File:Model Sox9 lung development 01.jpg
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Model Sox9 Lung Development
Mesenchymal Sox9-expressing cells in the development of the tracheal cartilage rings, which in turn induce proper tracheal epithelium differentiation and lymphatic system development.
Sox9 acts downstream of Tbx4/5.
Sox9 feeds back negatively on Tbx4 and Tbx5 in the tracheal mesenchyme. Cartilage ring formation requires functional Sox9 expression in the tracheal mesenchyme. Lack of cartilage rings induce altered tracheal epithelium differentiation (increased Clara cells, and decreased basal and goblet cells) and defective development of tracheal vasculature structures.
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- Links: Respiratory System Development | Tbx | Sox
Reference
<pubmed>24274029</pubmed>| BMC Biol.
Copyright
© Turcatel et al.; licensee BioMed Central Ltd. 2013 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Figure 10 12915_2013_Article_737_Fig10_HTML.jpg PMID added.
Cite this page: Hill, M.A. (2024, April 23) Embryology Model Sox9 lung development 01.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Model_Sox9_lung_development_01.jpg
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 11:21, 6 March 2016 | | 600 × 576 (43 KB) | Z8600021 (talk | contribs) | ==Model Sox9 Lung Development== Lung mesenchymal expression of Sox9 plays a critical role in tracheal development BMC Biol. 2013 Nov 25;11:117. doi: 10.1186/1741-7007-11-117. Turcatel G, Rubin N, Menke DB, Martin G, Shi W, Warburton D1. Abstract BA... |
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