User:Z5019282

From Embryology
Student Information (expand to read)  
Individual Assessments
Mark Hill.jpg

Please leave this template on top of your student page as I will add your assessment items here.

Beginning your online work - Working Online in this course

  1. Make your own page.
    1. Log-in to the embryology website using your student ID and Zpass.
    2. Click your student number (shown in red at the top right of the screen following log-in)
    3. Create page using the tab at the top of the page, and save.
  2. Add the following to the top of your page exactly as shown - {{ANAT2341Student2016}}
  3. How would you identify your Type in a group and add to your page.
  4. What was the most interesting thing you learnt in the fertilisation lecture?


If you have done the above correctly your ZID should be blue and not red on this page link - ANAT2341 2016 Students.


Here is the example page I made in Lab 1 Student Page. With a few more explanatory notes.

Click here to email Dr Mark Hill

Editing Links: Editing Basics | Images | Tables | Referencing | Journal Searches | Copyright | Font Colours | Virtual Slide Permalink | My Preferences | One Page Wiki Card | Printing | Movies | Language Translation | Student Movies | Using OpenOffice | Internet Browsers | Moodle | Navigation/Contribution | Term Link | Short URLs | 2018 Test Student
Lab 1 Assessment - Researching a Topic
In the lab I showed you how to find the PubMed reference database and search it using a topic word. Lab 1 assessment will be for you to use this to find a research reference on "fertilization" and write a brief summary of the main finding of the paper.
  1. Add a new Sub-heading "Lab 1 Assessment" (without the quotes).
  2. Search the database for a reference on "fertilisation" published in the last 5 years.
    1. It must be a research article not a Review.
    2. The full paper must be available online, not just the abstract.
  3. Add a link to this reference using its PMID using this code <pubmed>XXXXX</pubmed> replacing the Xs with just the PMID number (no text).
  4. Under the reference write a short summary of the papers main findings.
    1. Only 1-2 paragraphs.
    2. Must not be a copy of the paper abstract.
  5. Save and you are done.

PubMed logo.gif

Lab 2 Assessment - Uploading an Image
  1. Upload a research image using the guide information below. The image uploaded for your individual assessment can relate to your project or from fertilisation to week 3 of development (upload only a single image).
  2. Add that image to your own individual page (see Images) including an image title and its reference link.
  3. No two students should upload the same image, check new images before you upload.
  4. No student can delete an image once uploaded, please contact me by email with the image address and I will delete (with no penalty, just glad to help out).


2016 Group Project Topic - Signaling in Development

OK you are now in a group

  1. Go to the blank group page and add a topic that interests you along with your student signature.
  2. No two groups can do the same topic, but at this stage the final topic has not yet been decided (next week).

Initially the topic can be as specific or as broad as you want.


Chicken embryo E-cad and P-cad gastrulation.png

Chicken embryo E-cad and P-cad gastrulation[1]

References

  1. <pubmed>27097030</pubmed>
Lab 4 Assessment - GIT Quiz

ANAT2341 Quiz Example | Category:Quiz | ANAT2341 Student 2015 Quiz Questions |

Design 4 quiz questions based upon gastrointestinal tract. Add the quiz to your own page under Lab 4 assessment and provide a sub-sub-heading on the topic of the quiz.

An example is shown below (open this page in view code or edit mode). Note that it is not just how you ask the question, but also how you explain the correct answer.

Lab 5 Assessment - Course Review
Complete the course review questionnaire and add the fact you have completed to your student page.
Lab 6 Assessment - Cleft Lip and Palate
  1. Identify a known genetic mutation that is associated with cleft lip or palate.
  2. Identify a recent research article on this gene.
  3. How does this mutation affect developmental signalling in normal development.
Lab 7 Assessment - Muscular Dystrophy
  1. What is/are the dystrophin mutation(s)?
  2. What is the function of dystrophin?
  3. What other tissues/organs are affected by this disorder?
  4. What therapies exist for DMD?
  5. What animal models are available for muscular dystrophy?
Lab 8 Assessment - Quiz
A brief quiz was held in the practical class on urogenital development.
Lab 9 Assessment - Peer Assessment
  • This will form part of your individual assessment for the course.
  • Each student should now look at each of the other Group projects in the class.
  • Next prepare a critical assessment (should include both positive and negative issues) of each project using the project group assessment criteria.
  • This assessment should be pasted without signature on the top of the specific project's discussion page. (minimum length 3-5 paragraphs/project)
  • This critical assessment should also be pasted on your own student page.
  • Each student should therefore have 5 separate reports pasted on their own page for this assessment item.
  • Length, quality and accuracy of your reports will be part of the overall mark for this assessment.
    • there will be a greater loading on this than simple question assessments.
Lab 10 Assessment - Stem Cells
As part of the assessment for this course, you will give a 15 minutes journal club presentation in Lab 10. For this you will in your current student group discuss a recent (published after 2011) original research article (not a review!) on stem cell biology or technology.
Lab 10 - Stem Cell Presentations 2016
Group Mark Assessor General Comments

Group 1: 15/20

Group 2: 19/20

Group 3: 20/20

Group 4: 19/20

Group 5: 16/20

Group 6: 16/20

The students put great effort in their presentation and we heard a nice variety of studies in stem cell biology and regenerative medicine today. The interaction after the presentation was great.

As general feedback I would like to advise students to:

  • Never discuss M&M as a separate section in journal clubs. I gave this advice prior to the lab, but still most groups did talk through the M&M section.
  • Do not use your slides as cheat sheets, avoid text on slides, know what messages you need to get across, use images to illustrate these
  • Engage with your slides. Talk through them. Point at panels. Gauge your audience’s understanding by making eye contact with them
  • Avoid using abbreviations. Most people do not readily understand these and will lose track
Lab 11 Assessment - Heart Development
Read the following recent review article on heart repair and from the reference list identify a cited research article and write a brief summary of the paper's main findings. Then describe how the original research result was used in the review article.

<pubmed>26932668</pubmed>Development

ANAT2341Lectures - Textbook chapters  
Lecture (Timetable) Textbook - The Developing Human Textbook - Larsen's Human Embryology
Embryology Introduction Introduction to the Developing Human
Fertilization First Week of Human Development Gametogenesis, Fertilization, and First Week
Week 1 and 2 Second Week of Human Development Second Week: Becoming Bilaminar and Fully Implanting
Week 3 Third Week of Human Development Third Week: Becoming Trilaminar and Establishing Body Axes
Mesoderm Fourth to Eighth Weeks of Human Development Fourth Week: Forming the Embryo
Ectoderm Nervous System Development of the Central Nervous System
Early Vascular Cardiovascular System Development of the Vasculature
Placenta Placenta and Fetal Membranes Development of the Vasculature
Endoderm - GIT Alimentary System Development of the Gastrointestinal Tract
Respiratory Respiratory System Development of the Respiratory System and Body Cavities
Head Pharyngeal Apparatus, Face, and Neck Development of the Pharyngeal Apparatus and Face
Neural Crest Nervous System Development of the Peripheral Nervous System
Musculoskeletal Muscular System Development of the Musculoskeletal System
Limb Development of Limbs Development of the Limbs
Renal Urogenital System Development of the Urinary System
Genital Urogenital System Development of the Urinary System
Stem Cells
Integumentary Integumentary System Development of the Skin and Its Derivatives
Endocrine Covered through various chapters (see also alternate text), read head and neck, neural crest and renal chapters.
Endocrinology Textbook - Chapter Titles  
Nussey S. and Whitehead S. Endocrinology: An Integrated Approach (2001) Oxford: BIOS Scientific Publishers; ISBN-10: 1-85996-252-1.

Full Table of Contents

Heart Cardiovascular System Development of the Heart
Sensory Development of Eyes and Ears Development of the Eyes
Fetal Fetal Period Fetal Development and the Fetus as Patient
Birth and Revision
Additional Textbook Content - The following concepts also form part of the theory material covered throughout the course.
  1. Principles and Mechanisms of Morphogenesis and Dysmorphogenesis
  2. Common Signaling Pathways Used During Development
  3. Human Birth Defect
ANAT2341 Course Timetable  
Week (Mon) Lecture 1 (Mon 1-2pm) Lecture 2 (Tue 3-4pm) Practical (Fri 1-3pm)
Week 2 (1 Aug) Introduction Fertilization Lab 1
Week 3 (8 Aug) Week 1 and 2 Week 3 Lab 2
Week 4 (15 Aug) Mesoderm Ectoderm Lab 3
Week 5 (22 Aug) Early Vascular Placenta Lab 4
Week 6 (29 Aug) Gastrointestinal Respiratory Lab 5
Week 7 (5 Sep) Head Neural Crest Lab 6
Week 8 (12 Sep) Musculoskeletal Limb Development Lab 7
Week 9 (19 Sep) Renal Genital Lab 8
Mid-semester break
Week 10 (3 Oct) Public Holiday Stem Cells Lab 9
Week 11 (10 Oct) Integumentary Endocrine Lab 10
Week 12 (17 Oct) Heart Sensory Lab 11
Week 13 (24 Oct) Fetal Birth and Revision Lab 12

ANAT2341 2016: Moodle page | ECHO360 | Textbooks | Students 2016 | Projects 2016


Lab Attendance

Z5019282 (talk) 14:35, 5 August 2016 (AEST)

Z5019282 (talk) 14:41, 12 August 2016 (AEST)

Z5019282 (talk) 14:40, 26 August 2016 (AEST)

Z5019282 (talk) 13:20, 9 September 2016 (AEST)

Z5019282 (talk) 13:13, 16 September 2016 (AEST)

Lab 1 Assessment

<pubmed>27413417</pubmed>

Albumins are a type of water soluble protein primarily found in blood which also have a purpose in inducing the artificial capacitation of sperm. Capacitation is a process of the maturation of sperm occuring in the female reproductive tract in which the acrosomal head is distabilized to allow a greater degree of binding with sperm and oocyte. Other cellular changes such as the formation of ROS and protein phosphorylation of Tyrosine residues also occurs. This paper aims to measure the extent of capacitation of sperm via different serums through tests such as ROS Level Measurement, Sperm Mmotion Analysis, a Hemizona Assay, Acrosome Reaction Evaluation, Western Blot Analysis of Tyrosine Phosphorylation and Sperm DNA Damage Assessment. These values obtained via each test were then subjected to statistical analysis via Wilcoxon signed-rank test which determines whether population means differ between samples. 30 samples of semen were obtained from male specimens, each sample split up into 4 portions and subsequently cultured by 4 different preparation media; HTS, HTP, QFS and QTP respectively which used differing levels of SSS (Serum Substitute Supplement) and SPS (Quinns Advantage Serum Protein Substitute) which are both known spermatozoa capacitating agents. It was found that the Serum Supplements induced semen capacitation at varying levels, primarily influenced by ROS levels in preparation media and secondarily by the combination of Serum Supplements and Media used.

Mark Hill 18 August 2016 - You have added the citation correctly and written a good brief summary of the article findings. There is quite a bit of current research looking at what effects success rates in these clinical techniques. I would point out that this is not a high quality journal 4.49 (good 20 to 50), try and look at these journals. Assessment 5/5

Lab 2 Assessment

Induction of Ovulation in Mouse Ovaries and its relation to tumor induction through labelling with mCherry expressing Lentivirus.jpg


Mark Hill 29 August 2016 - All information Reference, Copyright and Student Image template included with the file but wrong PMID for reference and some formatting issues. The image should also be referenced here with a legend as shown below.

and referenced on your page here.

Assessment 3/5

Induction of Ovulation in Mouse Ovaries and its relation to tumor induction through labelling with mCherry expressing Lentivirus.jpg

Induction of Ovulation in Mouse Ovaries and its relation to tumor induction through labelling with mCherry expressing Lentivirus[1]


  1. <pubmed>25135607</pubmed>


Lab 4 Assessment

1

The incidence of Gastroschisis is:

1.66/10,000
1.66/1,000
1.66/100
1.66/10

2

There are three distinct portions of the GIT by the end of week 4.

TRUE.
FALSE.

3

The Gastrointestinal Tract does not function until after birth.

TRUE.
FALSE.

4

Intestinal Aganglionosis is a condition where:

There are bands crossing the duodenum causing obstruction.
There is improper closure and absorption of the vitelline duct during development
There is an absence of the ENS within the GIT.
There is a narrowing of the lumen of the GIT.


Mark Hill 13 October 2016 - These seem quiz questions that could have been better designed to test developmental knowledge. Question 1 could be guessed and is just testing how accurately they remember the statistic, would have been better to use different numbers. Question 4 acronyms should not be used in quizzes, particularly if not spelt out in the question. Assessment 4.5/5

Lab Work

Lab 7

Estimated prevalence of Duchenne is 1 in 7250 for males aged 5-24. Non-hispanic blacks had a lower prevalence of Duchenne Muscular dystrophy as compared to Hispanics and Nnon-Hisapnic whites. http://www.cdc.gov/ncbddd/musculardystrophy/data.html

DMD is diagnosed through DNA tests searching for deletions, duplications and point mutations, a muscular biopsy is more conclusive than the DNA testing itself. In DMD, there is a lack of the protein dystrophin which leads to muscle deterioration and breakdown. An animal model used is the MDX mouse which has missing functional dystrophin protein in the muscle Dystrophin connects the cytoskeleton of the muscle fibre to extracellular matrix through the cell membrane.

Mark Hill 13 October 2016 - Good brief answers, There is no referencing of your answers. Assessment 4/5


Mark Hill 13 October 2016 - Lab 6 - Cleft lip/ palate assessment?

Lab 9

Peer Assessment of Group Presentations: Assessment not completed You could have added some peer assessment here, even if submitted late. Had you added peer assessment to the discussion pages and not your own page? 0/10

Lab 10 - Stem Cell Presentations 2016
Group Mark Assessor General Comments

Group 1: 15/20

Group 2: 19/20

Group 3: 20/20

Group 4: 19/20

Group 5: 16/20

Group 6: 16/20

The students put great effort in their presentation and we heard a nice variety of studies in stem cell biology and regenerative medicine today. The interaction after the presentation was great.

As general feedback I would like to advise students to:

  • Never discuss M&M as a separate section in journal clubs. I gave this advice prior to the lab, but still most groups did talk through the M&M section.
  • Do not use your slides as cheat sheets, avoid text on slides, know what messages you need to get across, use images to illustrate these
  • Engage with your slides. Talk through them. Point at panels. Gauge your audience’s understanding by making eye contact with them
  • Avoid using abbreviations. Most people do not readily understand these and will lose track