File:Lens-neural crest signaling 01.jpg

Wnt mediates lens repression by neural crest cells and Transforming growth factor-β

• Transforming growth factor β (TGF-β)
• Neural crest cell (NCC)

Proposed embryological model summarizing how NCCs organize the eye:

1. NCCs (blue) secrete TGF-βs, which signal to the non-lens ectoderm and dorsal optic vesicle.
2. As a consequence, Wnt2b (red) is induced, and together they repress lens formation in the non-lens ectoderm.
3. This leads to the alignment of Pax6 expression in the future lens and neural retina (grey).

Links: Lens Development | Lens repression by neural crest cells | Proposed model how NCCs organize the eye | molecular model to explain TGF-β- and Wnt-mediated lens restriction

Original image name: Figure 3 http://www.nature.com/ncomms/journal/v2/n4/fig_tab/ncomms1269_F3.html (panel S cropped from complete figure)

Lens-neural crest signaling 01.jpg

Reference

Grocott T, Johnson S, Bailey AP, Streit A. Neural crest cells organize the eye via TGF-β and canonical Wnt signalling. Nat Commun. 2011 Apr;2:265. PMID21468017 | Nat Commun.

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