File:Model - TGF regulation of SHH.jpg
Model_-_TGF_regulation_of_SHH.jpg (600 × 372 pixels, file size: 45 KB, MIME type: image/jpeg)
Schematic diagram showing activation of TGF-β receptor by TGF-β1which leads to the up-regulation of Shh expression
The secreted Shh protein then activates Hh signaling pathway by inhibition of Patched (smoothened suppressor), which will repress smoothened, resulting in the activation of GLI1 and its translocation to the nucleus. GLI1 as a Hh transcription factor then could activate Hh target genes, which leads to the acquisition of EMT phenotype, and contributing to increased invasion, metastasis and drug resistance.
- "Our results show for the first time the transcriptional up-regulation of Shh by TGF-β1, which is mechanistically associated with TGF-β1 induced EMT phenotype and aggressive behavior of NSCLC cells. Thus the inhibitors of Shh signaling could be useful for the reversal of EMT phenotype, which would inhibit the metastatic potential of NSCLC cells and also make these tumors more sensitive to conventional therapeutics."
Original file name: Figure 9. Journal.pone.0016068.g009.png doi:10.1371/journal.pone.0016068.g009
Reference
Online Editor - This original article shown below has been retracted.
Citation: Maitah MY, Ali S, Ahmad A, Gadgeel S, Sarkar FH (2011) Up-Regulation of Sonic Hedgehog Contributes to TGF-β1-Induced Epithelial to Mesenchymal Transition in NSCLC Cells. PLoS ONE 6(1): e16068. doi:10.1371/journal.pone.0016068
Editor: Irina Agoulnik, Florida International University, United States of America
Received: September 14, 2010; Accepted: December 5, 2010; Published: January 13, 2011
Copyright
© 2011 Maitah et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Cite this page: Hill, M.A. (2024, April 20) Embryology Model - TGF regulation of SHH.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Model_-_TGF_regulation_of_SHH.jpg
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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| current | 11:04, 17 February 2011 | | 600 × 372 (45 KB) | S8600021 (talk | contribs) | ==Schematic diagram showing activation of TGF-β receptor by TGF-β1which leads to the up-regulation of Shh expression== The secreted Shh protein then activates Hh signaling pathway by inhibition of Patched (smoothened suppressor), which will repress smo |
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