File:Mouse cleaved intracellular portion of Notch E8.5.jpg

Mouse Cleaved intracellular portion of Notch E8.5

Immunostaining prepared using the anti-NICD antibody on cross-sections of E8.5 unsegmented presomitic mesoderm (PSM).

Cleaved intracellular portion of Notch (NICD)

• the active fragment of Notch
• generated when Notch receptor after its interaction with the ligand is processed by the γ-secretase complex

Original file name: Figure 5. http://www.plosgenetics.org/article/slideshow.action?uri=info:doi/10.1371/journal.pgen.1000662&imageURI=info:doi/10.1371/journal.pgen.1000662.g005

(WT panel removed from original figure and cropped to better fit screen)

Reference

<pubmed>19779553</pubmed>| PMC2739441 | PLoS Genet.

Citation: Ferjentsik Z, Hayashi S, Dale JK, Bessho Y, Herreman A, et al. (2009) Notch Is a Critical Component of the Mouse Somitogenesis Oscillator and Is Essential for the Formation of the Somites. PLoS Genet 5(9): e1000662. doi:10.1371/journal.pgen.1000662

Received: February 20, 2009; Accepted: August 26, 2009; Published: September 25, 2009

Copyright: © 2009 Ferjentsik et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.