File:Mouse sex determination genes 01.jpg

Sex Determination in Mice

E10.5 - bipotential gonads arise from the genital ridges.

E10.5 - somatic cells of XY genital ridges, Sry expression (dark blue line at lower part of figure) starts

E11.5 - Sry expression reaches a peak

E12.5 - Sry wanes then a few hours later, Sox9 expression (light blue line at the lower part of the figure) is upregulated to induce di erentiation of Sertoli cells.

E11.5 to E12.5 - Sox9 expression peaks and continues to be expressed postnatally and is supported by several positive-feedback loops (including fibroblast growth factor 9 (FGF9), prostaglandin D2 (PGD2) and SOX9 itself ), and SOX9 subsequently activates many male-specific genes, including the gene encoding anti-Müllerian hormone (Amh).

E12.5 - morphological di erences between testis and ovary are evident. In the absence of SRY, genes such as Wnt4, Rspo1 and Foxl2 are expressed in a female-specific manner and induce ovarian development, as characterized by the expression of follistatin and many other ovary-specific genes. FOXL2, forkhead box L2; SOX9, SRY box containing gene 9; SRY, sex-determining region on the chromosome Y.

Links: ovary | testis | mouse | Wnt

Reference

de Lau WB, Snel B & Clevers HC. (2012). The R-spondin protein family. Genome Biol. , 13, 242. PMID: 22439850 DOI.

Kashimada K & Koopman P. (2010). Sry: the master switch in mammalian sex determination. Development , 137, 3921-30. PMID: 21062860 DOI.

Copyright

© BioMed Central Ltd. 2012

Text modified from Figure legend.

Cite this page: Hill, M.A. (2024, April 25) Embryology Mouse sex determination genes 01.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Mouse_sex_determination_genes_01.jpg

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