File:Lymphatic vessel development.jpg
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Lymphatic Vessel Development
(a) In response to unknown factors, lymphatic differentiation is initiated by the polarized expression of Sox18 (yellow nuclei) in venous endothelium.
(b) Subsequently, Sox18 causes Prox1 expression (brown nuclei) leading to the exodus of lymphatic progenitors (yellow cells) from the cardinal veins and the formation of primary lymph sacs at distant sites.
(c) Sox18 expression subsides, but Prox1 expression is maintained in lymphatic endothelium, and lymphatics form by sprouting from the primitive lymph sacs.
(d) Genetic ablation of Prox1 from lymphatic endothelium results in dedifferentiation. Lymphatic-specific proteins are lost, whereas blood-vessel-specific proteins are re-expressed (magenta). Blood enters the lymphatics via aberrant connections, which could be caused by fusion of adjacent vessels (white arrow) or sprouting angiogenesis (grey arrow).
- Links: Developmental Signals - Sox | OMIM - Sox18 | OMIM - Prox1
Reference
Kiefer F & Adams RH. (2008). Lymphatic endothelial differentiation: start out with Sox--carry on with Prox. Genome Biol. , 9, 243. PMID: 19138383 DOI.
Copyright
Authors of Research Articles, Methodologies and Software articles published in Genome Biology are the copyright holders of their articles and have granted to any third party, in advance and in perpetuity, the right to use, reproduce or disseminate the article, according to the BioMed Central copyright and license agreement.
Gb-2008-9-12-243-1.jpg
Cite this page: Hill, M.A. (2024, April 19) Embryology Lymphatic vessel development.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Lymphatic_vessel_development.jpg
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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