|Embryology - 10 Jul 2020 Expand to Translate|
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|A personal message from Dr Mark Hill (May 2020)|
|contributors to the site. The good news is Embryology will remain online and I will continue my association with UNSW Australia. I look forward to updating and including the many exciting new discoveries in Embryology!|
The domestic sheep (Ovis aries) has been used as a mammalian model of development with a term gestational period of 145 - 150 days.
|Animal Development Time|
|Animal Notes and Table Data Sources
Some Recent Findings
|More recent papers|
This table allows an automated computer search of the external PubMed database using the listed "Search term" text link.
|These papers originally appeared in the Some Recent Findings table, but as that list grew in length have now been shuffled down to this collapsible table.
|4||embryo enters the uterus at the morula stage|
|8||blastocyst hatches from zona pellucida|
|11-16||elongates to a filamentous form|
|14 - 16||binucleate cells begin to differentiate in the trophoblast|
See also Implantation mechanisms: insights from the sheep
A female domestic sheep remarkable in being the first mammal to be cloned from an adult somatic cell, using the process of nuclear transfer.
Cloned by Ian Wilmut, Keith Campbell and colleagues at the Roslin Institute near Edinburgh in Scotland, born on 5 July 1996 and she lived until the age of six (5 July 1996 – 14 February 2003). The cell used as the donor for the cloning of Dolly was taken from a mammary gland, and the production of a healthy clone therefore proved that a cell taken from a specific part of the body could recreate a whole individual. As Dolly was cloned from part of a mammary gland, she was named after the famously curvaceous country western singer Dolly Parton.
|Sheep follicle gene expression||
Sheep Oocyte Distribution of Telomerase reverse transcriptase
The following oocyte images are from a recent study of sheep in vitro follicle development.
|early antral||preovulatory follicle|
- TERT - Red (Cy3-conjugated secondary antibody) (telomerase reverse transcriptase, TERT)
- DNA - Green (SYBR Green 14/I)
- Sheep Oocyte TERT: preantral | early antral | early antral | preovulatory follicle | Oocyte Development | Sheep Development
Phases of fetal lung development:
- embryonic - 0 to 40 days.
- pseudoglandular - 40 to 80 days.
- canalicular - 80 to 120 days.
- saccular - 120 to term 148 days gestation.
- Links: Respiratory Development
Lymphocytes development has been characterised by an immunohistology study of T lymphocytes in the sheep fetal spleen.
|Day (days of gestation)||Event|
|43 - 44||SBU-T1- and SBU-T8-positive lymphocytes were present in low numbers.|
|45 - 50||Surface immunoglobulin (sIg) was first detected on fetal spleen cells|
|50 - 55||SBU-T4, 20.96-, 25.69-, 38.38-, or 46.66-positive lymphocytes present.|
|57||SBU-T19 lymphocytes appeared.|
- Links: Immune Development
- Sinclair KD, Corr SA, Gutierrez CG, Fisher PA, Lee JH, Rathbone AJ, Choi I, Campbell KH & Gardner DS. (2016). Healthy ageing of cloned sheep. Nat Commun , 7, 12359. PMID: 27459299 DOI.
- Arunakumari G, Shanmugasundaram N & Rao VH. (2010). Development of morulae from the oocytes of cultured sheep preantral follicles. Theriogenology , 74, 884-94. PMID: 20615540 DOI.
- Black SG, Arnaud F, Burghardt RC, Satterfield MC, Fleming JA, Long CR, Hanna C, Murphy L, Biek R, Palmarini M & Spencer TE. (2010). Viral particles of endogenous betaretroviruses are released in the sheep uterus and infect the conceptus trophectoderm in a transspecies embryo transfer model. J. Virol. , 84, 9078-85. PMID: 20610723 DOI.
- Barboni B, Russo V, Cecconi S, Curini V, Colosimo A, Garofalo ML, Capacchietti G, Di Giacinto O & Mattioli M. (2011). In vitro grown sheep preantral follicles yield oocytes with normal nuclear-epigenetic maturation. PLoS ONE , 6, e27550. PMID: 22132111 DOI.
- Spencer TE, Johnson GA, Bazer FW & Burghardt RC. (2004). Implantation mechanisms: insights from the sheep. Reproduction , 128, 657-68. PMID: 15579583 DOI.
- Wilmut I, Schnieke AE, McWhir J, Kind AJ & Campbell KH. (1997). Viable offspring derived from fetal and adult mammalian cells. Nature , 385, 810-3. PMID: 9039911 DOI.
- Bonnet A, Servin B, Mulsant P & Mandon-Pepin B. (2015). Spatio-Temporal Gene Expression Profiling during In Vivo Early Ovarian Folliculogenesis: Integrated Transcriptomic Study and Molecular Signature of Early Follicular Growth. PLoS ONE , 10, e0141482. PMID: 26540452 DOI.
- Gnanalingham MG, Mostyn A, Dandrea J, Yakubu DP, Symonds ME & Stephenson T. (2005). Ontogeny and nutritional programming of uncoupling protein-2 and glucocorticoid receptor mRNA in the ovine lung. J. Physiol. (Lond.) , 565, 159-69. PMID: 15774522 DOI.
- Maddox JF, Mackay CR & Brandon MR. (1987). Ontogeny of ovine lymphocytes. II. An immunohistological study on the development of T lymphocytes in the sheep fetal spleen. Immunology , 62, 107-12. PMID: 3308689
Gebreselassie G, Berihulay H, Jiang L & Ma Y. (2019). Review on Genomic Regions and Candidate Genes Associated with Economically Important Production and Reproduction Traits in Sheep (Ovies aries). Animals (Basel) , 10, . PMID: 31877963 DOI.
Lazzari G, Colleoni S, Lagutina I, Crotti G, Turini P, Tessaro I, Brunetti D, Duchi R & Galli C. (2010). Short-term and long-term effects of embryo culture in the surrogate sheep oviduct versus in vitro culture for different domestic species. Theriogenology , 73, 748-57. PMID: 19726075 DOI.
Guillomot M, Turbe A, Hue I & Renard JP. (2004). Staging of ovine embryos and expression of the T-box genes Brachyury and Eomesodermin around gastrulation. Reproduction , 127, 491-501. PMID: 15047940 DOI.
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Cite this page: Hill, M.A. (2020, July 10) Embryology Sheep Development. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Sheep_Development
- © Dr Mark Hill 2020, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G