|Student Information (expand to read)|
Please leave this template on top of your student page as I will add your assessment items here.
Beginning your online work - Working Online in this course
|Lab 1 Assessment - Researching a Topic|
|In the lab I showed you how to find the PubMed reference database and search it using a topic word. Lab 1 assessment will be for you to use this to find a research reference on "fertilization" and write a brief summary of the main finding of the paper.
|Lab 2 Assessment - Uploading an Image|
OK you are now in a group
Initially the topic can be as specific or as broad as you want.
Chicken embryo E-cad and P-cad gastrulation
|Lab 4 Assessment - GIT Quiz|
Design 4 quiz questions based upon gastrointestinal tract. Add the quiz to your own page under Lab 4 assessment and provide a sub-sub-heading on the topic of the quiz.
An example is shown below (open this page in view code or edit mode). Note that it is not just how you ask the question, but also how you explain the correct answer.
|Lab 5 Assessment - Course Review|
|Complete the course review questionnaire and add the fact you have completed to your student page.|
|Lab 6 Assessment - Cleft Lip and Palate|
|Lab 7 Assessment - Muscular Dystrophy|
|Lab 8 Assessment - Quiz|
|A brief quiz was held in the practical class on urogenital development.|
|Lab 9 Assessment - Peer Assessment|
|Lab 10 Assessment - Stem Cells|
|As part of the assessment for this course, you will give a 15 minutes journal club presentation in Lab 10. For this you will in your current student group discuss a recent (published after 2011) original research article (not a review!) on stem cell biology or technology.
|Lab 11 Assessment - Heart Development|
|Read the following recent review article on heart repair and from the reference list identify a cited research article and write a brief summary of the paper's main findings. Then describe how the original research result was used in the review article.
- 1 Lab Attendance
- 2 Useful Links
- 3 Individual Assessment
- 4 References
absent due to illness
|Mark Hill 17 October 2016 - There are a number of individual assessment items that have not been completed here.|
Type in a group? A mix of everything: co-ordinator, team worker, resource-investigator, implementer, shaper, monitor-evaluator!
The most interesting thing I learnt in the fertilisation lecture? That the oocyte doesn't complete meiosis II until it's fertilised! didn't know that before, wacky as.
Lab 1 Assessment
In this article by Ohto et al. (2016), the group report on findings from their study into the crystal structures of two key proteins involved in sperm–oocyte fusion in human fertilization. IZUMO1 is a sperm transmembrane protein and JUNO is its corresponding receptor found on the surface of the oocyte. X-ray crystallography was used to elucidate the molecular mechanisms behind their interaction and formation of the IZUMO1–JUNO complex. The study found IZUMO1 to bear an elongated rod-shaped structure 90 Å in length, consisting of an N-terminal alpha-helical bundle IZUMO domain and a C-terminal immunoglobulin-like domain, connected by an intervening β-hairpin region via disulfide bonds. This central β-hairpin region was shown to provide the main platform for specific binding to the surface behind the ligand binding pocket on JUNO, which exhibits a single globular fold comprised of eight α-helices and four β-strands, stabilized by eight disulfide bonds. Hydrophobic and van der Waals interactions are the main contributing forces to the binding along with six hydrogen bonds. Subsequent cell–oocyte binding assays were successfully conducted using mouse cells expressing either wild-type or mutant Izumo1 proteins to confirm the functional relevance of the IZUMO1–JUNO interface in sperm–oocyte attachment. Overall the study provided a major development in determining the mechanisms of sperm-oocyte recognition and the IZUMO1–JUNO as an essential part of fertilization. The findings have potential applications in contributing to the development of new therapeutics relating to fertility, such as contraceptive agents.
|Mark Hill September 2016 - This is a relevant article and summary for fertilisation topic. Added after the submission date.||Assessment 4/5|
Lab 2 Assessment
Primitive Streak Cell Migration In Chick Embryo 
|Mark Hill September 2016 - Image added with correct reference, copyright and student template.||Assessment 5/5|
Lab 3 Assessment
|Mark Hill 31 August 2016 - Lab 3 Assessment Quiz - Mesoderm and Ectoderm development.||Assessment 5/5|
Lab 4 Assessment
Gastrointestinal Tract Quiz.
Lab 5 Assessment
Course Feedback Questionnaire - Absent due to illness therefore could not complete in-class questionnaire
Lab 6 Assessment
Identify a known genetic mutation that is associated with cleft lip or palate: Mutation in X-linked TBX22 gene (T-box 22).
Identify a recent research article on this gene: 
How does this mutation affect developmental signaling in normal development:
Lab 7 Assessment
Duchenne Muscular Dystrophy
- Populations Affected:
- Current and Emerging Therapeutics:
- mutations in the protein Dystrophin
- only apparent postnatally once muscles in use
- Tissues Affected:
- skeletal muscle
- prenatal genetic diagnosis
- muscle biopsy
- Animal Models for DMD:
- MDX Mouse Model
|Mark Hill 11 October 2016 - You have answered most of the questions, some of which are too general, and do not included any citations for your answers.||Assessment 3/5|
Lab 8 Assessment
|Mark Hill 27 October 2016||Assessment 4.5/8|
Lab 9 Assessment
Peer Assessment of Group Presentations: Assessment not completed
You could have added some peer assessment here, even if submitted late. 0/10
Lab 10 Assessment
|Lab 10 - Stem Cell Presentations 2016|
|Group Mark||Assessor General Comments|
Group 1: 15/20
Group 2: 19/20
Group 3: 20/20
Group 4: 19/20
Group 5: 16/20
Group 6: 16/20
|The students put great effort in their presentation and we heard a nice variety of studies in stem cell biology and regenerative medicine today. The interaction after the presentation was great.
As general feedback I would like to advise students to:
Lab 11 Assessment
Cited research article on heart repair from review by Foglia & Poss (2016): Summary of findings: How the original research result was used in the Foglia & Poss review: