From Embryology

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Lab 1

Reserach Article 1

Toshimitsu M, Nagamatsu T, Nagasaka T, Iwasawa-Kawai Y, Komatsu A, Yamashita T, Osuga Y, Fujii T. Increased risk of pregnancy-induced hypertension and operative delivery after conception induced by in vitro fertilization/intracytoplasmic sperm injection in women aged 40 years and older. 2014 Aug 11. pii: S0015-0282(14)00607-4., PMID: 25123639



This article investigates the association between preconception fertility status and unfavorable pregnancy outcomes of women of aged 40 years and older who used the technology associated with in vitro fertilization/ intracytoplasmic sperm injection.

To do this, medical record of 330 women who aged 40 years and older and delivered a singleton were compared with 450 women who aged 30 to 34 years who delivered a singleton at same university maternity ward in terms of following criteria : - Incidence of pregnancy-induced hypertension, - Gestational diabetes mellitus, - Preterm birth - Low birth weight

  • Every women in aged 40 years and older and aged 30 to 34 years were also divided into following 3 groups based on mode of following conception method:

-spontaneous conception (SC) -in vitro fertilization/intracytoplasmic sperm injection conception (IVF-ICSI)

The result had shown that incidence of pregnancy-induced hypertension and the rate of operative surgery, which includes emergency cesarean section and instrumental delivery were statistically higher in IVF-ICSI group than the SC group due to elevated incidence of labor protraction. However there were no statistical difference observed in the frequency of gestational diabetes mellitus, preterm birth, or low birth weight between women aged 40 years and older and women aged 30 to 34 years old

Research Article 2

Asato K, Mekaru K, Heshiki C, Sugiyama H, Kinjyo T, Masamoto H, Aoki Y, Subchorionic hematoma occurs more frequently in in vitro fertilization pregnancy, Eur J Obstet Gynecol Reprod Biol., 2014 Jul 30;181C, PMID: 25126980



This article aims to investigate the correlation between subchorionic hematoma and in vitro fertilization (IVF) pregnancies

This was carried out by comparing the frequency of subchorionic hematoma between 67 women achieved pregnancy by IVF and 127 women pregnancy by non-IVF approaches and examined the risk factors for subchorionic hematoma in the IVF group.

The result had shown that the frequency of subchorionic hematoma was significantly higher in the IVF group (22.4%) than that in the non-IVF group (11%) (P=0.035). Frozen-thawed embryo transfer, parity≥1, and blastocyst transfer may contribute to subchorionic hematoma onset

--Mark Hill These are related to fertilisation and good brief summary (5/5)

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