User talk:Z3417753

From Embryology






  • Currently there are no effective treatments for children suffering with advanced anatomical disorders of the trachea.
  • An example of such a disorder is congenital tracheal stenosis, characterised by the presence of complete tracheal rings and stenosis of the larger airways.[1]
  • Children suffering with such congenital abnormalities often require constant hospitalisation with slide tracheoplasty being the preferred choice of treatment, however it is very common for patients to develop recurrent stenoses.[2]
  • This is often a result of stent erosion[3], ultimately leading to death or the ability of the trachea to undergo somatic growth.[1]
  • Due to the severity of these conditions, they are considered fatal and once detected prenatally, the pregnancies are often terminated.[4]
  • In the past few years, there has been an increased use of tissue-engineered structures made from stem cells within clinical settings.
  • Benefits of stem cell-based tissue engineering procedures arise from the notion that remodeling of the native stroma would result in a lack of immunosuppression due to the similarity of the local tissue.
  • A case was reported where a successful stem cell-based tracheal replacement procedure was performed on a 26-year-old patient with end-stage airway disease.[5]
  • Whilst stem cell-based tracheal grafts have been successful with positive short-term outcomes, little evidence exists regarding the long-term effects of the grafts, specifically on children.
  • This study reports a 2-year follow-up of the first paediatric stem cell-based tracheal replacement, with the notion in mind that ideal results following the procedure are:
  • Normal airway and lung function
    Appropriate somatic growth
    Increased quality of life
    Elimination of the need for continuous hospitalisation and the constant advent of surgical procedures.

  1. 1.0 1.1 <pubmed>22381446</pubmed>
  2. <pubmed>15573072</pubmed>
  3. <pubmed>11053808</pubmed>
  4. <pubmed>21860060</pubmed>
  5. <pubmed>19022496</pubmed>