File:Thalidomide destabilizes CD147.jpg
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Thalidomide destabilizes CD147 to cause Teratogenicity
a) Top, representative images of zebrafish larvae that were treated with either DMSO or 400 μM thalidomide (Thal) and analyzed at 3 d post fertilization (d.p.f.); anterior to the left, dorsal view. The dashed lines demarcate the eyes.
Thalidomide (and the derivatives lenalidomide and pomalidomide) are treatments for hematologic malignancies, multiple myeloma (MM) and del(5q) myelodysplastic syndrome (MDS). Cereblon (CRBN) is a substrate receptor of the CRL4 ubiquitin ligase complex and is the primary target by which they mediate anticancer and teratogenic effects. The ubiquitin-independent physiological chaperone-like function of CRBN that promotes maturation of the CD147 and solute carrier family 16 member 1 (SLC16A1; also known as MCT1) proteins. (text modified form abstract)
CD147
(basigin, BSG) Basigin is a member of the immunoglobulin (Ig) superfamily, with a structure related to the putative primordial form of the family.
- Links: Thalidomide | OMIM - Basigin
Reference
<pubmed>27294876</pubmed>
Copyright
Reprinted by permission from Macmillan Publishers Ltd: Nature Medicine (Eichner R, Heider M, Fernández-Sáiz V, van Bebber F, Garz AK, Lemeer S, Rudelius M, Targosz BS, Jacobs L, Knorn AM, Slawska J, Platzbecker U, Germing U, Langer C, Knop S, Einsele H, Peschel C, Haass C, Keller U, Schmid B, Götze KS, Kuster B, Bassermann F. Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity), copyright (2016).
Figure 6 Nm.4128-F6.jpg resized and PMID added. Note this image will be updated when the journal is available in print.
Licensee: Mark A Hill License Date: Jun 16, 2016 License Number: 3891130012769 Publication: Nature Medicine Title: Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity Type Of Use: post on a website Total: 0.00 USD
Cite this page: Hill, M.A. (2024, April 19) Embryology Thalidomide destabilizes CD147.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Thalidomide_destabilizes_CD147.jpg
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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| current | 13:44, 17 June 2016 | | 900 × 449 (88 KB) | Z8600021 (talk | contribs) | ==Thalidomide destabilizes CD147 to cause teratogenicity== ====Copyright==== Figure 6 Nm.4128-F6.jpg resized and PMID added. Licensee: Mark A Hill License Date: Jun 16, 2016 License Number: 3891130012769 Publication: Nature Medicine Title: Imm... |
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