File:Mouse embryo cortex radial expansion.jpg

RA Is Not Required for Radial Expansion of the Embryonic Cortex

Cortical expansion appears normal in embryos lacking RA synthesis in meninges

(A–B) Raldh2−/− embryos at E14.5 exhibit relatively normal craniofacial development while they display stunted forelimbs (f).

(C–D) Tuj1 labeling of postmitotic neuronal layer in E14.5 wild-type (WT) and Raldh2−/− (KO) forebrains. Arrows (same length) demonstrate that Raldh2−/− mutant does not exhibit a change in medial-lateral width of the dorsal ventricular zone (vz; labeled with DAPI) compared to wild-type.

(E–J) Double-labeling of E14.5 forebrains with Tuj1 (green) and Ki67 (red; proliferative progenitor layer). Arrows (same length) demonstrate that the Raldh2−/− forebrain exhibits no change in radial expansion of the cortex (cx) or ventricular zone (vz) compared to wild-type. Similar results were observed for all mutants analyzed (n = 3).

Links: Retinoic acid

Reference

<pubmed>21532733</pubmed>| PLoS Biology

Copyright

© 2011 Chatzi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Citation: Chatzi C, Brade T, Duester G (2011) Retinoic Acid Functions as a Key GABAergic Differentiation Signal in the Basal Ganglia. PLoS Biol 9(4): e1000609. doi:10.1371/journal.pbio.1000609

Original file name: Figure 7. Journal.pbio.1000609.g007.jpg

doi:10.1371/journal.pbio.1000609.g007