File:Mouse- chuzhoi mutant.jpg

Mouse Chuzhoi Mutants exhibit multiple developmental abnormalities

Chuzhoi is a novel mouse mutant that arose from an N-ethyl-N-nitrosourea (ENU)-induced mutant screen. This new mouse mutant provides evidence that disruption of the planar cell polarity signalling pathway causes defects in neural tube, heart and lung development.

(A-D) E17.5 wild-type (A) and chuzhoi embryos (B-D) in lateral (A-C) and dorsal view (D). Chuzhoi embryos demonstrate the severe neural tube defect of craniorachischisis, where the neural tube is open from the midbrain/hindbrain boundary throughout the hindbrain and spinal cord, and the neural tissue is splayed on either side of the dorsal midline (D). Some chuzhoi mutants demonstrate failure to form closed eyelids (C) and a defect in ventral body wall development (likely omphalocele) with protrusion of the liver and guts (C).

Original file name: Figure 1. (original full image has been cropped and size altered)

Reference

<pubmed>20704721</pubmed>| BMC Dev Biol.

© 2010 Paudyal et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.