File:Neural tube dorsoventral patterning SHH BMP.jpg
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Neural tube Dorsoventral Patterning by SHH BMP
Neural tube cross section dorsoventral domains are established by opposing concentration gradients of Sonic Hedgehog (Shh) and Bone Morphogenic Protein (BMP).
- left - These regulate progenitor gene expression. The progenitor genes cross-repress each other to establish domain boundaries.
- right - Each domain will give rise to a specific cell type that expresses various post-mitotic differentiation genes.
- Links: Spinal Cord Development | SHH | BMP
Referfence
Zannino DA & Sagerström CG. (2015). An emerging role for prdm family genes in dorsoventral patterning of the vertebrate nervous system. Neural Dev , 10, 24. PMID: 26499851 DOI.
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Fig. 1 Original image resized and labeled with PMID.
Cite this page: Hill, M.A. (2024, April 19) Embryology Neural tube dorsoventral patterning SHH BMP.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Neural_tube_dorsoventral_patterning_SHH_BMP.jpg
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 15:25, 9 February 2016 | | 1,099 × 891 (148 KB) | Z8600021 (talk | contribs) | |
| 15:25, 9 February 2016 |  | 1,965 × 1,313 (283 KB) | Z8600021 (talk | contribs) | Schematic diagram of a neural tube cross section. Dorsoventral domains are established by opposing concentration gradients of Shh and BMP (center), which regulate progenitor gene expression (left). The progenitor genes cross-repress each other to estab... |
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