User:Z5017002

From Embryology
Student Information (expand to read)  
Individual Assessments
Mark Hill.jpg

Please leave this template on top of your student page as I will add your assessment items here.

Beginning your online work - Working Online in this course

  1. Make your own page.
    1. Log-in to the embryology website using your student ID and Zpass.
    2. Click your student number (shown in red at the top right of the screen following log-in)
    3. Create page using the tab at the top of the page, and save.
  2. Add the following to the top of your page exactly as shown - {{ANAT2341Student2016}}
  3. How would you identify your Type in a group and add to your page.
  4. What was the most interesting thing you learnt in the fertilisation lecture?


If you have done the above correctly your ZID should be blue and not red on this page link - ANAT2341 2016 Students.


Here is the example page I made in Lab 1 Student Page. With a few more explanatory notes.

Click here to email Dr Mark Hill

Editing Links: Editing Basics | Images | Tables | Referencing | Journal Searches | Copyright | Font Colours | Virtual Slide Permalink | My Preferences | One Page Wiki Card | Printing | Movies | Language Translation | Student Movies | Using OpenOffice | Internet Browsers | Moodle | Navigation/Contribution | Term Link | Short URLs | 2018 Test Student
Lab 1 Assessment - Researching a Topic
In the lab I showed you how to find the PubMed reference database and search it using a topic word. Lab 1 assessment will be for you to use this to find a research reference on "fertilization" and write a brief summary of the main finding of the paper.
  1. Add a new Sub-heading "Lab 1 Assessment" (without the quotes).
  2. Search the database for a reference on "fertilisation" published in the last 5 years.
    1. It must be a research article not a Review.
    2. The full paper must be available online, not just the abstract.
  3. Add a link to this reference using its PMID using this code <pubmed>XXXXX</pubmed> replacing the Xs with just the PMID number (no text).
  4. Under the reference write a short summary of the papers main findings.
    1. Only 1-2 paragraphs.
    2. Must not be a copy of the paper abstract.
  5. Save and you are done.

PubMed logo.gif

Lab 2 Assessment - Uploading an Image
  1. Upload a research image using the guide information below. The image uploaded for your individual assessment can relate to your project or from fertilisation to week 3 of development (upload only a single image).
  2. Add that image to your own individual page (see Images) including an image title and its reference link.
  3. No two students should upload the same image, check new images before you upload.
  4. No student can delete an image once uploaded, please contact me by email with the image address and I will delete (with no penalty, just glad to help out).


2016 Group Project Topic - Signaling in Development

OK you are now in a group

  1. Go to the blank group page and add a topic that interests you along with your student signature.
  2. No two groups can do the same topic, but at this stage the final topic has not yet been decided (next week).

Initially the topic can be as specific or as broad as you want.


Chicken embryo E-cad and P-cad gastrulation.png

Chicken embryo E-cad and P-cad gastrulation[1]

References

  1. <pubmed>27097030</pubmed>
Lab 4 Assessment - GIT Quiz

ANAT2341 Quiz Example | Category:Quiz | ANAT2341 Student 2015 Quiz Questions |

Design 4 quiz questions based upon gastrointestinal tract. Add the quiz to your own page under Lab 4 assessment and provide a sub-sub-heading on the topic of the quiz.

An example is shown below (open this page in view code or edit mode). Note that it is not just how you ask the question, but also how you explain the correct answer.

Lab 5 Assessment - Course Review
Complete the course review questionnaire and add the fact you have completed to your student page.
Lab 6 Assessment - Cleft Lip and Palate
  1. Identify a known genetic mutation that is associated with cleft lip or palate.
  2. Identify a recent research article on this gene.
  3. How does this mutation affect developmental signalling in normal development.
Lab 7 Assessment - Muscular Dystrophy
  1. What is/are the dystrophin mutation(s)?
  2. What is the function of dystrophin?
  3. What other tissues/organs are affected by this disorder?
  4. What therapies exist for DMD?
  5. What animal models are available for muscular dystrophy?
Lab 8 Assessment - Quiz
A brief quiz was held in the practical class on urogenital development.
Lab 9 Assessment - Peer Assessment
  • This will form part of your individual assessment for the course.
  • Each student should now look at each of the other Group projects in the class.
  • Next prepare a critical assessment (should include both positive and negative issues) of each project using the project group assessment criteria.
  • This assessment should be pasted without signature on the top of the specific project's discussion page. (minimum length 3-5 paragraphs/project)
  • This critical assessment should also be pasted on your own student page.
  • Each student should therefore have 5 separate reports pasted on their own page for this assessment item.
  • Length, quality and accuracy of your reports will be part of the overall mark for this assessment.
    • there will be a greater loading on this than simple question assessments.
Lab 10 Assessment - Stem Cells
As part of the assessment for this course, you will give a 15 minutes journal club presentation in Lab 10. For this you will in your current student group discuss a recent (published after 2011) original research article (not a review!) on stem cell biology or technology.
Lab 10 - Stem Cell Presentations 2016
Group Mark Assessor General Comments

Group 1: 15/20

Group 2: 19/20

Group 3: 20/20

Group 4: 19/20

Group 5: 16/20

Group 6: 16/20

The students put great effort in their presentation and we heard a nice variety of studies in stem cell biology and regenerative medicine today. The interaction after the presentation was great.

As general feedback I would like to advise students to:

  • Never discuss M&M as a separate section in journal clubs. I gave this advice prior to the lab, but still most groups did talk through the M&M section.
  • Do not use your slides as cheat sheets, avoid text on slides, know what messages you need to get across, use images to illustrate these
  • Engage with your slides. Talk through them. Point at panels. Gauge your audience’s understanding by making eye contact with them
  • Avoid using abbreviations. Most people do not readily understand these and will lose track
Lab 11 Assessment - Heart Development
Read the following recent review article on heart repair and from the reference list identify a cited research article and write a brief summary of the paper's main findings. Then describe how the original research result was used in the review article.

<pubmed>26932668</pubmed>Development

ANAT2341Lectures - Textbook chapters  
Lecture (Timetable) Textbook - The Developing Human Textbook - Larsen's Human Embryology
Embryology Introduction Introduction to the Developing Human
Fertilization First Week of Human Development Gametogenesis, Fertilization, and First Week
Week 1 and 2 Second Week of Human Development Second Week: Becoming Bilaminar and Fully Implanting
Week 3 Third Week of Human Development Third Week: Becoming Trilaminar and Establishing Body Axes
Mesoderm Fourth to Eighth Weeks of Human Development Fourth Week: Forming the Embryo
Ectoderm Nervous System Development of the Central Nervous System
Early Vascular Cardiovascular System Development of the Vasculature
Placenta Placenta and Fetal Membranes Development of the Vasculature
Endoderm - GIT Alimentary System Development of the Gastrointestinal Tract
Respiratory Respiratory System Development of the Respiratory System and Body Cavities
Head Pharyngeal Apparatus, Face, and Neck Development of the Pharyngeal Apparatus and Face
Neural Crest Nervous System Development of the Peripheral Nervous System
Musculoskeletal Muscular System Development of the Musculoskeletal System
Limb Development of Limbs Development of the Limbs
Renal Urogenital System Development of the Urinary System
Genital Urogenital System Development of the Urinary System
Stem Cells
Integumentary Integumentary System Development of the Skin and Its Derivatives
Endocrine Covered through various chapters (see also alternate text), read head and neck, neural crest and renal chapters.
Endocrinology Textbook - Chapter Titles  
Nussey S. and Whitehead S. Endocrinology: An Integrated Approach (2001) Oxford: BIOS Scientific Publishers; ISBN-10: 1-85996-252-1.

Full Table of Contents

Heart Cardiovascular System Development of the Heart
Sensory Development of Eyes and Ears Development of the Eyes
Fetal Fetal Period Fetal Development and the Fetus as Patient
Birth and Revision
Additional Textbook Content - The following concepts also form part of the theory material covered throughout the course.
  1. Principles and Mechanisms of Morphogenesis and Dysmorphogenesis
  2. Common Signaling Pathways Used During Development
  3. Human Birth Defect
ANAT2341 Course Timetable  
Week (Mon) Lecture 1 (Mon 1-2pm) Lecture 2 (Tue 3-4pm) Practical (Fri 1-3pm)
Week 2 (1 Aug) Introduction Fertilization Lab 1
Week 3 (8 Aug) Week 1 and 2 Week 3 Lab 2
Week 4 (15 Aug) Mesoderm Ectoderm Lab 3
Week 5 (22 Aug) Early Vascular Placenta Lab 4
Week 6 (29 Aug) Gastrointestinal Respiratory Lab 5
Week 7 (5 Sep) Head Neural Crest Lab 6
Week 8 (12 Sep) Musculoskeletal Limb Development Lab 7
Week 9 (19 Sep) Renal Genital Lab 8
Mid-semester break
Week 10 (3 Oct) Public Holiday Stem Cells Lab 9
Week 11 (10 Oct) Integumentary Endocrine Lab 10
Week 12 (17 Oct) Heart Sensory Lab 11
Week 13 (24 Oct) Fetal Birth and Revision Lab 12

ANAT2341 2016: Moodle page | ECHO360 | Textbooks | Students 2016 | Projects 2016

Lab Attendance

Lab 1

Z5017002 (talk) 14:57, 5 August 2016 (AEST)

Lab 2

Z5017002 (talk) 14:07, 12 August 2016 (AEST)

Lab 3

Z5017002 (talk) 14:01, 19 August 2016 (AEST)

Lab 4

Z5017002 (talk) 14:09, 26 August 2016 (AEST)

Lab 5

absent due to illness

Lab 6

Z5017002 (talk) 14:12, 9 September 2016 (AEST)

Lab 7

Z5017002 (talk) 14:05, 16 September 2016 (AEST)

Lab 8

Lab 9

Lab 10

Lab 11

Lab 12

Z5017002 (talk) 14:02, 21 October 2016 (AEDT)

Mark Hill 17 October 2016 - There are a number of individual assessment items that have not been completed here.

Useful Links

External Link

[1]

Internal Link

https://embryology.med.unsw.edu.au/embryology/index.php/2011_Lab_1

ANAT2341 Lab 1

Student Page

Individual Assessment

Type in a group? A mix of everything: co-ordinator, team worker, resource-investigator, implementer, shaper, monitor-evaluator!

The most interesting thing I learnt in the fertilisation lecture? That the oocyte doesn't complete meiosis II until it's fertilised! didn't know that before, wacky as.

Lab 1 Assessment

Article:

<pubmed>27309808</pubmed>

In this article by Ohto et al. (2016), the group report on findings from their study into the crystal structures of two key proteins involved in sperm–oocyte fusion in human fertilization. IZUMO1 is a sperm transmembrane protein and JUNO is its corresponding receptor found on the surface of the oocyte. X-ray crystallography was used to elucidate the molecular mechanisms behind their interaction and formation of the IZUMO1–JUNO complex. The study found IZUMO1 to bear an elongated rod-shaped structure 90 Å in length, consisting of an N-terminal alpha-helical bundle IZUMO domain and a C-terminal immunoglobulin-like domain, connected by an intervening β-hairpin region via disulfide bonds. This central β-hairpin region was shown to provide the main platform for specific binding to the surface behind the ligand binding pocket on JUNO, which exhibits a single globular fold comprised of eight α-helices and four β-strands, stabilized by eight disulfide bonds. Hydrophobic and van der Waals interactions are the main contributing forces to the binding along with six hydrogen bonds. Subsequent cell–oocyte binding assays were successfully conducted using mouse cells expressing either wild-type or mutant Izumo1 proteins to confirm the functional relevance of the IZUMO1–JUNO interface in sperm–oocyte attachment. Overall the study provided a major development in determining the mechanisms of sperm-oocyte recognition and the IZUMO1–JUNO as an essential part of fertilization. The findings have potential applications in contributing to the development of new therapeutics relating to fertility, such as contraceptive agents.

Mark Hill September 2016 - This is a relevant article and summary for fertilisation topic. Added after the submission date. Assessment 4/5

Lab 2 Assessment

Primite Streak Cell Migration In Chick Embryo.png

Primitive Streak Cell Migration In Chick Embryo [1]

Mark Hill September 2016 - Image added with correct reference, copyright and student template. Assessment 5/5

Lab 3 Assessment

Mark Hill 31 August 2016 - Lab 3 Assessment Quiz - Mesoderm and Ectoderm development. Assessment 5/5


Lab 4 Assessment

Gastrointestinal Tract Quiz.

1

Match the germ layer with the aspect of the gastrointestinal tract it will contribute to.

  • A) Endoderm
  • B) Mesoderm
  • C) Ectoderm
  • 1. enteric nervous system
  • 2. epithelium and associated glands, associated organs
  • 3. smooth muscle, mesentery, connective tissue, blood vessels, associated organs

A1, B2, C3
A1, B3, C2
A2, B1, C3
A2, B3, C1
A3, B1, C2
A3, B2, C1

2

Select the processes in GIT development which DO NOT occur in week 4:

hepatic diverticulum development
differentiation of hepatic cells
recanalization of the GIT endoderm tube
enlarged lumen of the GIT endoderm tube
extension of the dorsal mesogastrium to form the greater omentum

3

The CORRECT adult structures which will go on to be formed from the Midgut division are:

stomach, upper duodenum, lower duodenum, jejunum, ileum, cecum, appendix
lower duodenum, jejunum, ileum, cecum, appendix, liver, gallbladder, pancreas
lower duodenum, jejunum, ileum, cecum, appendix, ascending colon, half transverse colon
jejunum, ileum, cecum, appendix, ascending colon, transverse colon, descending colon

4

Which of the following statements is/are CORRECT regarding abnormalities in GIT development:

Atresia is an interruption of the lumen whilst stenosis is a narrowing of the lumen
Meckel’s Diverticulum results from improper closure and absorption of the vitelline duct which connects the yolk to the primitive GIT during early development
Meckel’s Diverticulum is rare, occurring in 1/100,000 births.
Intestinal Malrotation usually presents in neonates and infants with bilious vomiting, bloody stools, recurrent abdominal pain, intestinal obstruction, abdominal distention, malabsorption/diarrhea, peritonitis and bile duct obstruction.
Intestinal Aganglionosis is a congenital abdominal wall defect which results in herniation of fetal abdominal viscera into the amniotic cavity.


Lab 5 Assessment

Course Feedback Questionnaire - Absent due to illness therefore could not complete in-class questionnaire

Lab 6 Assessment

Identify a known genetic mutation that is associated with cleft lip or palate: Mutation in X-linked TBX22 gene (T-box 22).

Identify a recent research article on this gene: [2]

How does this mutation affect developmental signaling in normal development:

Lab 7 Assessment

Duchenne Muscular Dystrophy

  • Populations Affected:
  • Current and Emerging Therapeutics:
    • Corticoteroids
  • Aetiology:
    • mutations in the protein Dystrophin
    • only apparent postnatally once muscles in use
  • Tissues Affected:
    • skeletal muscle
  • Diagnosis
    • prenatal genetic diagnosis
    • muscle biopsy
  • Animal Models for DMD:
    • MDX Mouse Model
Mark Hill 11 October 2016 - You have answered most of the questions, some of which are too general, and do not included any citations for your answers. Assessment 3/5

Lab 8 Assessment

Mark Hill 27 October 2016 Assessment 4.5/8

Lab 9 Assessment

Peer Assessment of Group Presentations: Assessment not completed


You could have added some peer assessment here, even if submitted late. 0/10

Lab 10 Assessment

Lab 10 - Stem Cell Presentations 2016
Group Mark Assessor General Comments

Group 1: 15/20

Group 2: 19/20

Group 3: 20/20

Group 4: 19/20

Group 5: 16/20

Group 6: 16/20

The students put great effort in their presentation and we heard a nice variety of studies in stem cell biology and regenerative medicine today. The interaction after the presentation was great.

As general feedback I would like to advise students to:

  • Never discuss M&M as a separate section in journal clubs. I gave this advice prior to the lab, but still most groups did talk through the M&M section.
  • Do not use your slides as cheat sheets, avoid text on slides, know what messages you need to get across, use images to illustrate these
  • Engage with your slides. Talk through them. Point at panels. Gauge your audience’s understanding by making eye contact with them
  • Avoid using abbreviations. Most people do not readily understand these and will lose track

Lab 11 Assessment

0/5


Cited research article on heart repair from review by Foglia & Poss (2016): Summary of findings: How the original research result was used in the Foglia & Poss review:

References

  1. <pubmed>20485500</pubmed>
  2. <pubmed>25373698</pubmed>