File:Mouse - forebrain Robo3 expression.jpg

Mouse - forebrain Robo3 Expression

Expression of Robo3 protein at rostral (A, E, I), middle (B, F, J), and caudal (C, G, K) levels of the embryonic mouse forebrain during preplate stages of development (E11.5–13.5).

(D, H) Higher magnification images taken through middle levels of the cortex at E11.5 (D) and E12.5 (H).

Scale bar in (C), (G), and (K) is 200 μm and applies to panels of equivalent ages

Scale bar in H is 200 μm and also applies to (D) (Cx, cortex; CH cortical hem).

• roundabout, axon guidance receptor, homolog 3
• members of the Roundabout (Robo) receptor family, Robo1 and Robo2, play significant roles in the formation of axonal tracks in the developing forebrain and in the migration and morphological differentiation of cortical interneurons
• receptor is strongly expressed in the preplate layer and cortical hem of the early cortex where it colocalizes with markers of Cajal-Retzius cells and interneurons
• 19 different mutations in the ROBO3 gene have been identified in people with horizontal gaze palsy with progressive scoliosis (HGPPS).

Links: OMIM - ROBO3 | Mouse Development | Neural System Development

Original file name: Figure 1. F1-2.large.jpg http://cercor.oxfordjournals.org/content/19/suppl_1/i22/F1.large.jpg

Reference

<pubmed>19366869</pubmed>| Cereb Cortex.

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