of any of the patterning genes will result in limb abnormalities
	Type II syndactyly- HoxD13		Type II syndactyly- HoxD13

Z3283213 at 07:20, 13 September 2010

2010-09-13T07:20:11Z

← Older revision		Revision as of 18:20, 13 September 2010
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	==Limb Abnormalities==		==Limb Abnormalities==

	===~~Genetic~~===		===Congenital Hip Dislocation===
	[[File:~~Trisomy21_hand~~.jpg\|thumb]]		[[File:Congenital dislocation hip.jpg\|thumb\|Congenital Hip Dislocation]]
	* ~~Human Gene Mutations - mutation~~ of ~~any~~ of the ~~patterning genes will result in limb abnormalities (Will put Table on Web page mutations and terminology)~~		* Instability: 1:60 at birth; 1:240 at 1 wk: Dislocation untreated; 1:700
	~~Type II syndactyly- HoxD13~~		* congenital instability of hip, later dislocates by muscle pulls or gravity
			* familial predisposition female predominance
			* Growth of femoral head, acetabulum and innominate bone are delayed until the femoral head fits firmly into the acetabulum


	===Maternal===		===Maternal===
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	* short ill-formed upper or lower limbs		* short ill-formed upper or lower limbs
	* hyperthermia		* hyperthermia

			===Genetic===
			[[File:Trisomy21_hand.jpg\|thumb]]
			* Human Gene Mutations - mutation of any of the patterning genes will result in limb abnormalities
			Type II syndactyly- HoxD13

	===Muscle Development===		===Muscle Development===

	Duchenne Muscular Dystrophy		Duchenne Muscular Dystrophy
	* X-linked dystrophy		* X-linked dystrophy
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	* milder form, adult onset		* milder form, adult onset

	~~===Congenital Hip Dislocation===~~
	~~[[File:Congenital dislocation hip.jpg\|thumb\|Congenital Hip Dislocation]]~~
	* Instability: 1:60 at birth; 1:240 at 1 wk: Dislocation untreated; 1:700
	* congenital instability of hip, later dislocates by muscle pulls or gravity
	* familial predisposition female predominance
	* Growth of femoral head, acetabulum and innominate bone are delayed until the femoral head fits firmly into the acetabulum

	==Online Links==		==Online Links==

Z3283213: /* Hand and Footplates */

2010-09-13T07:15:23Z

Hand and Footplates

← Older revision		Revision as of 18:15, 13 September 2010
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	[http://php.med.unsw.edu.au/cellbiology/index.php?title=2009_Lecture_18 Cell Biology - Cell Death Lecture] \| [http://php.med.unsw.edu.au/cellbiology/index.php?title=2009_Lecture_18 Cell Biology - Apoptosis Lecture]		[http://php.med.unsw.edu.au/cellbiology/index.php?title=2009_Lecture_18 Cell Biology - Cell Death Lecture] \| [http://php.med.unsw.edu.au/cellbiology/index.php?title=2009_Lecture_18 Cell Biology - Apoptosis Lecture]

			[http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=mboc4&part=A3245&rendertype=figure&id=A3246 Fluorescent staining of cells undergoing apoptosis in the limb]

	==Limb Rotation==		==Limb Rotation==

Z3283213: /* Limb Muscle and dermis */

2010-09-13T06:59:42Z

Limb Muscle and dermis

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	* Derived from local proliferating mesenchyme derived from the somatic lateral plate mesoderm (somatopleure)		* Derived from local proliferating mesenchyme derived from the somatic lateral plate mesoderm (somatopleure)

	===Limb ~~Muscle~~ and dermis===		===Limb muscle and dermis===
	* Skeletal muscle derived from somites, the hypaxial part of the myotome		* Skeletal muscle derived from somites, the hypaxial part of the myotome
	* Pax3 positive migratory myoblasts invade the limb bud		* Pax3 positive migratory myoblasts invade the limb bud

Z3283213: /* Limb Muscle and dermis */

2010-09-13T06:59:25Z

Limb Muscle and dermis

← Older revision		Revision as of 17:59, 13 September 2010
Line 147:		Line 147:
	* Derived from local proliferating mesenchyme derived from the somatic lateral plate mesoderm (somatopleure)		* Derived from local proliferating mesenchyme derived from the somatic lateral plate mesoderm (somatopleure)

	==Limb Muscle and dermis==		===Limb Muscle and dermis===
	* Skeletal muscle derived from somites, the hypaxial part of the myotome		* Skeletal muscle derived from somites, the hypaxial part of the myotome
	* Pax3 positive migratory myoblasts invade the limb bud		* Pax3 positive migratory myoblasts invade the limb bud

Z3283213: /* Limb cartilage and bone */

2010-09-13T06:59:11Z

Limb cartilage and bone

← Older revision		Revision as of 17:59, 13 September 2010
Line 144:		Line 144:
	=Cellular origins of the limb=		=Cellular origins of the limb=

	==Limb cartilage and bone==		===Limb cartilage and bone===
	* Derived from local proliferating mesenchyme derived from the somatic lateral plate mesoderm (somatopleure)		* Derived from local proliferating mesenchyme derived from the somatic lateral plate mesoderm (somatopleure)

Z3283213: /* Limb cartilage and bone */

2010-09-13T06:58:21Z

Limb cartilage and bone

← Older revision		Revision as of 17:58, 13 September 2010
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	[http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=dbio&part=A3941&rendertype=figure&id=A3956 Hox genes and dynamic patterning of the limb]		[http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=dbio&part=A3941&rendertype=figure&id=A3956 Hox genes and dynamic patterning of the limb]

	~~===Limb cartilage and bone===~~
	* Derived from local proliferating mesenchyme derived from the somatic lateral plate mesoderm (somatopleure)

	=Cellular origins of the limb=		=Cellular origins of the limb=