Paper - Growth allometry of the myocardium in human embryos from stages 15 to 23

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I have decided to take early retirement in September 2020. During the many years online I have received wonderful feedback from many readers, researchers and students interested in human embryology. I especially thank my research collaborators and contributors to the site. The good news is Embryology will remain online and I will continue my association with UNSW Australia. I look forward to updating and including the many exciting new discoveries in Embryology!

Mandarim-de-Lacerda CA. Growth allometry of the myocardium in human embryos (from stages 15 to 23). (1991) Acta Anat (Basel) 141: 251-256. PMID 1755287

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This 1991 paper by Mandarim-de-Lacerda describes heart development in human embryos from the Carnegie Collection. Note only the paper abstract is shown online for educational purposes.



  • Allometry - refers to the general relationship of body size to shape.
  • Cavalieri's Principle - if, in two solids of equal altitude, the sections made by planes parallel to and at the same distance from their respective bases are always equal, then the volumes of the two solids are equal.


PubMed reference: Mandarim-de-Lacerda CA. (1991). Growth allometry of the myocardium in human embryos (from stages 15 to 23). Acta Anat (Basel) , 141, 251-6. PMID: 1755287 DOI.
Also by this author:

  • Mandarim-de-Lacerda CA. (1991). Cardiac growth in staged human embryos--stages from 15 to 23, post-somitic period. Anat Anz , 173, 60-4. PMID: 1952097
  • Mandarim-de-Lacerda CA. (1991). A multivariate analysis of cardiac growth in human embryos: endocardial cushions and ventricular myocardium. Cardiovasc. Res. , 25, 855-60. PMID: 1747879 DOI.
  • Mandarim-de-Lacerda CA & de Souza RM. (1994). The growth of the embryonic rat myocardium (Carnegie stages 13 to 23). Ital J Anat Embryol , 99, 43-55. PMID: 7755445
  • Mandarim-de-Lacerda CA. (1990). [Human cardiac development: total volumetric increase of the heart, ventricular myocardium and endocardial cushions during the embryonic period]. Arq. Bras. Cardiol. , 55, 273-7. PMID: 2090068


See also: Arráez-Aybar LA, Turrero-Nogués A & Marantos-Gamarra DG. (2008). Embryonic cardiac morphometry in Carnegie stages 15-23, from the Complutense University of Madrid Institute of Embryology Human Embryo Collection. Cells Tissues Organs (Print) , 187, 211-20. PMID: 18057862 DOI. Using human embryos from the Madrid Collection.

Modern Notes: heart

Cardiovascular Links: cardiovascular | Heart Tutorial | Lecture - Early Vascular | Lecture - Heart | Movies | 2016 Cardiac Review | heart | coronary circulation | heart valve | heart rate | Circulation | blood | blood vessel | blood vessel histology | heart histology | Lymphatic | ductus venosus | spleen | Stage 22 | cardiovascular abnormalities | OMIM | 2012 ECHO Meeting | Category:Cardiovascular
Historic Embryology - Cardiovascular 
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  Historic Papers: 1891 | 1905 Cranial and Spinal Nerves | 1914 | 1926 Precervical Sinus | 1948 stages 15-18


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Week 8, GA week 10, 54 - 56 days, CRL 23 - 28 mm, Carnegie Embryos
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Growth allometry of the myocardium in human embryos (from stages 15 to 23)

Mandarim-de-Lacerda CA.

Department of Anatomy, State University of Rio de Janeiro, Brazil.

Abstract

The relative growth of the myocardium was studied in 27 staged human embryos (Carnegie stages).

The volume of the myocardium was determined for each embryo according to Cavalieri's principle (by using point-counting planimetry to determine the area of the profiles of the myocardium). The volume of the myocardium (variable Y) was correlated to embryonic crown-rump length (variable X in millimeters) and age (in days). The bivariate allometric equation was used as Y = aXb. The scatterplot was discontinuous, presenting two trends during the postsomitic period. The first part was composed of embryos staged from stages 15 to 20, and the second part by embryos staged from stages 21 to 23.


The breakpoint between these different trends was found at the level of stage 20 (embryo of 22 mm in crown-rump length and age nearly of 52 days). From stages 15 to 20, the growth rate of the myocardium was allometrically negative. On the other hand, from stages 21 to 23 this growth rate was moderately allometrically positive.


These differences in growth of the myocardium were analyzed and, at least partially, might be due to the functional circulatory increase in the peripheral vascular bed in correlation to the cardiac hemodynamic demand required at the end of the embryonic period proper.



Cite this page: Hill, M.A. (2020, July 4) Embryology Paper - Growth allometry of the myocardium in human embryos from stages 15 to 23. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Paper_-_Growth_allometry_of_the_myocardium_in_human_embryos_from_stages_15_to_23

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