Talk:2018 Group Project 1
Adrenal Medulla Development
|Projects 2018: 1 Adrenal Medulla | 3 Melanocytes | 4 Cardiac | 5 Dorsal Root Ganglion|
About this Discussion Page
The project discussion page is where your group members can post discussion on the project topic. This will be demonstrated in the practical tutorial in week 3.
Please follow these 3 simple rules:
- Never identify yourself or any other students by name, use only your student number.
- Only edit your own student page or your own group project page.
- Only add content that is both correctly cited and you have permission to reuse.
|Group Assessment Criteria|
| Science Student Projects
|More Information on Assessment Criteria | Science Student Projects|
- Introduction - section does include brief introduction of neural crest and identifies the specific topic to be covered on the project page. Would have benefited from an introductory image to balance the text section.
- History - covered early neural crest findings. The history section does not focus on the adrenal gland, in fact it is hardly covered at all here.
- Developmental time course - early development covered but not detailed in regard to specific components and fetal functional development.
- Embryonic origins - neural crest migration mechanisms a good inclusion in this section. Figure relating to BMP-4 (bone morphogenetic protein 4) should have been located in the section where this is described within the text.
- References - significant research literature cited in project including recent research articles. Would have liked more clear distinction in the text between "review" and "research" articles.
- Z5091101 - 101
- Z5112688 - 57
- Z5113627 - 52
- Z5160977 - 26; zero edits - 5; minimal edits - 8; Only 3 main edits days - 11 September 2018, 8 September, 8 October 2018
Assessment feedback provided on figure page. 10 images. Half the images are student drawn images, which is a higher ratio than it should be if development articles and been better covered.
Adrenal Medulla Histology Z5014972 Student drawn image relevant to project page. Not any required information included here in summary section. Should include a brief description and the source of of information used in preparing this drawing. The quality of the uploaded image also has quite poor contrast.
TH - positive cells Z5112688 Image relevant to project page. Not all required information included here on summary section, missing link to reference. Should also include which species the study has been carried out in and included the reference in the figure legend on the project page, as well as in the associated text.
chromaffin progenitors Z5112688 Image relevant to project page. Not all required information included here on summary section, missing link to reference and student template . Should also include which species the study has been carried out in (chicken) and included the reference in the figure legend on the project page, as well as in the associated text.
Peer Reviews (Lab 10)
Z5229431 (talk) 16:14, 8 October 2018 (AEDT) The content under the history section is very well elaborated and thorough. It would be good to further develop the content in the rest of the sections similarly to what is being done in the history section. Under the subheading "Developmental time course", it will be nice to include a timeline for readers to better visualise the events occurring over the period of the development of the adrenal gland; a diagram works fine as well!
There appears to be a lack of references under the section "Tissue/organ structure", but the content inside is well developed and progresses smoothly. Under "Molecular mechanisms/factors/genes", it would be great to clearly identify the type of transcription/growth factors that influences the differentiation of cell types in the adrenal medulla mentioned under "Tissue/organ structure". The transcription/growth factors can be divided into smaller subsections for each of the factor as well before further elaboration is made.
Likewise, under the section "Animal models", subsections of the different animal models studied can be listed out, highlighting a few of the prominent key findings that are discovered on ox, sheep, swine and mice that was mentioned in the first paragraph of the section. It would be good to expand on all the findings and references listed in the last paragraph of the section and categorise them into the respective subsections.
Overall, apart of the missing content in some of the subheadings, the overall flow of the information is smooth and easy to digest. With some tidying up of the reference links and further elaboration in the content, the page would be good to go! Keep pushing and include more images wherever possible because it really helps to grasp the interest of the readers and also make the content easier to comprehend.
Z5229549 (talk) 16:07, 6 October 2018 (AEST) Content on a whole was relatively smooth to read, not too much technical jargon that is often seen in more off-putting texts. The inclusion of self-drawn images brings a refreshing colour to the overall page, and seem rather accurate too, though the arrangement and positioning of the images and text could use some readjustment.
However, there are still some headers that are lacking content, presumably still under editing and would be up soon. It also would be to some diagrams of the several experiments mentioned under animal models instead of just a large block of text.
Overall, aside from several empty headers, the ones currently there more or less have the content nailed down, though several polishings and edits could be made.
Z5229185 (talk) 17:45, 4 October 2018 (AEST) I feel that the introduction sounded a bit off as referring to neural crest as a term seems rather inaccurate. A good history of the neural crest cells was provided and it is quite detailed (in fact it may be too detailed as it seems really long).
I really like the hand drawing of the neural crest but I feel that it would look much better if you shifted the image to the right rather than let it take up the whole space.
The content was pretty easy to follow and digest, so good job on that! You might want to take note on some errors in punctuation throughout the wiki page but since its just a draft, it isn't that big of an issue for now.
The animal models section was really detailed and quite well written but the references need to be edited properly in the right format. I'm also a little confused as to why the picture of the "cascade of cathecholamine synthesis" is found right beside the Animal model section, you may want to adjust this!
There are a few references present at the end of the page, but I assume this is because the other references have not been formatted properly yet.
Overall good job with the page so far! I can see that the flow is some what smooth already (except for the empty sections) but just take note that there are still a few tweaks to be done with the referencing and placement of images!
- Perhaps describe the neural crest as a “structure” instead of a term. Great use of the student-drawn image as a guide! Overall, good simplified history.
In the normal structure and function region; good but rather brief discussion of the physiology and structure. perhaps a little bit more, and maybe an image- unless you merge it with the related anatomy component. Really love the adult adrenal gland and the effort behind it. Only complaint would be that perhaps it would have been good to have the regions of the kidney (medulla, cortex etc).
The description of the role of the adrenal medulla is very well-written; concise and seemingly accurate. Perhaps include the proper dot point structure instead of the >. The image drawn illustrating the cascade of catecholamine synthesis is also very good and I personally found it to be a helpful guide. However, it needs to be edited and correctly formatted for the webpage.
The first two sentences of the animal models section may be combined into one. Proof-reading required eg. as explained above ‘nueral’! Who is Ahonen- Is an in-text reference needed here? Perhaps this paragraph belongs in the current research section as the animal used hasn’t been mentioned. Please review this bit as the information provided is good and relevant but maybe in the wrong section.
In the current research section, the second sentence says ‘we generated’ … who are you referring to? The information here seems correct but was also quite advanced with numerous terms that I couldn’t understand- however it shows great research so well done!
Overall, great work guys! Keep it up and move along with the project consistently! Perhaps include some images from the experiments you’ve described and some more high-tech images- although the ones you have drawn are also excellent! :) **
The beginning introduction is good and very detailed which is excellent as it shows adequate research has been applied but it may be too in depth as the project pertains to the adrenal medulla. But after reading it all it transitions nicely into the project so I don't mind all of the details that much. The information is organized and is well constructed in the first section of this project I like the time frames and each description under each, maybe use more than one reference for the intro so it is not all from one source. other than that the intro is really good.
For the developmental adult section, it is either not researched or not started, I would just remove it as the rest of the project is put together and the adult function is not super important. Also, the developmental time course would be really cool to have to see the steps involved in the creation of the medulla, if not added not a big deal.
The hand drawn figures are really nice add a certain flare to the project which i think is sweet.
Other than that minor edits need to be made and this project is polished, some sections need to be researched more as there are still two weeks left until it is assessed, so plenty of time to polish.
Group Project 1: The History section is very detailed - more weight on the history of neural crest discovery related to the adrenal medulla specifically would be appreciated, as this is your topic, but I do think that it is good that you have maintained a focus on neural crest.
I think your section on genes and transcription factors is well described - I like that you have given a mouse model example. I presume the links to the sites will be added as proper references later. I also think the image of the cascade of catecholamine synthesis is helpful for those interested in the pathway, though its location is currently too far away from this section on the page. However, this is a minor issue and something that might be tidied up nearer the end of the assignment.
You currently don’t have any abnormalities/abnormal development information. It would be nice to see some example here such as Congenital Adrenal Hyperplasia.
In “current research” you have copied and pasted the introduction from the article cited. This definitely needs to be put into your own words, and maybe simplified as currently it is quite difficult to understand.
This project is good because it appears to have a decent number of headings that they are going to address that covers all the aspects of the embryonic adrenal medulla. It has a very detailed history that the reader can easily follow, as well as a simple student drawn image which is good to see on the page. The developmental time course is brief and addresses what it needs to. There is also good information on the tissue structure and function, as well as on its role and the factors involved in its development. The project is also good in including animal model and current research examples. The two chalk diagrams are very detailed and easy to understand.
The introduction has not been written yet, but that’s alright as it can be saved for the end of the project. Embryonic origin still needs to be written about, and should have a lot of information, as well as the abnormalities of development. The referencing is confusing at the bottom of each section and there should be more references in the reference list. There should also be images that aren’t student drawn and there should be more of them. The glossary also needs to be updated.
In terms of improvements, maybe an educational video could be added about the origin of the adrenal medulla or the developmental time course. A list describing what the acronyms mean could also be really helpful to the reader. The arrangement of the images could be neater but that is saved for the end of the project.
Overall. I think this is a really good project that shows a lot of effort and work being done as it is informative but easy to follow.
Z5229597 (talk) Your project includes a lot of information and carefully chosen pictures and diagrams, but I think that more research needs to be conducted to extend the Reference list and to add more information to sections that are currently lacking.
I am a little confused as to whether you are going to include a separate introduction paragraph, or if the history portion is where you want the reader to begin reading from. I think there needs to be some format editing to clarify this distinction. In regards to you history section, you include so much detailed information, but I believe that there is too much information that is irrelevant towards your specific topic. Even though its well organized and you share a lot of detail about the research history of neural crest, this section seems to be taking up a lot of space in your project. Even though you do mention adrenal medulla in your history section, it is not the focus and is only mentioned very briefly. Specific historical research that is directly about neural crest cell contribution directly to the adrenal medulla seems to be absent, but it should be the focal point.
In regards to the Embryonic Origins section, there is currently only a link in one of the sections which needs to be replaced. Also, I think you include a lot of detail in the Developmental Time Course section, but it might be more clear to format that information as a timeline. As another formatting suggestion, if you are going to include a numbered list in your Tissue/Organ Structure, I don't think that it should be included directly in the paragraph.
Your Molecular Mechanisms/Factors/Genes section and Animal Models section seem to both have relevant and appropriate information in them, but I believe that some subsections in them, such as Gene and Transcription Factors involved with Adrenal Medulla Development, need more information considering how integral these factor are to understanding how neural crest cells form the Adrenal Medulla. I think also the animal models section would benefit from a few subheadings, since it seems like there is a lot of information there but it is currently a little hard to follow. In both of these two sections though, I really enjoy the colorful image choices!
There are still some links scattered throughout your page that aren't included in the reference section, and some of the sections still do not have any information under them.
Z5229177 (talk) 16:24, 8 October 2018 (AEDT) The history of neural crest was well-described and detailed, considering the different discoveries made. However, it is a too lengthy and would be good to link the history of adrenal medulla to neural crest under the history section as that should be the main focus of the project.
For Developmental time course, I feel it might be good to have a timeline to show the different weeks of development and differentiation of the cortex and medulla to add on to the existing content that is already there. This might help readers to understand better.
Sections such as embryonic origins, developmental/adult function, and abnormalities/abnormal development still needs to be worked on as they are currently empty and lacking content.
Overall, the content is detailed and understandable by readers. Good job on the done parts and good use of the self-drawn figures! They are easy to understand and looks refreshing apart from the normal images or figures found online or on journal articles. Just need to brush up on those that have yet to be filled in, and also the references portion need to be listed out neatly.
The history section seems to be off topic it goes into detail about the nueral crest alone when emphasis on the history behind the adrenal medulla would be more fit to the topic of your project. The embryonic origins section seems to have nothing underneath it .I am unsure if the developmental time course is a subheading to the embryonic origins section because the information provided under developmental time course seems to belong to the embryonic origins section. Sorting this out so that it is clear for the reader would be helpful.
For the tissue structure and adult function portions there is nothing under the adult function but there is information about the adult function under the tissue structure as well , which is alspo confusing. The information is clear as to what it is talking about in the tissue structure section however its just confusing to know when the page will be talking about the adult function as it seems misplaced. The related anatomy under the tissue structure section is also well represented but seems to have no sources .
The information under the mechanisms factors and genes section is very brief which is not an issue but some parts could use further explaining ,such as naming the multiple key contributors the SOX gene provides. There are also links provided and it may be helpful to explain what those links are so readers know what they are looking for when clicking on it.
Abnormalities section is not written , and the animal models section looks good it presents good information that is easy to follow. I would just suggest adding references or links that describe what the link is before students click on it so it is clear .
The current research lab section does not seem to talk about specifc research but more so a broad idea ,it will be helpful to have links to some of those research labs for students interested in following up , as well as a link that is labeled .
Overall good start to the project it seems to need more research and more references throughout other than that its good.
Group 1 discussion:
A really good review article can be found here: https://link.springer.com/article/10.1007%2Fs12022-009-9070-6 as well as here: https://www.jstage.jst.go.jp/article/jvms/66/6/66_6_635/_pdf ( Z5113627 )
A paper with some info on discovery/history https://www.ncbi.nlm.nih.gov/pubmed/19179766
Can we please add normal anatomy of the adrenal medulla as a subheading - normal anatomy of adult medulla Was history referring to the history of discovery?
make a schematic drawing flow diagram outlining briefly history of neural crest
History of endocrine development (add to intro)
https://onlinelibrary.wiley.com/doi/full/10.1002/dvdy.21513 Z5091101 (talk) 16:56, 12 September 2018 (AEST)z5091101Z5091101 (talk) 16:56, 12 September 2018 (AEST)
Z5091101 (talk) 11:46, 4 September 2018 (AEST)z5091101Z5091101 (talk) 11:46, 4 September 2018 (AEST) https://clinicalgate.com/neural-crest/ Want to upload either image - https://clinicalgate.com/neural-crest/ - https://upload.wikimedia.org/wikipedia/commons/3/3d/Figure_43_06_01.jpg
Origin is from neural crest cells; ectoderm
Hey guys, do you think molecular mechanisms should be underneath embryonic origins and developmental time course before embryonic origins
developmental time course
The tissue and organ structure of the adrenal medulla should be understood with regard to its specialized function within the sympathetic nervous system.
Prenatal adrenal gland development has been described in numerous published reports covering a wide variety of species, including the ox (Katznelson, 1966; Wrobel and Suss, 1999), sheep (Davies, 1950; Wintour et al., 1975; Upadhyay and Zamboni, 1982; Naaman‐Reperant and Durand, 1997; Grino, 2004), swine (Sokolov et al., 2006) and mouse (Waring, 1935; Ikeda et al., 1994; Sass, 1996; Nyska and Maronpot, 1999; Bland et al., 2003; Val et al., 2007). Adrenal gland development also has been extensively described for humans as well (Kolliker, 1879; Minot, 1892; Zuckerkandl, 1912; Wieman, 1920; Ikeda et al., 1981; Langlois et al., 2002; Hanley and Arit, 2006), One‐Humped Camel (Camelus dromedarius)
current research (labs)
Week 4 researching:
- developmental time course
- developmental/adult function
- tissue/organ structure
- Mansfield CW, Carr BR, Faye-Petersen OM, Chen D, Xing Y, Rainey WE & Parker CR. (2011). Differential gene expression in the adrenals of normal and anencephalic fetuses and studies focused on the Fras-1-related extracellular matrix protein (FREM2) gene. Reprod Sci , 18, 1146-53. PMID: 22031191 DOI.
- Yamaguchi-Shima N, Okada S, Shimizu T, Usui D, Nakamura K, Lu L & Yokotani K. (2007). Adrenal adrenaline- and noradrenaline-containing cells and celiac sympathetic ganglia are differentially controlled by centrally administered corticotropin-releasing factor and arginine-vasopressin in rats. Eur. J. Pharmacol. , 564, 94-102. PMID: 17350615 DOI.
- Bronner ME. (2012). Formation and migration of neural crest cells in the vertebrate embryo. Histochem. Cell Biol. , 138, 179-86. PMID: 22820859 DOI.
- Xing Y, Lerario AM, Rainey W & Hammer GD. (2015). Development of adrenal cortex zonation. Endocrinol. Metab. Clin. North Am. , 44, 243-74. PMID: 26038200 DOI.