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Notch signalling activity during muscle regeneration
Muscle quiescent, G0-arrested satellite cells have high Notch activity (purple line), which maintains Pax7 and inhibits Myod (indirectly: dotted line) and Myogenin (directly via Hey1) expression. Immediately after activation, satellite cells downregulate Notch activity and express Myod that is required for appropriate Cdc6 expression and S-phase entry. During the amplification phase high Notch activity is restricted to upstream, Pax7Hi cells that remain undifferentiated and self-renew to replenish the satellite cell pool. Notch activation is triggered by Dll1-bearing differentiating myoblasts. Non-muscle cells, like infiltrating inflammatory cells and fibro/adipogenic progenitors could also trigger or influence Notch activation. The expression of Dll ligands by the mature myofibres is likely, but remains to be demonstrated.
- Links: Notch | Muscle Development
Reference
<pubmed>24472470</pubmed>| BMC Dev Biol.
Copyright
© 2014 Mourikis and Tajbakhsh; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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current | 13:56, 23 March 2014 | 1,000 × 588 (102 KB) | Z8600021 (talk | contribs) | Notch signalling activity during muscle regeneration. Upper panel: In wild type muscle, quiescent, G0-arrested satellite cells have high Notch activity (purple line), which maintains Pax7 and inhibits Myod (indirectly: dotted line) and Myogenin (direct... |
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