File talk:Extravillous trophoblasts week 5.5.jpg

Human Extravillous Trophoblasts Penetrate Decidual Veins and Lymphatics before Remodeling Spiral Arteries during Early Pregnancy.

PLoS One. 2017 Jan 12;12(1):e0169849. doi: 10.1371/journal.pone.0169849. eCollection 2017.

He N1, van Iperen L1, de Jong D2, Szuhai K2, Helmerhorst FM3, van der Westerlaken LA3, Chuva de Sousa Lopes SM1,4.

Abstract

In humans, the defective invasion of the maternal endometrium by fetal extravillous trophoblasts (EVTs) can lead to insufficient perfusion of the placenta, resulting in pregnancy complications that can put both mother and baby at risk. To study the invasion of maternal endometrium between (W)5.5-12 weeks of gestation by EVTs, we combined fluorescence in situ hybridization, immunofluorescence and immunohistochemistry to determine the presence of (male) EVTs in the vasculature of the maternal decidua. We observed that interstitial mononuclear EVTs directly entered decidual veins and lymphatics from W5.5. This invasion of decidual veins and lymphatics occurred long before endovascular EVTs remodelled decidual spiral arteries. This unexpected early entrance of interstitial mononuclear EVTs in the maternal circulation does not seem to contribute to the materno-placental vascular connection directly, but rather to establish (and expand) the materno-fetal interface through an alternative vascular route.

PMID 28081266 DOI: 10.1371/journal.pone.0169849