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News - Rare Sesquizygotic Twinning
Twinning historic drawing
Twinning historic drawing by William Smellie (1697-1763)


Sesquizygotic twinning is a rare intermediate form of twinning, lying between mono-zygotic and dizygotic twinning, the twins can be maternally identical but chimerical for their paternal genome. This rare twinning event has been recently identified by a twin amniocentesis genotyping study[1] that showed twins that were maternally identical, but chimerically shared 78% of their paternal genome.

  1. Gabbett MT. etal., Molecular Support for Heterogonesis Resulting in Sesquizygotic Twinning. (2019) New England Journal of Medicine, 380(9), 842–849. https://doi.org/10.1056/NEJMoa1701313


Links: twinning | amniocentesis | NEMJ | UNSW News 29Feb2019 | Search Pubmed

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