File:Model for granulocytic nuclear lobulation.jpg
Original file (600 × 930 pixels, file size: 85 KB, MIME type: image/jpeg)
Model for granulocytic nuclear lobulation
A. Postulated changes in nuclear envelope flexibility arising from changes in nuclear envelope composition
HL-60 cell states: undifferentiated; granulocyte, RA treated; monocyte, TPA treated. Abbreviations: inm, inner nuclear membrane; LMNB2, lamin B2; LMNA/C, lamins A/C; LMNB1, lamin B1; HP1, heterochromatin protein 1; LBR, lamin B receptor. Due to a paucity of lamins A/C and B1, the nuclear envelope is believed to be more flexible in the undifferentiated and granulocytic cell states.
B. Balance of forces postulated to be affecting granulocytic nuclear shape
Microtubules (green) and affiliated dynein motors (red circles) are assumed to produce nuclear envelope invaginations (bent arrows). Actin with affiliated spectrin-like proteins and vimentin are assumed to be pulling outwards on the nuclear envelope (thin arrows). Current evidence does not favor a major contribution by actin; any significant contribution by vimentin is presently unknown. The large straight arrows indicate continued influx of nuclear envelope components from the endoplasmic reticulum, allowing sustained membrane growth.
Abbreviations: MTs, microtubules; IFs, intermediate filaments; ER, endoplasmic reticulum; Eu, euchromatin; H, heterochromatin. The nuclear compartment is colored blue; the cytoplasm, pink.
Original file name: 1471-2121-5-30-16.jpg http://www.biomedcentral.com/1471-2121/5/30/figure/F16
Reference
<pubmed>15317658</pubmed>| PMC516025 | BMC Cell Biol.
Olins and Olins BMC Cell Biology 2004 5:30 doi:10.1186/1471-2121-5-30
© 2004 Olins and Olins; licensee BioMed Central Ltd.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
File history
Click on a date/time to view the file as it appeared at that time.
Date/Time | Thumbnail | Dimensions | User | Comment | |
---|---|---|---|---|---|
current | 10:33, 28 March 2011 | 600 × 930 (85 KB) | S8600021 (talk | contribs) | ==Model for granulocytic nuclear lobulation== ===A. Postulated changes in nuclear envelope flexibility arising from changes in nuclear envelope composition=== HL-60 cell states: undifferentiated; granulocyte, RA treated; monocyte, TPA treated. Abbreviat |
You cannot overwrite this file.
File usage
There are no pages that use this file.