File:Mammary gland luminal cell model.jpg
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Model for luminal cell hierarchy during mammary gland development
(A) Lineage tracing from embryos reveals that Notch1-expressing (N1pos) multipotent stem cells exist only during embryonic mammary development, when they co-express myoepithelial cytokeratin (K5) and luminal cytokeratin (K8). These multipotent stem cells can generate all mammary lineages (labeled in green postnatally).
(B) After birth, luminal stem cells resolve in two distinct luminal progenitors: ERαpos and ERαneg cells, which maintain exclusively their own lineage throughout adulthood. Unipotent progenitors lacking ERα expression (ERαneg) marked by Notch1 are responsible for generating milk-producing alveoli at pregnancy and define self-renewing luminal cells able to survive mammary gland involution.
Reference
<pubmed>25688859</pubmed>| PLoS Biol.
Copyright
© 2015 Rodilla et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Fig 8. doi:10.1371/journal.pbio.1002069.g008
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
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| current | 21:14, 14 March 2015 | | 1,200 × 1,680 (170 KB) | Z8600021 (talk | contribs) | ==Model for luminal cell hierarchy during mammary gland development== (A) Lineage tracing from embryos reveals that Notch1-expressing (N1pos) multipotent stem cells exist only during embryonic mammary development, when they co-express myoepithelial cy... |
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