File:Neutrophil function model 02.jpg

Neutrophil Novel Functional Model

Novel interactions of neutrophils with other immune cells.

• A - Neutrophils (PMN) accumulate in the splenic marginal zone upon microbial challenge and facilitate the antibody production and maturation of marginal zone B cells (MZB) in response to T cell–independent (TI) antigens.
• B - Neutrophils participate in a vicious cycle during autoimmune disease (e.g., SLE) pathogenesis by releasing NETs that trigger pDCs to release IFN-α, which then promotes antibody production by B cells (B).
• C - Neutrophils may directly present antigens to T cells (T) and they also activate DCs and deliver antigens to them.
• D - Neutrophils and DCs jointly activate NK cells (NK).

Immune Links: Neutrophil classical model | Neutrophil novel model | image - neutrophil histology | Immune System Development

Reference

<pubmed>23825232</pubmed>| J Exp Med.

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Figure 2. http://jem.rupress.org/content/210/7/1283/F2.large.jpg PMID label added.CategoryCartoon