File:Typical tbx protein structure.png

T-box protein structure

Example using Tbx3 which includes: a T-box DNA-binding domain (orange), R = repression domains (green), A = activation domain (blue) and other protein coding regions (white). The amino and carboxy termini of the protein are labelled N and C respectively. The T-box domain spans 180-200 amino acid residues and is conserved in all T-box proteins. A T-box protein is typically 50 - 78 kDa, within which the T-box domain is typically 17 - 26 kDa. This T-box is conserved in all T-box proteins and spans 180-200 amino acid residues and binds DNA in a sequence-specific manner. They bind to the DNA consensus sequence TCACACCT.

Based on understanding from: <pubmed>11689487</pubmed>

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