2009 Lecture 14 - Revision history

Z8600021: Redirected page to Lecture - Limb Development

2014-09-25T07:32:58Z

← Older revision		Revision as of 18:32, 25 September 2014
Line 1:		Line 1:
			#REDIRECT [[Lecture - Limb Development]]
	=Limb Development=		=Limb Development=
	[[File:Appendicular skeleton.jpg\|left]]		[[File:Appendicular skeleton.jpg\|left]]

2009-09-15T07:51:49Z

Hand and Footplates

← Older revision		Revision as of 18:51, 15 September 2009
Line 166:		Line 166:

	==Hand and Footplates==		==Hand and Footplates==
			[[File:BMP syndactyly.jpg\|thumb\|Depletion of BMP Signaling Causes Interdigital Syndactyly]]
	* 5th week- hand and footplates appear at the ends of limb buds and ridges form digital rays		* 5th week- hand and footplates appear at the ends of limb buds and ridges form digital rays
	* Cells between the digital rays are removed by programmed cell death (apoptosis)		* Cells between the digital rays are removed by programmed cell death (apoptosis)

2009-09-15T05:56:36Z

Introduction

← Older revision		Revision as of 16:56, 15 September 2009
Line 10:		Line 10:

	[[:File:Human_Carnegie_stage_1-23.jpg\|Carnegie stage 1-23]]		[[:File:Human_Carnegie_stage_1-23.jpg\|Carnegie stage 1-23]]

			:'''Lectopia Audio''' Lecture Date: 15-09-2009 Lecture Time: 12:00 Venue: BioMed E Speaker: Mark Hill [http://lectopia.elearning.unsw.edu.au/ilectures/ilectures.lasso?ut=153&id=48841 Limb]

	==Lecture Objectives==		==Lecture Objectives==

2009-09-15T01:58:10Z

Limb Identity

← Older revision		Revision as of 12:58, 15 September 2009
Line 67:		Line 67:
	* Tbx2 and Tbx3 are expressed in both limbs.		* Tbx2 and Tbx3 are expressed in both limbs.

	'''Related Research''' - [http://www.ncbi.nlm.nih.gov/pubmed/12490567?dopt=Abstract PMID: 12490567] \| [http://dev.biologists.org/cgi/content/figsonly/130/3/623 Development 2003 Figures] \| [http://dev.biologists.org/cgi/content/full/130/3/623/FIG1 Scanning electron micrographs of E9 Limb bud wild-type and Tbx5del/del] \| [http://www.ncbi.nlm.nih.gov/pubmed/12736217?dopt=Abstract PMID: 12736217] \| [http://dev.biologists.org/cgi/content/figsonly/130/12/2741 Development 2003 Figures]		'''Related Research''' - [http://www.ncbi.nlm.nih.gov/pubmed/12490567?dopt=Abstract PMID: 12490567] \| [http://dev.biologists.org/cgi/content/figsonly/130/3/623 Development 2003 Figures] \| [http://dev.biologists.org/cgi/content/full/130/3/623/FIG1 Scanning electron micrographs of E9 Limb bud wild-type and Tbx5del/del] [http://dev.biologists.org/cgi/content/full/130/3/623/FIG7 A model for early stages of limb bud growth] \| [http://www.ncbi.nlm.nih.gov/pubmed/12736217?dopt=Abstract PMID: 12736217] \| [http://dev.biologists.org/cgi/content/figsonly/130/12/2741 Development 2003 Figures]

	===Body Axes===		===Body Axes===

2009-09-15T01:55:35Z

Limb Rotation

← Older revision		Revision as of 12:55, 15 September 2009
Line 176:		Line 176:

	==Limb Rotation==		==Limb Rotation==
			[[File:Stage20-23 limbs a.jpg\|thumb]]
	* 8th week limbs rotate in different directions (Humans Stage 20-23)		* 8th week limbs rotate in different directions (Humans Stage 20-23)
	* thumb and toe rostral		* thumb and toe rostral

2009-09-15T01:54:42Z

Limb Innervation

← Older revision		Revision as of 12:54, 15 September 2009
Line 184:		Line 184:
	==Limb Innervation==		==Limb Innervation==
	[[File:Gray0807.gif\|thumb\|brachial plexus]]		[[File:Gray0807.gif\|thumb\|brachial plexus]]
			[[File:Dermatomes.png\|thumb\|Adult Dermatomes]]
	* spinal cord segmental nerves form a plexus adjacent to each limb		* spinal cord segmental nerves form a plexus adjacent to each limb
	* Brachial (upper) lumbar (lower)		* Brachial (upper) lumbar (lower)

2009-09-15T01:51:39Z

Limb Innervation

← Older revision		Revision as of 12:51, 15 September 2009
Line 183:		Line 183:

	==Limb Innervation==		==Limb Innervation==
			[[File:Gray0807.gif\|thumb\|brachial plexus]]
	* spinal cord segmental nerves form a plexus adjacent to each limb		* spinal cord segmental nerves form a plexus adjacent to each limb
	* Brachial (upper) lumbar (lower)		* Brachial (upper) lumbar (lower)

2009-09-15T01:47:24Z

Limb Initiation

← Older revision		Revision as of 12:47, 15 September 2009
Line 56:		Line 56:
	* FGF can respecify Hox gene expression (Hox9- limb position)		* FGF can respecify Hox gene expression (Hox9- limb position)
	* Hox could then activate FGF expression		* Hox could then activate FGF expression

			Note that during the embryonic period there is a rostrocaudal (anterior posterior) timing difference between the upper and lower limb development
			* this means that developmental changes in the upper limb can precede similar changes in the lower limb (2-5 day difference in timing)

	===Limb Identity===		===Limb Identity===

2009-09-15T01:44:57Z

Hand and Footplates

← Older revision		Revision as of 12:44, 15 September 2009
Line 163:		Line 163:
	* 5th week- hand and footplates appear at the ends of limb buds and ridges form digital rays		* 5th week- hand and footplates appear at the ends of limb buds and ridges form digital rays
	* Cells between the digital rays are removed by programmed cell death (apoptosis)		* Cells between the digital rays are removed by programmed cell death (apoptosis)
			* 3-5 day difference between hand and foot development

2009-09-15T01:43:59Z

Hand and Footplates

← Older revision		Revision as of 12:43, 15 September 2009
Line 163:		Line 163:
	* 5th week- hand and footplates appear at the ends of limb buds and ridges form digital rays		* 5th week- hand and footplates appear at the ends of limb buds and ridges form digital rays
	* Cells between the digital rays are removed by programmed cell death (apoptosis)		* Cells between the digital rays are removed by programmed cell death (apoptosis)


			[http://www.med.unc.edu/embryo_images/unit-mslimb/mslimb_htms/mslimb024.htm hand growth]

	===Apoptosis===		===Apoptosis===