Talk:Lecture - Early Vascular Development

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Mol Syst Biol. 2010 Jun 22;6:381. Dissecting spatio-temporal protein networks driving human heart development and related disorders. Lage K, Møllgård K, Greenway S, Wakimoto H, Gorham JM, Workman CT, Bendsen E, Hansen NT, Rigina O, Roque FS, Wiese C, Christoffels VM, Roberts AE, Smoot LB, Pu WT, Donahoe PK, Tommerup N, Brunak S, Seidman CE, Seidman JG, Larsen LA. Source Pediatric Surgical Research Laboratories, MassGeneral Hospital for Children, Massachusetts General Hospital, Boston, MA 02114, USA. lage.kasper@mgh.harvard.edu Abstract Aberrant organ development is associated with a wide spectrum of disorders, from schizophrenia to congenital heart disease, but systems-level insight into the underlying processes is very limited. Using heart morphogenesis as general model for dissecting the functional architecture of organ development, we combined detailed phenotype information from deleterious mutations in 255 genes with high-confidence experimental interactome data, and coupled the results to thorough experimental validation. Hereby, we made the first systematic analysis of spatio-temporal protein networks driving many stages of a developing organ identifying several novel signaling modules. Our results show that organ development relies on surprisingly few, extensively recycled, protein modules that integrate into complex higher-order networks. This design allows the formation of a complicated organ using simple building blocks, and suggests how mutations in the same genes can lead to diverse phenotypes. We observe a striking temporal correlation between organ complexity and the number of discrete functional modules coordinating morphogenesis. Our analysis elucidates the organization and composition of spatio-temporal protein networks that drive the formation of organs, which in the future may lay the foundation of novel approaches in treatments, diagnostics, and regenerative medicine.

PMID 20571530


http://www.nature.com/msb/journal/v6/n1/full/msb201036.html

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Take the Quiz

1

Both blood stem cells and the endothelial lining of blood vessels arise from blood islands.

true
false

2

The region of the early heart tube that corresponds to the inflow and out flow respectively are:

inferior vena cava and aortic arch
portal artery and aorta
sinus arteriosus and cordus bulbus
truncus arteriosus and sinus venosus

3

Embryonic red blood cells only differ from adult cells in still having nuclei.

true
false

4

The embryo cardinal venous vessels which drain into the sinus venosus are:

anterior cardinal veins
common cardinal veins
inferior cardinal veins
superior cardinal veins

5

The embryonic heart rate rises throughout development.

true
false


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