File:Mouse- intervertebral disc development 02.jpg

Mouse Intervertebral Disc Development

Intervertebral disc (IVD) expression of transcription factor Nuclear factor of activated T-cells, cytoplasmic 1 (Nfatc1) identified by microarray and confirmed by in situ hybridization

(A) A digoxigenin labelled probe to Nfatc1 was hybridized to sections from E12.5 day embryos. Hybridization was visualized as purple staining. Nfatc1 was clearly expressed in the IVD (D, arrow) at this stage.

• The NFAT family of transcription factors regulates cytokine gene expression by binding to the promoter/enhancer regions of antigen-responsive genes, usually in cooperation with heterologous DNA-binding partners.
• The activation of NFAT proteins is controlled by calcineurin, the calmodulin-dependent phosphatase.

Links: Complete original figure | OMIM - NFATC1

Original file name: Figure 2. 1471-213X-10-29-2.jpg http://www.biomedcentral.com/1471-213X/10/29/figure/F2 (A cropped, resized and contrast adjusted from original image)

Reference

<pubmed>20214815</pubmed>| PMC2848151 | BMC Dev Biol.

© 2010 Sohn et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.