File:Meiosis spindle movement model.jpg

Model of Meiosis Biphasic Spindle Movement and Symmetry Breaking

• A - two actin nucleators Fmn2- and Arp2/3-regulated actin-based forces drive the first and second phase of chromosome migration, respectively.
• B - A conceptual model of how symmetry breaking occurs in MI oocytes.

Fmn2 - formin 2, formin homology (FH) domain proteins have a role in cytoskeletal organization and/or establishment of cell polarity. OMIM 606373

Arp2/3 - involved in the control of actin polymerization in cells, the human complex consists of 7 subunits. OMIM 604223

Meiosis Links: Oocyte Meiosis Movie | 0 min | 270 min | 280 min | 320 min | 840 min | Meiosis spindle movement model | oocyte | meiosis | mouse | Movies

Reference

<pubmed>23439682</pubmed>| PMC3587830 | J Cell Biol.

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Fig 5 JCB_201211068_Fig5.jpg altered in size and labeling.