Template:Leptin table

From Embryology
Leptin effects on female reproduction
Target Tissue Biological Process Biological Function Mechanism
Hypothalamus GnRH secretion Regulation of LH and FSH secretion Indirectly via kisspeptin
Pituitary Estrous cycles and ovulation FSH and LH release; LH plasticity and cyclicity
Ovary Ovarian steroidogenesis Estrogen production P450 aromatase; P450-17α hydroxylase
Ovary Folliculogenesis Low leptin promotes follicle development Promotes the transition of primordial to primary follicles
Embryo Embryogenesis Biophysical effect on embryo growth and quality Stimulates proliferation
Uterus Angiogenesis Stimulates metalloproteinase activity Inhibits terminal differentiation of committed giant cells
Table modified from:<pubmed>24908087</pubmed>