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Immortal germ cells are spermatogonial stem cells (SSCs)

(A) Outline of the experimental protocol to yield single cell–derived long-lasting clones and subsequent transplantation of cells from these clones into presterilized recipient rat testes.

(B) A wild-type recipient testis transplanted with a long-lasting clone derived from single EGFP-positive germ cell. The donor SSC-derived EGFP-positive spermatogenic colonies (left) indicate the founding cell of the long-lasting clone was an SSC. An enlarged view of individual donor SSC derived colonies (right) showed multiple layers of differentiating germ cells. This testis is representative of the 26 recipient testes, all of which were colonized similarly by donor SSCs from long-lasting clones.

White boxes indicate sections that have been enlarged. Bars: (left) 500 µm; (right) 100 µm.

Original file name: Figure 2. F2.large.jpg http://jcb.rupress.org/content/187/4/513/F2.large.jpg

Reference

Wu Z, Luby-Phelps K, Bugde A, Molyneux LA, Denard B, Li WH, Süel GM, Garbers DL. Capacity for stochastic self-renewal and differentiation in mammalian spermatogonial stem cells. J Cell Biol. 2009 Nov 16;187(4):513-24. PMID:19948499 | PMC2779229 | J Cell Biol.


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