Talk:Gastrointestinal Tract - Colon Histology

From Embryology


Most bowel cancer symptoms do not indicate colorectal cancer and polyps: a systematic review

Adelstein BA, Macaskill P, Chan SF, Katelaris PH, Irwig L BMC Gastroenterology 2011, 11:65 (30 May 2011)

Colorectal cancer was associated with rectal bleeding (AUC 0.66; LR+ 1.9; LR- 0.7) and weight loss (AUC 0.67, LR+ 2.5, LR- 0.9). Neither of these symptoms was associated with the presence of polyps. There was no significant association of colorectal cancer or polyps with change in bowel habit, constipation, diarrhoea or abdominal pain. Neither the clinical setting (primary or specialist care) nor study type was associated with accuracy. Most studies had methodological flaws. There was no consistency in the way symptoms were elicited or interpreted in the studies.

Determinants of polyp Size in patients undergoing screening colonoscopy

Lowenfels AB, Williams JL, Holub JL, Maisonneuve P, Lieberman DA BMC Gastroenterology 2011, 11:101 (24 September 2011)

Results In both genders, size of the largest polyp increased progressively with age in all age groups (P < .0001). In subjects ≥ 80 years the relative risk was 1.55 (95% CI, 1.35-1.79) compared to subjects in the youngest age group. With the exception of family history, all study variables were significantly associated with polyp size (P < .0001), with multiple polyps (≥ 2 versus 1) having the strongest risk: 3.41 (95% CI, 3.29-3.54).

Meeting report - The future of medical diagnostics: review paper

Jerjes WK, Upile T, Wong BJ, Betz CS, Sterenborg HJ, Witjes MJ, Berg K, van Veen R, Biel MA, El-Naggar AK, Mosse CA, Olivo M, Richards-Kortum R, Robinson DJ, Rosen J, Yodh AG, Kendall C, Ilgner JF, Amelink A, Bagnato V, Barr H, Bolotine L, Bigio I, Chen Z, Choo-Smith LP, D'Cruz AK, Gillenwater A, Leunig A, MacRobert AJ, McKenzie G, et al. Head & Neck Oncology 2011, 3:38 (23 August 2011)