Template:Anderson2016 table2
From Embryology
Lesion | Start of Susceptibility to Malformation |
End of Susceptibility to Malformation | |||
---|---|---|---|---|---|
Interatrial communications | |||||
Oval fossa defect | 6 weeks (E13.5) | Term | |||
Sinus venosus defect | 8 weeks | 12 weeks | |||
Coronary sinus defect | 8 weeks | Term | |||
Vestibular defect | 7 weeks | 8 weeks | |||
Ventricular Septal Defect | |||||
Muscular | 8 weeks | Difficult to predict | |||
Perimembranous | 6 weeks | 8 weeks | |||
Doubly committed | 7 weeks | 8 weeks | |||
Atrioventricular Septal Defect | |||||
Ostium primum | 5 weeks | 6 weeks | |||
“Complete” | 5 weeks | 6 weeks | |||
Aortic coarctation | |||||
With VSD | 5 weeks | 8 weeks | |||
With intact ventricular septum | 8 weeks | Term | |||
Double Outlet Right Ventricle | 6 weeks | 8 weeks | |||
Transposition of Great Arteries | 6 weeks | 8 weeks | |||
Ebstein’s malformation | 6 weeks | 8 weeks | |||
Hypoplastic left heart syndrome | |||||
With mitral atresia | 5 weeks | 8 weeks | |||
With mitral stenosis | 8 weeks | Term | |||
Pulmonary atresia | |||||
With VSD | 6 weeks | 8 weeks | |||
With intact ventricular septum | 8 weeks | Term | |||
Other | |||||
Functionally single ventricle | 5 weeks | 6 weeks | |||
Tetralogy of Fallot | 7 weeks | 8 weeks | |||
Totally anomalous pulmonary venous return | 8 weeks | 12 weeks | |||
Tricuspid atresia | 5 weeks | 6 weeks | |||
Common arterial trunk | 5 weeks | 7 weeks | |||
Bicuspid aortic valve | 6 weeks | Term | |||
Notes | |||||
For approximate clinical Gestational Age GA add 2 weeks; number in brackets is mouse equivalent. Data Reference[1] | Links: heart | abnormal development | timeline | Category:Timeline |
Table 2. Summary of Timing (Post Fertilization) of Cardiac Susceptibility to a Drug-Induced Malformation | ||
---|---|---|
Lesion | Start of Susceptibility to Malformation |
End of Susceptibility to Malformation |
Interatrial communications | ||
Oval fossa defect | 6 weeks (E13.5) | Term |
Sinus venosus defect | 8 weeks | 12 weeks |
Coronary sinus defect | 8 weeks | Term |
Vestibular defect | 7 weeks | 8 weeks |
Ventricular Septal Defect | ||
Muscular | 8 weeks | Difficult to predict |
Perimembranous | 6 weeks | 8 weeks |
Doubly committed | 7 weeks | 8 weeks |
Atrioventricular Septal Defect | ||
Ostium primum | 5 weeks | 6 weeks |
“Complete” | 5 weeks | 6 weeks |
Aortic coarctation | ||
With VSD | 5 weeks | 8 weeks |
With intact ventricular septum | 8 weeks | Term |
Double Outlet Right Ventricle | 6 weeks | 8 weeks |
Transposition of Great Arteries | 6 weeks | 8 weeks |
Ebstein’s malformation | 6 weeks | 8 weeks |
Hypoplastic left heart syndrome | ||
With mitral atresia | 5 weeks | 8 weeks |
With mitral stenosis | 8 weeks | Term |
Pulmonary atresia | ||
With VSD | 6 weeks | 8 weeks |
With intact ventricular septum | 8 weeks | Term |
Other | ||
Functionally single ventricle | 5 weeks | 6 weeks |
Tetralogy of Fallot | 7 weeks | 8 weeks |
Totally anomalous pulmonary venous return | 8 weeks | 12 weeks |
Tricuspid atresia | 5 weeks | 6 weeks |
Common arterial trunk | 5 weeks | 7 weeks |
Bicuspid aortic valve | 6 weeks | Term |
Notes: For approximate clinical Gestational Age GA add 2 weeks; number in brackets is mouse equivalent. Reference: Anderson RH. Teratogenecity in the setting of cardiac development and maldevelopment. (2016) |