File talk:Gastrointestinal tract intestine immune cartoon 01.jpg
From Embryology
Mesenteric lymph nodes at the center of immune anatomy
J Exp Med. 2006 Mar 20;203(3):497-500. Epub 2006 Mar 13.
Macpherson AJ1, Smith K.
Abstract
The surface of the intestinal mucosa is constantly assaulted by food antigens and enormous numbers of commensal microbes and their products, which are sampled by dendritic cells (DCs). Recent work shows that the mesenteric lymph nodes (MLNs) are the key site for tolerance induction to food proteins and that they also act as a firewall to prevent live commensal intestinal bacteria from penetrating the systemic immune system. Comment on Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells. [J Exp Med. 2006]
PMID 16533891
