Talk:2016 Group Project 2
|Signalling: 1 Wnt | 2 Notch | 3 FGF Receptor | 4 Hedgehog | 5 T-box | 6 TGF-Beta|
|Here are some starting places for the topic. Can be patterning, differentiation, etc. as long as a developmental signal process/pathway.||
|Group Assessment Criteria|
| Science Student Projects
|More Information on Assessment Criteria | Science Student Projects|
- History table useful and referenced.
- Tables in general are well organised and formatted on this project page.
- youtube video was a useful educational inclusion to the project page.
- Quizzes (3) are useful inclusions when used correctly.
- Which organ does Notch exert lateral inhibition to differentiate endocrine cells? (heart, central nervous system, skin, pancreas) as pancreas is the only "obvious" endocrine organ most students would guess this option.
- In which animal (as described in this section) has it been shown that defective notch signalling leads to thinning and fragmentation of skeletal muscle fibres? (Drosophila melanogaster, I don't know!, Caenorhabditis elegans, Danio rerio) Useful but the Zebrafish option was directly above the quiz question.
- What is the name for the collection of rib and spine abnormalities that result from interruption in the Notch pathway that leads to inhibition of somite segmentation in the embryo? (Alagille Syndrome, T-cell acute lymphoblastic leukaemia, Spondylocostal Dysostosis, CADASIL) Your answer when exposed provides useful information about each abnormality. Try not to use acronyms in quiz options.
- Want to Read More About Notch? collapsible tables are well used here as they extend concepts from the project page without "cluttering the page concepts".
- OMIM (Online Mendelian Inheritance in Man) database links always a very useful inclusion. You could have added more associated with the link, perhaps spelling out the acronym.
- Z3462474 - 106
- Z5015014 - 74
- Z5014803 - 17 (4 October 2016, 27 October 2016, 18 August 2016)
- Z3491219 - 7 (19 August 2016; 25,26,27 October 2016) only 2 blocks this is not an "ongoing contribution" to the group project.
Summary of canonical Notch signalling Z5015014 reference, copyright and student template included. Abbreviations are shown with the image information. Image relevant to project page, figure legend is a good description.
Simplified Scheme of the Roles of Notch in Cardiac Development Z3462474 Student drawn image with source reference. This diagram is a little too simplified, not clear to me what this adds conceptually to the project page.
Simplified Diagram of Roles of Notch in Neuronal Differentiation Z3462474 Student drawn image with source reference. This diagram is a little too simplified, not clear to me what this adds conceptually to the project page. Similar comment to the previous.
Animals Whose Developmental Processes are Affected by Notch Z3462474 Similar comment to the previous 2 figures. Not informative enough in content.
Abnormal pectoral fins are formed in Notch signalling disrupted larvaeZ3462474 reference, copyright and student template included. Image is "hidden" in the collapsible table and could have appeared on the page to balance the text.
Loss of NOTCH1 expression in proximity to calcific nodules in human aortic valves Z3462474 reference, copyright and student template included. Image relevant to project page, figure legend is detailed, but could have also included a description relevant to the signaling pathway.
- This youtube video was a useful inclusion to the project page. You could have also included a brief caption beneath the video explaining what it would show.
Tips from Mark Hill about our wiki pages
- in the introduction:
- Describe what the signaling pathway does,
- what the project page is going to talk about
- Make limitations as to what you will cover and what you will not cover
- Describe the importance of that signaling
- don't need to reference glossary
- quiz is a very useful resource
- make sure the reference list is sorted properly so no multiple entries for same reference
- if you use any complicated terms/acronyms in a diagram make sure the acronyms are listed below the picture on the page so it is easier for the reader to understand
- videos are a good extra to have on the page (make sure they can play on the page)
- include what is still unknown about the signalling pathway - read the discussions of recent papers to see what is still unknown/future directions of research
comments specific to our page:
- the history timeline needs to be referenced at each point (there should be a research paper referenced for each point)
- if table is based upon a review say that at the top with a link to the reference
- link to embryology pages for background information for readers (e.g. i linked the cardiac development page at the top of the section about notch in cardio development)
- make sure the quiz answers have descriptions as to why the correct answer is true and why the others are wrong
- OMIM links are good
- make sure further reading section links to well-explained, current articles
Z3462474 (talk) 10:36, 26 October 2016 (AEDT) Yep I'll work on CNS and other systems today, I think Tarika said she did outflow tract for CVS so I'll leave that bit for now! I think also history needs updating so I'll try work on that, and do a big proof read either today or tomorrow as well :)
Z5015014 (talk) 16:24, 25 October 2016 (AEDT) hey pals, I think the main sections we need to fill out a bit more content on are Notch in embryonic development of CNS + other systems, animal models of Notch (especially knock-out models), and history/timeline. so if you could focus on adding stuff there then I think our page will be great! and I'll finish off the molecular pathway part.
Z3462474 (talk) 08:21, 12 October 2016 (AEDT) Hey everyone i have an idea based on some of the feedback we got from the peer reviews saying to make our page more 'student friendly' and maybe incorporate a quiz, I was thinking at the end of each subsection we could have 1 or 2 quiz questions for people to test themselves on. I thought this might be better than just one big quiz at the bottom since it'll keep people involved as they read through the page. Let me know what you think!
Z5015014 (talk) 12:31, 21 October 2016 (AEDT) I changed some of the formatting of the images but if you don't like the placement then we can change it back! also I've put in a lot of tables, I don't think all of them will be necessary so let me know what you think or if we should keep them all.
To do before Friday
Z3462474 (talk) 14:48, 14 October 2016 (AEDT) hey guys please read through this and indicate what you are able to work on before the due date next Friday (i think its friday but am now having trouble finding any solid info on the wiki page, i had this friday written in my diary as the due date)! Let me know if I've forgotten anything we need to cover :)
For Everyone to do:
- Drawings to support explanations (I'm happy to do ones for the different development systems since I've been working on these areas)
- Glossary for any words in your section that aren't common knowledge
- One quiz question for the end of each of the content sections -Present under a subheading ‘Test Your Knowledge on (Section)’
- Fix anything you see needs fixing from the feedback I posted that refers to your section
Subheadings to fill in:
we could put our names under each one we will do
- Extend the history timeline
- Receptor subtypes summarised in a table (see feedback) - Lydia
- This textbook chapter looks like it has a good diagram (figure 8.1) summarising the Notch targets Chapter Eight - Notch Targets and Their Regulation
- After non-canonical section: Video/simplified representation (maybe a table or a simple drawn diagram?) comparing canonical and non canonical - Lydia (I'll try!)
- Neuro development - Elisa, Lydia
- Other development -
- Introductory sentence under Animal models heading - Elisa
- Current Research and Future Directions
- Further Reading (maybe just linking and displaying some interesting resources for notch, student friendly ones) - Lydia (I'll link some good review articles I've found) - Elisa (I've got a couple too I'll add!)
things we can improve
Z3462474 (talk) 08:15, 12 October 2016 (AEDT) hey guys I've read through the peer reviews and have jotted down the main aspects that other students have suggested we improve so thought I'd post them here so we don't all have to read through all the reviews: (my notes are not in any order of importance)
Z3491219 hey sounds good .. i'll try and find a good video on non canonical pathway and once again i've done the parts but i have to reference them and put it up. i have a group presentation tomorrow so i'll try and finish my part by wednesday :)
- add more info under CNS
- better summarise/explain the differences between canonical and non canonical pathways especially in terms of embryology, perhaps using a video
- add more terms to glossary, a number of terms throughout our page were unfamiliar to readers
- add more interactive and engaging features such as a quiz or video
- investigate more organ systems and how notch plays a role in their development
- draw pictures ourselves instead of using other people's, then we can emphasise the more relevant parts
- stop saying ‘and colleagues’ so much (this is my section haha i will fix it!)
- extend the history section past 1989
- expand on how the canonical pathway is tightly controlled, is it through transcriptional regulation or other mechanisms?
- Alagille Syndrome - how is the mutation brought about?
- Add a ‘Further Reading’ section linking interesting articles or facts
- Add references to the history section
- Change the images to have their descriptions/captions on the page so its easier to understand
- Add other forms of media such as videos
- Canonical pathway: mention specific gene targets of Notch
- try to see if we can add information on how Notch’s receptors come about (what genes transcribe the receptors, how the protein is processed or expressed before the pathway can start to work)
- summarise receptor subtypes involved in different pathways, their role in embryonic development and abnormalities related to embryonic development, in a table
- Make introduction a bit easier to understand with a hand-drawn diagram supporting the information
Z3491219 hey guys I've done non canonical pathway , transcriptional regulation of NOTCH signalling, congenital heart defects and development of the outflow rate. i just need to figure out how to upload it :P
Bystander Effect Fuels Human Induced Pluripotent Stem Cell-Derived Neural Stem Cells to Quickly Attenuate Early Stage Neurological Deficits After Stroke
Google Slides Document for making our presentation
Positive aspects of the project and suggested improvements: Group 2 has provided a variety of different topics related to the Notch receptor, such as its molecular pathway, its role in embryonic developing both in humans and animals as well as abnormalities caused by disruption in the receptor’s normal function (criteria 6). This variety is excellent, as it informs the audience of various aspects of the Notch receptor ranging from normal to abnormal development as well as newly emerging research (criteria 1.). Group 2 has also utilised both tables and diagrams to represent Notch receptor’s history and signalling pathway respectively (criteria 2). The use of diagrams is a great idea as it allows peers to understand the complexity of the signalling pathway in a much simpler manner (criteria 4).
In addition, the authors have correctly utilised in text citations when referencing all sources and have created a list of references at the conclusion of the page (criteria 3). Group 2 also investigated specific components of organ development which was another magnificent feature of their page, such that they divided cardiovascular development into different stages including “heart valve development” and “trabeculation” for example. This allows for an in-depth understanding of organ development with respect to the Notch receptor, rather than a general overview of the receptor’s involvement (criteria 5 and 6). The authors also have extended beyond Notch’s involvement in human embryonic development by exploring its role in animal embryonic development (criteria 5).
Although there are many positives, a possible improvement to this outstanding wiki would be to include a table of the different types of Notch receptors that exist and their different roles in embryonic development. This will allow the audience to understand that there is not just a single receptor playing a role in embryonic development but multiple. Another suggestion would be to add more subheadings under the “Central nervous system” development, as this subheading appears to have a lot less information compared to others. Also, it is obvious that there are different pathways for this receptor such as “Canonical” and “Non-canonical”, therefore it would be a great idea to include a youtube video to summarise these pathways and reinforce the in-depth description already provided on the page.
Negative aspects of the project and suggested improvements:
It was also noticed that a variety of terms were utilised which were not defined in the glossary such as “cyclins”, “pluripotent stem cells” and “ligands” for example. It is important to consider that the wiki should be able to teach at a peer level (criteria 4), as some students may not understand these terms. Therefore it is important to define them so audiences can develop a coherent understanding of the information. Another negative feature of the page was that it lacked interactivity. Indeed the page is very informative, however to further engage the audience, a suggestion would be to include a set of multiple choice questions at the end of the page which tests peers about the content covered.
It was also noticed that the page had a very limited number of subheadings regarding Notch’s involvement in embryonic development. A possible improvement would be to investigate Notch’s involvement in organ systems other than Cardiovascular and central nervous system. This will add a greater variety to the page and provide a greater depth of understanding regarding the role of the Notch signalling pathway in embryonic development.
Group 2 Peer Review
Really well organised structures! Nice and clear. The history part is really good. It makes your project both educative and attractive. After the history, the molecular background has been well explained. You guys have really looked into this pathway in depth and understood it clearly. I'm really looking forward to reading the non-canonical and the regulation part of the molecular basis. As ANAT2341 is an anatomy course, you guys have perfectly caught the main point of this project. Most of your following paragraphs focus on the anatomical aspect related to Notch signalling pathway. Moreover, you have also identified some abnormalities associated with Notch which makes your page look really good (almost like a lecture note page)!
Just a few points about your page. Firstly, I think it might be better if you guys can find another or draw a picture yourselves showing important components of this pathway. The one that you guys have now looks a little bit massy. I think you guys can photoshop the picture a little bit, just to make the important components more obvious. Moreover, I believe that the differences between canonical pathway and non-canonical pathway are more than component differences. Maybe address more about what does the canonical pathway do and what does the non-canonical pathway do, so that those pathways can be differentiated better. However, since you haven't pasted you non-canonical part yet, it hard to judge whether or not my comment is appropriate.
Overall, I think this page is really good, for it has a lot of attractive contents and well structured which makes us easy to follow. What you guys need is just to complete it. Great job!
Group 2 Peer Review
At first glance, I was blown away by your team's page. Definitely very impressive and understandable. The key points relating to the Notch signalling process are definitely clearly described however I may recall Dr Hill requesting that teams steer clear of clinical effects of genes(citation needed!). The choice of headings, sub-headings and diagrams show more than a good understanding of the topic area, it may be useful to include a table that summarises the various aspects of the Notch pathway so that readers realise there are different receptors. The content is cited correctly, however, I would not mind reading 'et al' instead of 'and colleagues' more often, I got sick of reading 'and colleagues'.
The information presented is mostly peer friendly in the context of a simple introduction but your glossary certainly needs updating, there are a lot of terms that a lot of students would not understand and a comprehensive checking of your page will offer you a list of words that you need to define. Also lacking are sketches presented in your own hands, instead of reusing published images. There is plenty of evidence that suggests your team has went beyond the formal teaching activities. In the context of the aims of the embryology course, you guys have emphasised the embryonic role of Notch but the aspect of developing technologies appears to have been ignored to an extent.
Overall, you guys have done a very impressive job that only requires minor tweaking, namely slight editing in the context of in text referencing, more comprehensive glossary as well as checking the course aims of embryology to incorporate the second criterion regarding technology. Excellent work!
Well done on the progress you have made thus far! You guys have chosen appropriate headings and subheadings that effectively break down the Notch signalling pathway. A coherent introduction has been provided, giving a taste of what is to be expected in this project. The use of a table to explore the history of this signalling pathway was particularly useful in making the information understandable and relevant. Though you have done an excellent job, was there any reason you stopped at 1989? It may even be useful to create a brief timeline of events, thus allowing you to better explore current areas of research by considering past studies that have been performed.
You’ve provided a good overview of the canonical pathway with the appropriate use of a diagram which aids reader’s understanding of the information provided. In saying this, I think it would be useful to expand on how this pathway is tightly controlled, is it through transcriptional regulation or through other means? In addition, it may be useful to explain the differences in the non-canonical and canonical pathways in terms of their significance and role in embryonic development. I’ve noticed that you have provided a general overview of the role of Notch signalling pathway in embryonic development, do these roles differ between the canonical and non-canonical pathways?
In addition, it’s good that you have included the role of the Notch signalling pathway in animal development as it explores the scope of this pathway beyond human embryology but it may also be useful to explore animal models in research, especially considering that the ‘first description of a “notch” defect’ was discovered in Drosophila. By combining the role of animal models in expanding our knowledge of the Notch signalling pathway with the effect of this pathway in animals, it provides a more rounded approach to explaining and discussing this signalling pathway.
I particularly like how you have included statistics in the ‘Abnormalities of Notch signalling’ section as it provides insight into the importance of this pathway in embryological development. You have successfully described the type of mutation that results in the particularly disease in most cases except for Alagille syndrome. More detail in how the mutation causes the syndrome would be useful with an explanation of how the mutation is brought about.
Overall, you guys have done a fantastic job! You have appropriately referenced and cited all the information provided and have included useful flowcharts, tables and diagrams that aid understanding of the text provided. Providing more detail to each of the sections and communicating with all your team members in the discussion page will ensure that you produce an excellent project! Good luck!
Group 2 Critical Assessment
A job well done with the introduction! The introduction is brief however manages to link the topic to embryonic development, different medical conditions, whilst also outlining the function and elements of the pathway. Being brief and succinct, it allows the viewer to continue exploring the page without experiencing confusion at the first lot of information. Further to this, the history of the pathway is formatted well and is not too overwhelming or boring. It is evident you have decided ‘Current Areas of Research’ will also be included in your page which is a great idea as you have included a section on History. This would ensure your Wiki flows well, and covers the pathway from start to finish.
Images have been included to visually represent the elements of the general pathway, as well as the elements specific to the pathway in cardiac development, which forms a great aid for viewers in understanding the content. Videos explaining the different canonical and non- canonical pathways could also be included for viewers with a video learning preference.
Use of in text citations neatens the layout of information and enables viewers to access the article should they find the point interesting. Numerous subheadings have been included which further break down the page into small sections of information. This is a fantastic positive as viewers can locate information in which they are interested in easily instead of having to read through long paragraphs of text. I feel as if linking the topic clinically is extremely important which you have done a great job in! Along with the text explaining the disease, you could possibly include a table stating the disease, the mutation, and the symptoms for viewers after a more easy, accessible format.
Throughout the topics covered, a lot of jargon is utilized, however a full glossary has not been provided. A glossary should definitely be included for terms such as ‘gastrulation’, ‘kinases’ or ‘cardiogenesis’ in order to satisfy criteria 4. Additionally, the page does not cater for viewers interested in further reading up on the topic. To ensure criteria’s 4 and 5 are met, links to interesting facts or articles could be provided so the audience has access to more information if they would like to further their understanding. With a few improvements this Wiki page can definitely prove helpful in understanding the pathway!
Group 2 Peer Assessment
Your project is quite good and seems to be on the right track. All your references have been done in-text and have made it really easy to make one’s way to the research article to read more about certain points. Not only that, you have appropriately abbreviated your terms by using the full name initially, and I can see that you have a glossary section which should be beneficial in the future when more terms are added. Your history section is well presented but, it might be important to add references to the papers of the main points of discovery in your history section as to allow people to easily access and find the full article regarding the discovery.
The fact that you have added pictures is quite handy when it comes to using it as an aid to accompanying passage. With regards to the image legend, maybe add more information to it or transfer the description of the image present when clicking into the image onto the legend as to better represent what the image is about while having the passage right next to it. Furthermore, maybe it would be beneficial to add other forms of media such as videos to compliment the passages as well, and help better engage the reader in the topic.
With regards to your section on the canonical pathway, I’ve noticed that the specific genes that are targeted by Notch have been left out and I feel that it is important to mention those genes targets explicitly there as well. That being said, they are mentioned in the proceeding section so it isn’t imperative that you do this. Maybe also try seeing if there is any literature on how the NOTCH receptors come about, such as what genes transcribe it and how the protein is processed and expressed before signalling in the pathway can occur.
I think for the most part there is very little to improve with your wiki page given the quality of it albeit a few minor corrections that I have mentioned above. It is very concise and at no times do I feel that I am reading a wall of text that is disengaging. Thus I feel that as long as such quality is maintained then your wiki page will be quite good when finished.
Group 2 – Notch Signaling Pathway
First impressions of Group 2’s page on the notch-signaling pathway are all positive. Subheadings are very well defined. They have chosen to include a brief yet informative introduction on the pathway, a simple table outlining the major scientific developments over the last 100 years, the molecular mechanisms of the pathway, its specific role in embryonic development (which they have further defined as cardiovascular and CNS), role in animal development, abnormalities relating to this pathway and a glossary. I think another positive aspect of this project, is that they have identified additional subheadings for which they are still to do research on; a particularly important one is current areas of research which not many groups have included. Furthermore, additional positive aspects of this project include the addition of images on the canonical notch signaling pathway and its role in cardiovascular development (which both appear also to be appropriately added to the website), which support the text nicely. It might also be useful to find a relevant video to include just to break up some of the text, and help make the page more interactive. It appears this group has widely researched their topic using both primary and review articles, which are all appropriately referenced using in-text citations. All of these aspects help to clearly convey the necessary information to the reader, and fulfill much of the required criteria of this project. In terms of their written information, Group 2 has included really detailed information on its role in embryonic cardiovascular development, as well as identifying some of the major research articles that have lead to these discoveries and a little bit about them (which then the reader if they are interested it can go read thanks to the inclusion of the in-text citations.) They do include a section of the roles of this pathway in animal development, which is really interesting and goes beyond the normal scope of this course.
Some negative aspects of the project include that, as part of the criteria being that the project has an “element of teaching at a peer level using the student's own innovative diagrams, tables or figures and/or using interesting examples or explanations” perhaps it would be useful to consider including a hand drawn image when researching the non-canonical pathway or transcriptional regulation of notch signaling, or even of some of the receptor/ligands involved in this signaling pathway. Furthermore, on a similar note it may be important to summarise the receptor subtypes involved in the different pathways, their role in embryonic development and abnormalities of the receptor subtype specifically relating to embryonic development in a table or dot point format. Additionally perhaps more information on its role in the CNS (or other systems during embryonic development) even if its not as detailed as cardiovascular, may help to inform the reader of all of its various roles.
In conclusion, it appears that this project is one of the strongest, it has very clear and informative subheadings separating well researched written material, supported by images sourced from the Internet. The main criticisms were just including your own innovative diagrams or explanations, videos to help make it more interactive and table or dot points summarizing the different receptor subtypes involved in each pathway. Following the completion of this, and the subheadings yet to be researched (and glossary) it appears that this project is going to be very successful in informing peers about the said pathway.
Group 2 Peer Assessment
So far this page looks great and very organised. I am really impressed by the set out of the information and the way the headings are arranged. It made it really easy for me to navigate around for particular information and not have to look for around aimlessly when I was looking for something in particular. Furthermore I think that the actual categories/sub headings used so far are very concise and effective. For example, I appreciate the brief introduction along with an overview of the molecular mechanisms involved in notch signalling before introducing its roles in embryonic development. This way I was able to have a understanding of what is really involved before understanding how it is important in embryonic development.
The references are also very neatly and correctly done and many times when I did not fully understand a concept I clicked on the citations which took me to the relevant articles and my understanding was clarified. I also really enjoyed the commentary on the specific research papers, for example cardiomyocyte specification and differentiation where you guys actually compared information from separate studies to make the information more whole and relevant.
In the abnormalities section, I think it was really awesome you guys included so many statistics and symptoms and not just a description of the abnormality.
Although everything looks really amazing a couple of improvements that I personally think could be made would make this page really useful to students.
The introduction, although very informative can be simplified a bit more to address criteria 4 and make it a bit easier to understand. This can be done through including an interesting or very simplified diagram to engage the student from the beginning. I would also generally include more diagrams and drawings that are personally drawn as the pictures used although effective, can be difficult to understand when you are learning for the first time. It would also be nice if more words are included in the glossary because there was a quite few words I did not know the meaning of. Lastly I think it would be a great addition to your page to include another subheading which outlines how the abnormalities are treated as this is something that I was intrigued to discover.
Overall I think your page is going great guys keep it going !
Project 2: Notch signalling pathway
1. The key points relating to the topic are clearly described.
There are headings for key points and the information for these key points has clearly described. This information is laid out in a clear way beginning with an introduction, historical aspect of the topic and continues to more specific information (e.g. animal models) related to the overall topic.
2.The choice of content, headings and sub-headings, diagrams, tables, graphs show a good understanding of the topic area.
The Notch singalling pathway has a very clear contents list. This demonstrates that a lot of thought and research has gone into the topic. There are two figures which are very neat and well set out. These are referenced. There is one table which described the historical aspect of this topic and this is very clear and beneficial as it summerises a lot of information in a clear manner.
3. Content correctly cited.
The content is cited correctly. If the refernces are used more than twice this has been cited in following the Wiki guidelines and the reference is not repeated in the list.
4. The wiki has an element of teaching at a peer level using the student's own innovative diagrams, tables or figures and/or using interesting examples or explanations.
This wiki does have an element of teaching: It is clearly laid out, it is easy to read and the information is set up in a correct manner with a general overview, historical aspects and then more precise information is given. There is some interesting examples given which describes abnormalities in this pathway.
5. Evidence of significant research relating to basic and applied sciences that goes beyond the formal teaching activities.
This is very much evident. There is evidence that research has been undertaken as the topic has been divided into sub topics and there is a lot of interesting clear information to educate the reader.
6.Relates the topic and content of the Wiki entry to learning aims of embryology.
Yes the topic does related to the learning aims of embryology and how Notch signalling pathway is involved in embryonic organ development through the regulation of cell-cell signalling
7. Clearly reflects on editing/feedback from group peers and articulates how the Wiki could be improved (or not) based on peer comments/feedback. Demonstrates an ability to review own work when criticised in an open edited wiki format. Reflects on what was learned from the process of editing a peer's wiki.
This is still not as evident as there is no comments or feedback observed. There are still some sections that have information missing and perhaps comment or feedback could have been given here to ensure that the students fill in this missing information or remove the subheadings all together.
8. Evaluates own performance and that of group peers to give a rounded summary of this wiki process in terms of group effort and achievement.
The way this Wiki is laid out clearly demonstrates that there has been some feedback and communication between the group. It seems that each member of the group did write a section, yet the sections do come together and do not seem out of place. However there are sections with information missing and this needs to be addressed.
9. The content of the wiki should demonstrate to the reader that your group has researched adequately on this topic and covered the key areas necessary to inform your peers in their learning.
Yes the Wiki content does demonstrate that the group has researched adqueately in this area.
10. Develops and edits the wiki entries in accordance with the above guidelines.
This has been achieved. This wiki entry does seem to be in accordance with the guidelines provided.
Z3462474 (talk) 07:15, 23 September 2016 (AEST) Hey no worries I hope you feel better soon! I won't be able to do as much during the midsem break which is why I've been doing lots this week. I'll have a look at that link thanks! Also I tried to make a Glossary but am having trouble with the coding side of it but I'll try fix it later to make it a proper glossary :)
Z5015014 (talk) 21:00, 22 September 2016 (AEST) I'm so sorry I've been terrible with putting stuff on our page!! I know I said I would get some done this week but I've been sick these past few days and still recovering so I probably won't make it to the lab tomorrow. I'm having some trouble finding an image that summarises Notch signalling that we can use (most of the good ones I've found don't allow reuse) but I'll keep looking. I'll definitely do a lot more during the midsem break. sorry again! I also found this link: http://www.omim.org/entry/190198 that looks like it has some really good references for different roles in development.
Z5015014 (talk) 14:27, 16 September 2016 (AEST) looks like a great picture so I think we can leave it. I just altered the formatting of the image a little bit, but feel free to change it back if you prefer the previous placement! also I think having the copyright info on the file page is enough. thanks for doing that, I'm still hunting out pictures as well. I've been busy this week with another group project but now that it's out of the way I should be able to do a lot more here. :)
Z3462474 (talk) 09:21, 16 September 2016 (AEST) I found one that didnt look too complicated and also found that it allowed unrestricted use so I've added it into the cardio section of our page (we can always delete it later if need be), not 100% about my formatting though and whether I should include the legend/copyright notice directly on our page? If you click the image though its all there :)
Z5015014 (talk) 23:08, 12 September 2016 (AEST) I've been looking around and found some images, but most of the time they involve a lot more detail than we need and I don't want to overcomplicate it. will keep researching this week and see if I can find some simpler diagrams. :) The images in that book look really good but yeah I'm not sure what the copyright details for that are. if it comes to it I think if we reproduce it by hand and credit the source then it's fine!
Z3462474 (talk) 13:50, 12 September 2016 (AEST) Has anyone found any good images to use for our page? I have found a couple of diagrams on cardiac development and Notch in this book chapter: http://www.sciencedirect.com.wwwproxy0.library.unsw.edu.au/science/article/pii/S0070215310920115 but am still looking to the copyright restrictions etc and thought I'd check everyone's opinion
Z3462474 (talk) 09:22, 9 September 2016 (AEST) Hey everyone, I have added some of my notes to the main page, they are still a work in progress though! I'll continue to research the roles of Notch in the development of the different systems
Z3462474 (talk) 10:04, 2 September 2016 (AEST) Just found this online textbook titled 'Notch Signaling : Methods and Protocols' http://www.springerprotocols.com.wwwproxy0.library.unsw.edu.au/BookToc/doi/10.1007/978-1-4939-1139-4
This one also looks like it might be helpful: http://www.sciencedirect.com.wwwproxy0.library.unsw.edu.au/science/bookseries/00702153/92
Notch signalling at a glance: http://jcs.biologists.org/content/joces/126/10/2135.full.pdf
Signalling pathways for neural development: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369499/pdf/WJSC-7-437.pdf
Notch's role in diabetic neuropathy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677813/pdf/nihms473246.pdf
Notch in cardio development and disease http://circres.ahajournals.org/content/118/1/e1.full
Z5015014 (talk) 14:31, 26 August 2016 (AEST) I also found a review article for Notch signalling in the common fruit fly, which could be a good idea for a subsection: PMID 12369105 General outlines of the molecular genetics of the Notch signalling pathway in Drosophila melanogaster: a review.
Z5015014 (talk) 14:44, 26 August 2016 (AEST) and here's some more reviews: PMID 22397947 Non-canonical Notch signaling: emerging role and mechanism and PMID 21828089 Notch signaling: simplicity in design, versatility in function.
Z5014803 (talk) https://www.researchgate.net/publication/264164124_Introduction_to_Notch_Signaling This seems like a good link for the history and discovery of the pathway
Z5014803 (talk) https://embryo.asu.edu/pages/notch-signaling-pathway-embryogenesis Can be used for introduction
This web page is developing very well, with comprehensive information and textual information. Relevant images and diagrams have been included and accurately referenced, which is to be commended. Student produced images, diagrams and flowcharts should also be included to reflect depth of knowledge on this topic. More images would enhance the readers’ understanding of topics like the development of the Atrioventricular Canal, heart valve and outflow tract, all of which are subheadings. Short movies and animations should also be included to assist the readers in visualising these signalling pathways and embryological developments being discussed. An interesting and potentially humorous image could also be included at the beginning of the web page to attract the reader’s attention and add interest to the page, such as an image of an ordinary notch at the top of the page.
The subheadings included in this web page are appropriate and have been well organised, ensuring consistency and cohesiveness in this project. The introduction is well written, as it covers a range of topics including an overview of the role of the Notch signalling pathway as well as an introduction to the abnormalities associated with mutations in the functional components of the pathway. The timeline could also be improved by including developments in research over the last 20 years, as well as the direction current research is moving in and where future research could be headed. An elaboration on 1914 by further explaining why this is called the “Notch signalling pathway” with the aid of an image would also be useful. More information on John S. Dexter and his research process, his team and initial findings would also add depth and interest to the web page. Another table could be included in this web page to help the readers differentiate between the four Notch genes in Mammals, including further information on each gene, their respective locations on chromosomes, functions and an image of each if possible. The location of the locus of the Notch gene on the 3C7 band of the X chromosome is included, as well as the NOTCH3 located on chromosome 19p13, showing detailed knowledge and extensive research by the group. Images, potentially student drawn, of where these locations physically are would also reflect a deeper understanding.
The ‘Roles in Embryonic Development’ section and its respective subheadings have also been well organised and structured. There are several headings in this web page that require completion before the submission date, including the ‘non-canonical pathway’ and ‘transcriptional regulation of notch signalling’ headings. More animal models can also be included, with the subheadings in this section also requiring completion. An abnormalities section has also begun well and is detailed and well referenced. It still requires completion as some of the sub-headings are still empty. Images of symptoms of these abnormalities such as the rib and spine abnormalities associated with Spondylocostal Dysostosis, and the eye conditions and facial features associated with Alagille syndrome would add depth to this section. A glossary section has also been started, but can definitely be added to to improve the understanding of the readers. Terms to be added could include proteolytic reactions, ligands and descriptions of signalling molecules such as MyoD, Mash1 and GATA2.
Referencing has been carried out well, with in-text referencing throughout the web page. The introduction was well referenced, as well as the “Roles in Embryonic development”, “Animal Models” and “Abnormalities” sections. However, no in-text referencing has been carried out for the “Overview of Molecular Mechanisms” section and the timeline. This should be resolved as soon as possible so that external links are easily accessed by the readers should they want to seek further information. Complete and proper referencing would also satisfy one of the criteria of this assessment, that the content is correctly cited and referenced.
GROUP 2 Moving the the 2nd group I can see that their topic is mainly about the Notch receptor. They seem to elucidate upon different aspects of the receptor, like it’s role in embryonic development and molecular pathways. The aspect done especially well in this group is the vastness and breadth of their information. They explore numerous aspects of the Notch receptor, including the abnormalities that can arise in development. By showing such a vastness and clarity in their research they successfully achieve criteria 1. Furthermore, Group 2 has a phenomenal amount of tables, diagrams and figures describing canonical Notch signalling and the history of the discoveries for these receptors. This qualifies criteria 2 very well as they have included all these as well as headings and sub headings in a succinct manner. Moving onto referencing, this group has done a fantastic job in that aspect as they have a separate section for references, which is clear and easy to understand, fulfilling criteria 3. Overall, I have been able to learn from this group’s project and thus I believe that they fulfil an aspect of criteria 4, in that they have an element of teaching for peers. Improvements I might suggest would be having an even larger array of different learning outlets or media types. Examples could include maybe having a video included in your group project. In terms of improvements to specific information, maybe quickly glance over the different types of receptors and the different pathways they have.
Group 2 Peer Review
Upon first look this group’s project is very well laid out, each heading and subheading fall under each other perfectly and the overall formatting is very appealing. In conjunction with this the group has made efforts to use flowcharts and diagrams which is again another positive aspect, however they should aim to also include a student made figure as is indicated in the marking criteria.
In regards to the content of the page, the Notch signaling pathway is well introduced and the history section gives a good overview of steps taken to build up to our current knowledge of the Notch system. The referencing for this page has been done in different formats, i.e there are multiple types of intext citation, in some instances a superscript number is provided with a link where as in other cases there are author names provided, in order to increase the readability and flow of the article I recommend sticking to a single format.
The group has provided a more than substantial amount of information for a draft version of their page however in some areas it is difficult to follow along due to the presence of undefined or newly introduced terms. This problem may be alleviated by adding the more technical terms to the glossary section they have created.
The page has a proper introduction stating the critical functions of Notch signalling, examples of diseases associated with Notch mutations as well as a brief description of the mechanism of Notch signalling. There is also a timeline on the page which none of the other groups have managed to do so good job!
Some headings are missing text but those with content (e.g. canonical pathway section) are covered in extensive detail. The subheadings and headings chosen for the page indicate the group’s in depth understanding of the key components of the Notch signalling pathway. Furthermore, the page contains correct referencing and citation of text and images.
The page also discusses Notch signalling in animal models as well. A recent study was included for Drosophila. What about the other two?
Overall, Group 2 has made excellent progress. Well done!
Wow! Group 2, I was very impressed with your page. The information is organized and clearly presented under relevant headings and subheadings, with the amount of content demonstrating that you have done your research. The ‘Introduction’ at the start of your page was well written – it was short but included everything necessary, such as the processes that involve the Notch signaling pathway, how it is activated and how it is a part of the process of embryology. The history of the pathway, formatted in a timeline, could not have been done any better! I found it very easy to understand because it was presented so clearly. If it is possible to add a few more points, I think that will enhance that section even more. The content is correctly citied in this page. I was very impressed with the use of in-text references, as it enables students like me to easily access the article they have used. In addition, the complete reference list at the bottom of the page showed a large number of articles, which demonstrates that this group has done significant research relating to basic and applied sciences that goes beyond the formal teaching activities. Another positive aspect of the project is how well they have explored the Notch signalling pathway’s roles in embryonic development, which they further split into the Cardiovascular section and the Central Nervous system. Under the Cardiovascular system are numerous subheadings that further delve into how different parts of the system, such as the heart valve and atrioventricular canal, are developed. This fulfils the criteria of showing the specific role in embryonic development. I would suggest that the group add more information under Central Nervous system to balance out the content (though I am aware this is an unfinished project).
Overall, it is evident that Group 2 has diligently and consistently worked on this project. They have done an amazing job so far, and the project will become even better once more things are added and everything is finalised. Great job!
Group 2 Peer Review
Well done on the presentation and content of your topic, everything is set out very clearly and you have covered quite a lot of content. The history timeline is a great addition to the page as it outlines clearly and simply the progression through time of what new information had been learnt. The use of both tables and images assists the understanding of the individual in a simple manner. The in text citations are quite useful and extensive, it allows the reader to further their own research on a particular area of the topic. The introduction was quite detailed yet simple to understand and gave a great overall understanding of what will be included in the page. The cardiovascular information on the page related to embryonic development is a major highlight. You have covered quite a significant amount of information and yet you have distributed the information into sub-headings that allow an easier understanding of the topic.
You have also included on your page animal models and studies in relation to the Notch signalling pathway. It is quite interesting to see what the role of the pathway is in each of the models. Also, the addition of the abnormalities is quite interesting to read, and you have covered several abnormalities that can occur.
One thing I must point out is maybe you should include a more detailed glossary section, as you have used a few terms that may be hard to understand for some people, or better explain them within the paragraph. You have also included some pictures on your page, however, you do not link them to your explanation very well, maybe you should explain in detail what is exactly going on in the image. For example, it seems as if your explanation and terms used for the canonical pathway does not match those of the image for that section. Also, that particular image is not of the best quality and any writing present cannot be clearly and easily read. There are also several sub-headings that are missing information, I do, however, look forward to read what you will include
You have put together quite an impressive page with lots of information that is divided clearly into many sub-headings. It was fairly simple to understand the content, only minor changes should be made to your page.
GP2 peer review
Things are worth to be learnt:
-Formatted reference part.
-Used time line about the history the notch signalling findings.
-Suitable length for each section and informative.
Things needed to be improved:
-Pictures are assists, could be attached more.
Overall group 2 had a good progress of their project, use the history of the notch signalling as part of introduction, clear content. Only needs to fill the gaps in the page and try to add more pictures to help the audience understand the topic, especially for the abnormality of this signalling.
Group 2 Peer Assessment
Great progress so far. To start, all references have been done correctly and the appropriate subheadings and abbreviations can be seen. The history section is quite comprehensive and gives an effective background. The page describes and provides a detailed overview of the actual pathway with the visual aid of a diagram. An enhanced understanding is easily acquired with the great detail being delivered with clarity and simplicity. The inclusion of the abnormalities and its role in animal development provides a holistic understanding of the Notch signalling pathway. There is very little to improve which is of significance, however my personal contribution would be the use of a glossary to explain some confusing jargon. Keep going and you guys will do very well!