Talk:Book - Sex and internal secretions (1961) 2

From Embryology

I. The Hormone Theory of Sex Differentiation 76

II. Methods of Experimental Analysis 78

A. Grafting of Gonads or Gonad Tis sues in Bird Embryos 78

B. Grafting Experiments in Amphib ian Embrj'os 79

C. Use of Pure Hormones as Sex Dif ferentiating Agents 82

D. Sex Differentiation in the Absence

of Hormones 82

III. The Bisexual Organization of the

IiIarly Embryo as the Basis of Sex Reversal 83

IV. Experimental Reversal of Sex Dif ferentiation IN the Gonads 83

A. Bisexual Organization of the Gonad

and the Physiologic Mechanism

of Sex Differentiation 83

B. Sex Reversal in Amphibian Gonads 86

1. Constitutional differences and

the character of the reversal process 80

2. Parabiosis and grafting of the

gonad or the gonad primordium 87

3. Administration of steroid hor mones 91

C. Sex Rkv'ersal in Avian (Ionads. 95

1. Organization of avian gonads. . . 95

2. Effects of administering pure

hormones 9(i

3. Effects of grafting gonads into

the coelomic cavity 99

4. Sex reversal in vitro 100

D. The Problem of Sex Reversal in

Mammalian Gonads 100

1. Bisexual potentialities in the embryonic gonads of mammals 100

2. Bisexual potentiality in the em bryonic ovary of the rat 103

3. Experimental transformation

of the testis in the opossum. . . 105 V. The Role of Hormones in the Development OF the Accessory Sex Structures 110

A. Differentiation of the Embryonic

Gonaducts Ill

1. The Miillerian ducts 112

2. The male duct system 120

B. Derivatives of the Cloaca and

Urinogenital Sinus 121

C. External Genital Structures 127

D. Differentiation of Other Types of

Sex Character 129

VI. The Pituitary and the Differentiation OF Sex 132

VII. Group Differences in the Relations OF Hormones to Sex 134

VIII. The Organization of the Sex Primordium AND Its Role in the Differentiation OF Sex 137

A. Constitution and the Morphologic

Representation of Sex Primordia 137

B. Constitutional Factors and Physi ologic Differences in the Organization of Sex Primordia 138

C. Influence of Sex Genotype on the

Reactions of Sex Primordia 139

IX. The Time F'.^ctor in the Responses OF Sex Primordia: Receptivity

and "Critical Periods" 140

X. Specificity of Hormone Action and the Significance of P.\radoxical

Effects 141

XI. Time of Origin and the Source of

(ioNAD HoR.MONES 143

XII. A Comparison of the Effects of EmBRYt)Nic and Adult Hormones in Skx Differentiation 145

.\1I1. IvMBRYONic Hormones and Inductor

Substances 148

XIV. References 151