File:Protein-protein interaction.jpg

Protein-Protein interaction in fertilisation

Putative protein-protein contact residues in SPE-42 homology model.

(A) Interaction between TRAF6 (gray) and Ubc13 (red) including the SPE-42 RING domain (green) aligned for comparison. TRAF-6 was co-crystalized with Ubc13 in pdb:3HCT. Following structural alignment of SPE-42, all residues within 5Å of Ubc13 were determined and shown. (B) SPE-42 RING domain alone with putative protein-protein interacting residues on SPE-42 surface shown. Individual amino acids are labelled and numbered in accordance with the complete SPE-42 amino acid sequence.

Reference

<pubmed>21345212</pubmed>

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