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A Comparison Of The Growth Of The Body Dimensions Of Anencephalic Human Fetuses With Normal Fetal Growth As Determined By Graphic Analysis And Empirical Formulae

Juan C. Nanagas Institute of Anatomy, University of Minnesota

SEVENTEEN FIGURES

The teratological condition known as anencephaly is not an uncommon human malformation. It is obvious on the first inspection of anencephalic fetuses that, concomitant with the faulty or even complete suspension of development of the cranial portion of the head, there is a marked departure from the normal proportions of not only the facial region, but also of the other divisions of the body. These disproportions have received little attention in studies of congenital malformations.

This study was undertaken with the object of determining quantitatively the anomalous growth of this type of fetus and the changes in body—form associated with the partial loss or complete absence of the cranial vault and encephalon.

The present report was made possible by the use of the extensive data on normal fetal growth available in the Institute of Anatomy of the University of Minnesota. The writer wishes to express his grateful acknowledgments to Professor Scammon, under whom this investigation was conducted, and to Professor Jackson, Director of the Institute.

GENERAL DESCRIPTION OF MATERIAL

Fifty—seVen anencephalic fetuses were available for study. The sizes of these ranged from 279 to 502 mm. in calculated

crown-heel length (p. 466) and from 320 to 2750 cc. in body