File:Spleen white pulp development model.jpg
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Spleen White Pulp Development Mouse Model
Proposed interactions between spleen organiser cells and LTi/B cells which leads to marginal zone remodelling and adult white pulp formation.
Late embryogenesis (E16.5), CD4+IL-7Rα+ lymphoid tissue inducer (LTi) cells can be observed between the central arteriole (CA) and presumptive MAdCAM-1+VE-Cadherin+ spleen organiser (SPo) cells.
After birth LTi continue to co-localise with SPo (MAdCAM-1+CD31+), which form a primitive marginal zone network surrounding the CD31+ central arterioles. This postnatal developmental stage coincides with B cell migration into the spleen, and both LTi and B cells contribute to lymphotoxin signalling which upregulates MAdCAM-1 expression in the marginal zone, and initiates vascular reorganisation of the Flk-1+ephrinB2+ marginal sinus (MS) network that extends through the white pulp.
Adult MAdCAM-1+CD31+ cells are localised in the marginal zone and represent mature marginal zone reticular cells (MRC).
(figure legend)
Reference
Tan JKH & Watanabe T. (2018). Determinants of postnatal spleen tissue regeneration and organogenesis. NPJ Regen Med , 3, 1. PMID: 29367882 DOI.
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Cite this page: Hill, M.A. (2024, April 19) Embryology Spleen white pulp development model.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Spleen_white_pulp_development_model.jpg
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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