File:Model for tumorigenic effect of CD147 action on CD98.jpg

Model for Tumorigenic Effect of CD147 action on CD98

Model for how CD147 (basigin facilitates the membrane distribution of CD98 to promote HCC cell spreading and tumorigenicity. Basigin (CD147, BSG) is a member of the immunoglobulin (Ig) superfamily, with a structure related to the putative primordial form of the family.

General model for basigin promotes the membrane localization of CD98 and activation of β1-integrin. Basigin could facilitate the membrane localization of newly synthesized CD98 in the ER (blue arrow). Prototypical CIE cargo proteins enter cells through Arf6-positive endocytic vesicles that either fuse with or mature into Rab5a-positive early endosomes (sorting endosomes), where internalized proteins converge and are sorted for recycling (green arrow) or degradation (red arrow). Basigin and CD98 are internalized by a pathway associated with flotillin-1 and the small G protein Arf6. Thereafter, basigin and CD98 could recycle back to the membrane through the fast recycling pathway (green arrow A) mediated by hook1, Rab22a, microtubules and their own cytoplasmic sequences. Other internalized proteins, including integrins, could recycle through the slow recycling pathway (green arrow B). By promoting the membrane redistribution or translocation of CD98, basigin activates β1 integrins and plays a critical role in liver cancer progression

Links: Thalidomide | OMIM - Basigin

Reference

Wu B, Wang Y, Yang XM, Xu BQ, Feng F, Wang B, Liang Q, Li Y, Zhou Y, Jiang JL & Chen ZN. (2015). Basigin-mediated redistribution of CD98 promotes cell spreading and tumorigenicity in hepatocellular carcinoma. J. Exp. Clin. Cancer Res. , 34, 110. PMID: 26437640 DOI.

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Cite this page: Hill, M.A. (2024, April 25) Embryology Model for tumorigenic effect of CD147 action on CD98.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Model_for_tumorigenic_effect_of_CD147_action_on_CD98.jpg

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