Talk:Lecture - Early Vascular Development
Links only work with currently enrolled UNSW students.
Lecture page was last modified on 13 August 2012, at 04:19 been accessed 2,023 times.
Mol Syst Biol. 2010 Jun 22;6:381. Dissecting spatio-temporal protein networks driving human heart development and related disorders. Lage K, Møllgård K, Greenway S, Wakimoto H, Gorham JM, Workman CT, Bendsen E, Hansen NT, Rigina O, Roque FS, Wiese C, Christoffels VM, Roberts AE, Smoot LB, Pu WT, Donahoe PK, Tommerup N, Brunak S, Seidman CE, Seidman JG, Larsen LA. Source Pediatric Surgical Research Laboratories, MassGeneral Hospital for Children, Massachusetts General Hospital, Boston, MA 02114, USA. firstname.lastname@example.org Abstract Aberrant organ development is associated with a wide spectrum of disorders, from schizophrenia to congenital heart disease, but systems-level insight into the underlying processes is very limited. Using heart morphogenesis as general model for dissecting the functional architecture of organ development, we combined detailed phenotype information from deleterious mutations in 255 genes with high-confidence experimental interactome data, and coupled the results to thorough experimental validation. Hereby, we made the first systematic analysis of spatio-temporal protein networks driving many stages of a developing organ identifying several novel signaling modules. Our results show that organ development relies on surprisingly few, extensively recycled, protein modules that integrate into complex higher-order networks. This design allows the formation of a complicated organ using simple building blocks, and suggests how mutations in the same genes can lead to diverse phenotypes. We observe a striking temporal correlation between organ complexity and the number of discrete functional modules coordinating morphogenesis. Our analysis elucidates the organization and composition of spatio-temporal protein networks that drive the formation of organs, which in the future may lay the foundation of novel approaches in treatments, diagnostics, and regenerative medicine.
This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial Share Alike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.
- Cardiovascular System Development
- Cardiac Embryology Tutorial - Basic Cardiac Embryology | Intermediate Cardiac Embryology Advanced Cardiac Embryology
- Original Notes pages - Introduction | Abnormalities | Stage 13/14 | Stage 22 | Stage 22 Selected Highpower | Heart | Heart Rate | BloodBlood Vessels | Molecular | Lymphatic | Postnatal | History - Harvey
<pubmed>11891982</pubmed> <pubmed>12746463</pubmed> <pubmed>12807866</pubmed> <pubmed>11909814</pubmed>
Take the Quiz
UNSW Embryology Links
- Cardiovascular Movies Heart Movies | Heart Looping | Atrial Septation | Realignment | Ventricular Septation | Heart Septation Models | Historic Heart Movie |
- Other Cardiac and Vascular Movies Fetal Circulation (Before Birth) | Circulation (After Birth) | Aortic Branches to Glands (Kidneys only) | Aortic Branches to Glands (Gonads only)
- Cardiovascular Notes Introduction | Abnormalities | Stage 13/14 | Stage 22 | Stage 22 Selected Highpower | Heart | Heart Rate | BloodBlood Vessels | Molecular | Lymphatic | Text only page | WWW Links | Postnatal | History - Harvey
- System Notes
- Development Timeline