Talk:Advanced - Molecular Development

From Embryology

--Mark Hill 16:08, 8 November 2009 (EST) I was wondering whether there is anywhere to say something about the development of the heart vasculature (coronary arteries)? PMID: 11297508 PMID: 15599567

--Mark Hill 14:58, 28 October 2009 (EST)

  • Check your spelling, I think you need a single "s"
  • Elsewhere I prefer fetal rather than foetal.
  • There should also be a full description of the image and additional information available when I open images by themselves.
  • I think there should be research references available on advanced pages. In particular for these molecular factors. There is no information about how these factors signal (signaling mechanisms)?

  • The del22q11.2 candidate gene Tbx1 controls regional outflow tract identity and coronary artery patterning. Théveniau-Ruissy M, Dandonneau M, Mesbah K, Ghez O, Mattei MG, Miquerol L, Kelly RG. Circ Res. 2008 Jul 18;103(2):142-8. Epub 2008 Jun 26. PMID: 18583714
  • Myocardial Pitx2 differentially regulates the left atrial identity and ventricular asymmetric remodeling programs. Tessari A, Pietrobon M, Notte A, Cifelli G, Gage PJ, Schneider MD, Lembo G, Campione M. Circ Res. 2008 Apr 11;102(7):813-22. Epub 2008 Feb 21. PMID: 18292603

--Phoebe Norville 18:03, 2 October 2009 (EST)


Background Reading

--Mark Hill 01:44, 10 September 2009 (EST) beginning of a list of relevant factors related to cardiac development. Need to add links to OMIM database entries when new factors are added.

OMIM: Fgf8 | Gata5 | Tbx5 | VEGF | Wnt |

  • Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors Chulan Kwon, Joshua Arnold, Edward C. Hsiao, Makoto M. Taketo, Bruce R. Conklin, and Deepak Srivastava Proc Natl Acad Sci U S A. 2007 June 26; 104(26): 10894–10899. Published online 2007 June 18. doi: 10.1073/pnas.0704044104. PMCID: PMC1904134 | OMIM: Wnt
  • Required, Tissue-Specific Roles for Fgf8 in Outflow Tract Formation and Remodeling Eon Joo Park, Lisa A. Ogden, Amy Talbot, Sylvia Evans, Chen-Leng Cai, Brian L. Black, Deborah U. Frank, and Anne M. Moon Development. PMCID: PMC1780034 | OMIM: Fgf8
  • Gata5 is required for the development of the heart and endoderm in zebrafish Jeremy F. Reiter, Jonathan Alexander, Adam Rodaway, Deborah Yelon, Roger Patient, Nigel Holder, and Didier Y.R. Stainier Genes Dev. 1999 November 15; 13(22): 2983–2995. PMCID: PMC317161
  • Differential regulation of Tbx5 protein expression and sub-cellular localization during heart development Benjamin Bimber, Robert W. Dettman, and Hans-Georg Simon Dev Biol. PMCID: PMC1876776 | OMIM: Tbx5
  • Role of VEGF in organogenesis Jody J Haigh Organogenesis. 2008 Oct–Dec; 4(4): 247–256. PMCID: PMC2634330

About OMIM "Online Mendelian Inheritance in Man OMIM is a comprehensive, authoritative, and timely compendium of human genes and genetic phenotypes. The full-text, referenced overviews in OMIM contain information on all known mendelian disorders and over 12,000 genes. OMIM focuses on the relationship between phenotype and genotype. It is updated daily, and the entries contain copious links to other genetics resources." OMIM