File:Mouse- intervertebral disc development.jpg

Mouse Intervertebral Disc Development

Intervertebral disc (IVD) expression of transcription factor Nuclear factor of activated T-cells, cytoplasmic 1 (Nfatc1) identified by microarray and confirmed by in situ hybridization

(A) A digoxigenin labelled probe to Nfatc1 was hybridized to sections from E12.5 day embryos. Hybridization was visualized as purple staining. Nfatc1 was clearly expressed in the IVD (D, arrow) at this stage.

(B) A digoxigenin labelled probe to Ebfa1 was hybridized to sections from E12.5 day embryos. Expression was not detected in the IVD (D) but light purple staining was seen in the vertebral body (V). Staining was also seen in the neural tube (NT) and adjacent blood vessels.

• The NFAT family of transcription factors regulates cytokine gene expression by binding to the promoter/enhancer regions of antigen-responsive genes, usually in cooperation with heterologous DNA-binding partners.
• The activation of NFAT proteins is controlled by calcineurin, the calmodulin-dependent phosphatase.

Links: Part A of figure | OMIM - NFATC1

Original file name: Figure 2. 1471-213X-10-29-2.jpg http://www.biomedcentral.com/1471-213X/10/29/figure/F2

Reference

<pubmed>20214815</pubmed>| PMC2848151 | BMC Dev Biol.

© 2010 Sohn et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.