Talk:2009 Lecture 7

Three-dimensional analysis of vascular development in the mouse embryo. Walls JR, Coultas L, Rossant J, Henkelman RM. PLoS One. 2008 Aug 6;3(8):e2853. PMID: 18682734 PLoS link

Table below from Wikipedia

Type	Microscopic Appearance	Diagram	Approx. % in adults See also: Blood values	Diameter (μm)	Main targets	Nucleus	Granules	Lifetime
Neutrophil	File:PBNeutrophil.jpg	File:Neutrophil.png	54–62%	10–12	bacteria fungi	multilobed	fine, faintly pink (H&E Stain)	6 hours–few days (days in spleen and other tissue)
Eosinophil	File:Eosinophil.jpg	File:Eosinophil2.png	1–6%	10–12	parasites in allergic reactions	bi-lobed	full of pink-orange (H&E Stain)	8–12 days (circulate for 4–5 hours)
Basophil	File:PBBasophil.jpg	File:Basophil.png	<1%	12–15	in allergic reactions	bi-lobed or tri-lobed	large blue	?
Lymphocyte	File:Lymphocyte2.jpg	File:Lymphocyte.png	25–33%	7–8	B cells: various pathogens T cells: CD4+ (helper): extracellular bacteria broken down into peptides presented by MHC class 2 molecule. CD8+ cytotoxic T cells: virus-infected and tumor cells. γδ T cells: Natural killer cells: virus-infected and tumor cells.	deeply staining, eccentric	NK-cells and Cytotoxic (CD8+) T-cells	weeks to years
Monocyte		File:Monocyte.png	2–8%	14–17	Monocytes migrate from the bloodstream to other tissues and differentiate into tissue resident macrophages or dendritic cells.	kidney shaped	none	hours to days
Macrophage	File:Macrophage.jpg	File:Macrophage.png		21 (human)	Phagocytosis (engulfment and digestion) of cellular debris and pathogens, and stimulation of lymphocytes and other immune cells that respond to the pathogen.			activated: days immature: months to years
Dendritic cells	File:Dendritic cell.JPG	File:Dendritic Cell ZP.svg			Main function is as an antigen-presenting cell (APC) that activates T lymphocytes.			similar to macrophages